发明公开
- 专利标题： MODIFIED CEA AND USES THEREOF
- 专利标题（中）： 改性CEA和相关的应用
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申请号： EP01956237.0申请日： 2001-07-27
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公开(公告)号： EP1305414A2公开(公告)日： 2003-05-02
- 发明人: BERINSTEIN, Neil , TARTAGLIA, James , TINE, John, A. , PANICALI, Dennis, L. , GRITZ, Linda , SCHLOM, Jeffrey
- 申请人： Aventis Pasteur Limited , Therion Biologics , National Cancer Institute
- 申请人地址： Connaught Campus,1755 Steeles Avenue West Toronto,Ontario M2R 3T4 CA
- 专利权人： Aventis Pasteur Limited,Therion Biologics,National Cancer Institute
- 当前专利权人： Aventis Pasteur Limited,Therion Biologics,National Cancer Institute
- 当前专利权人地址： Connaught Campus,1755 Steeles Avenue West Toronto,Ontario M2R 3T4 CA
- 代理机构： Nachshen, Neil Jacob
- 优先权： US222043P 20000731
- 国际公布： WO02010379 20020207
- 主分类号： C12N15/12
- IPC分类号： C12N15/12 ; C12N15/86 ; C12N7/01 ; C12N5/10 ; C07K14/705 ; A61K38/17 ; A61K48/00
摘要：
The invention discloses immunogenic CEA agonist polypeptides/proteins comprising a modified epitope containing the amino acid sequence YLSGADLNL, nucleic acids coding therefor, vectors and/or cells comprising said nucleic acids, and mixtures and/or compositions thereof. Methods for eliciting or inducing CEA-specific immune responses utilizing the aforementioned agents are also disclosed.
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