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1.发明公开Use of post-transcriptional gene silencing for identifying nucleic acid sequences that modulate the function of a cell 审中-公开识别核酸序列影响使用转录后基因沉默的其中的细胞的功能
公开(公告)号：EP1229134A3
公开(公告)日：2004-01-28
申请号：EP02250681.0
申请日：2002-01-31
CPC分类号： C12N15/1086 , C12N15/1096 , C12Q1/6897
摘要： Described herein are methods for identifying nucleic acid sequences that modulate the function of a cell, the expression of a gene in a cell, or the biological activity of a target polypeptide in a cell. The methods involve the use of double stranded RNA expression libraries, double stranded RNA molecules, and post-transcriptional gene silencing techniques.
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2.发明公开Functional genomic screen for post-transcriptional 5' and 3' regulatory elements 审中-公开Funktionalle genomische Selektionfürpost-transkriptionale 5'und 3'Regulationselemente
公开(公告)号：EP1176196A1
公开(公告)日：2002-01-30
申请号：EP00115854.2
申请日：2000-07-24
发明人： Giordano, Tony , Powers, Gordon D. , Eder, Paul S. , Burnett, Bonnie-Ann , Temeles, Gretchen, L.
CPC分类号： C12N15/1096 , C12N15/67
摘要： The invention features cDNA libraries consisting essentially of cDNA sequences that correspond to different mRNA untranslated region (UTR) sequences separate from adjacent mRNA coding sequences. The invention also features methods for generating these libraries and for identifying a regulatory UTR sequence.
摘要翻译： 本发明的特征在于cDNA文库基本上由对应于与相邻mRNA编码序列分开的不同mRNA非翻译区（UTR）序列的cDNA序列组成。 本发明还具有用于产生这些文库和鉴定调节性UTR序列的方法。
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3.发明公开METHODS FOR IDENTIFYING COMPOUNDS THAT AFFECT RNA/RNA BINDING PROTEIN INTERACTIONS 审中-公开一种用于识别化合物，其RNA / RNA结合蛋白相互作用的影响
公开(公告)号：EP1235840A4
公开(公告)日：2004-12-22
申请号：EP00977133
申请日：2000-11-09
发明人： GIORDANO ANTHONY , XAVIER ASISH K
CPC分类号： C12Q1/6876 , C12Q2600/136 , C12Q2600/158 , Y10T436/143333
摘要： Disclosed herein are nucleic acid sequences and their optimized subfragments which are located in the mRNA untranslated regions of therapeutically-relevant genes. These sequences specifically bind RNA binding proteins (RBPs) and/or regulate the mRNA functionality. Also disclosed are methods of optimizing a subfragment of a parent nucleic acid sequence such that the RBP binding activity or mRNA functionality of the parent nucleic acid sequence is preserved in the optimized subfragment.
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4.发明公开Use of post-transcriptional gene silencing for identifying nucleic acid sequences that modulate the function of a cell 审中-公开识别核酸序列影响使用转录后基因沉默的其中的细胞的功能
公开(公告)号：EP1229134A2
公开(公告)日：2002-08-07
申请号：EP02250681.0
申请日：2002-01-31
CPC分类号： C12N15/1086 , C12N15/1096 , C12Q1/6897
摘要： Described herein are methods for identifying nucleic acid sequences that modulate the function of a cell, the expression of a gene in a cell, or the biological activity of a target polypeptide in a cell. The methods involve the use of double stranded RNA expression libraries, double stranded RNA molecules, and post-transcriptional gene silencing techniques.
摘要翻译： 用于鉴定核酸序列描述于一些方法做了调制单元的功能，一个基因在细胞中的表达，或在细胞中的靶多肽的生物活性。 该方法涉及使用双链RNA表达文库，双链RNA分子，和转录后基因沉默技术。
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5.发明授权METHOD FOR IDENTIFYING COMPOUNDS AFFECTING RNA/RNA BINDING PROTEIN INTERACTIONS 有权对于RNA相互作用的化合物的检测和蛋白质的方法，结合RNA LEG河流
公开(公告)号：EP1117841B1
公开(公告)日：2005-03-09
申请号：EP99970130.3
申请日：1999-09-16
CPC分类号： C12Q1/6811 , C12Q2522/101
摘要： Disclosed are nucleic acid sequences which, when present in an RNA molecule, bind to RNA binding proteins. These nucleic acid sequences are present in untranslated regions of certain mRNA. They can be used in assays to identify compounds that affect the interaction of RNA containing the nucleic acid sequence, such as the source mRNA, and RNA binding proteins. The disclosed nucleic acid sequences can also be used to identify RNA binding proteins that can interact with the sequences. An assay for identifying compounds that affect interaction of RNA containing one of the disclosed nucleic acid sequences and RNA binding proteins is also disclosed. The assay involves detecting interactions between RNA binding proteins and an RNA molecule containing one of the disclosed nucleic acid sequences in the presence of a test compound and in the absence of the test compound. A difference in the detected interaction in the presence and absence of the test compound indicates that the compound affects the interaction. The identified compounds can be used to affect the interaction of RNA binding proteins with mRNA containing the nucleic acid sequences or related sequences.
