公开(公告)号：EP1229134A3

公开(公告)日：2004-01-28

申请号：EP02250681.0

申请日：2002-01-31

申请人： Nucleonics, Inc ,  Message Pharmaceuticals, Inc.

发明人： Giordano, Tony ,  Pachuk, Catherine ,  Satishchandran, Chandrasekhar

IPC分类号： C12Q1/68 ,  C12N15/10 ,  G01N33/50

CPC分类号： C12N15/1086 ,  C12N15/1096 ,  C12Q1/6897

摘要： Described herein are methods for identifying nucleic acid sequences that modulate the function of a cell, the expression of a gene in a cell, or the biological activity of a target polypeptide in a cell. The methods involve the use of double stranded RNA expression libraries, double stranded RNA molecules, and post-transcriptional gene silencing techniques.

公开(公告)号：EP1229134A2

公开(公告)日：2002-08-07

申请号：EP02250681.0

申请日：2002-01-31

申请人： Nucleonics, Inc ,  Message Pharmaceuticals, Inc.

发明人： Giordano, Tony ,  Pachuk, Catherine ,  Satishchandran, Chandrasekhar

IPC分类号： C12Q1/68 ,  C12N15/10 ,  G01N33/50

CPC分类号： C12N15/1086 ,  C12N15/1096 ,  C12Q1/6897

摘要： Described herein are methods for identifying nucleic acid sequences that modulate the function of a cell, the expression of a gene in a cell, or the biological activity of a target polypeptide in a cell. The methods involve the use of double stranded RNA expression libraries, double stranded RNA molecules, and post-transcriptional gene silencing techniques.

摘要翻译： 用于鉴定核酸序列描述于一些方法做了调制单元的功能，一个基因在细胞中的表达，或在细胞中的靶多肽的生物活性。 该方法涉及使用双链RNA表达文库，双链RNA分子，和转录后基因沉默技术。