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6.发明公开INHIBITORS OF RNASE P PROTEINS AS ANTIBACTERIAL COMPOUNDS 审中-公开HEMMER VON RNASE-P-PROTEINEN ALS ANTIBAKTERIELLE VERBINDUNGEN
公开(公告)号：EP1435932A2
公开(公告)日：2004-07-14
申请号：EP02773523.2
申请日：2002-09-23
IPC分类号： A61K31/16 , A61K31/34 , A61K31/425 , C07C243/20 , C07C233/05 , C07D307/78 , C07D277/62
CPC分类号： C07C257/18 , A61K31/428 , A61K31/4709 , C07C279/18 , C07C281/18 , C07C2601/14
摘要： The present invention features compounds useful for inhibiting Rnase P activity. These compounds can be used as therapeutics for treating or preventing a variety of bacterial infections. The compounds belong to several classes including mono- and bis-guanylhydrazones, guanylhydrazone mimetics, and benzothiazolium compounds. Exemplary compounds are compounds of formula (I) Y-(NR')k-U1-(NR'')l-A-(NR1)m-U2-(NR2)n-Z with substituents as described herein.
摘要翻译： 本发明的特征在于可用于抑制RNase P活性的化合物。 这些化合物可用作治疗或预防各种细菌感染的治疗剂。 这些化合物属于几类，包括单脒腙和双脒腙，脒腙模拟物和苯并噻唑鎓化合物。 示例性化合物是配方的化合物
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7.发明公开METHODS FOR IDENTIFYING COMPOUNDS THAT AFFECT RNA/RNA BINDING PROTEIN INTERACTIONS 审中-公开一种用于识别化合物，其RNA / RNA结合蛋白相互作用的影响
公开(公告)号：EP1235840A1
公开(公告)日：2002-09-04
申请号：EP00977133.8
申请日：2000-11-09
CPC分类号： C12Q1/6876 , C12Q2600/136 , C12Q2600/158 , Y10T436/143333
摘要： Disclosed herein are nucleic acid sequences and their optimized subfragments which are located in the mRNA untranslated regions of therapeutically-relevant genes. These sequences specifically bind RNA binding proteins (RBPs) and/or regulate the mRNA functionality. Also disclosed are methods of optimizing a subfragment of a parent nucleic acid sequence such that the RBP binding activity or mRNA functionality of the parent nucleic acid sequence is preserved in the optimized subfragment.
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公开(公告)号：EP1435932A4
公开(公告)日：2006-12-06
申请号：EP02773523
申请日：2002-09-23
发明人： GIORDANO TONY , STURGESS MICHAEL A , RAO SAMALA J
IPC分类号： A61K31/428 , A61K31/4709 , C07C257/18 , C07C279/18 , C07C281/18 , A61K31/16 , A61K31/34 , A61K31/425 , C07C233/05 , C07C243/20 , C07D277/62 , C07D307/78
CPC分类号： C07C257/18 , A61K31/428 , A61K31/4709 , C07C279/18 , C07C281/18 , C07C2601/14
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9.发明公开Bacterial RNaseP Proteins and their use in identifying antibacterial compounds 审中-公开细菌RNaseP蛋白及其在鉴定抗菌化合物中的用途
公开(公告)号：EP1130091A2
公开(公告)日：2001-09-05
申请号：EP01105007.7
申请日：2001-03-01
发明人： Gopalan, Venkat , Jovanovic, Milan , Eder, Paul S. , Giordano, Tony , Powers, Gordon D. , Xavier, K. Asish
CPC分类号： C12N9/22
摘要： The invention features novel RNase P molecules and nucleic acids encoding the same. Methods for discovery of antimicrobial compounds are also featured.
摘要翻译： 本发明的特征在于新的RNase P分子和编码它的核酸。 还发现了用于发现抗微生物化合物的方法。
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10.发明公开METHOD FOR IDENTIFYING COMPOUNDS AFFECTING RNA/RNA BINDING PROTEIN INTERACTIONS 有权对于RNA相互作用的化合物的检测和蛋白质的方法，结合RNA LEG河流
公开(公告)号：EP1117841A4
公开(公告)日：2002-03-13
申请号：EP99970130
申请日：1999-09-16
CPC分类号： C12Q1/6811 , C12Q2522/101
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