公开(公告)号：EP4031138A1

公开(公告)日：2022-07-27

申请号：EP20774960.7

申请日：2020-09-17

申请人： Mereo Biopharma 4 Limited ,  Duke University ,  National Cancer Institute

发明人： PARKIN, Jacqueline ,  SUNG, Anthony ,  PAVLETIC, Steven. Z ,  IM, Annie ,  HOLTZMAN, Noa. G ,  PEER, Cody J.

IPC分类号： A61K31/444 ,  A61K9/00 ,  A61K45/06 ,  A61P11/00 ,  A61P37/06 ,  A61P43/00

公开(公告)号：EP1561817A2

公开(公告)日：2005-08-10

申请号：EP05004454.4

申请日：2001-07-27

申请人： Aventis Pasteur Limited ,  Therion Biologics ,  National Cancer Institute

发明人： Berinstein, Neil ,  Tartaglia, James ,  Tine, John A. ,  Panicali, Dennis L. ,  Gritz, Linda ,  Schlom, Jeffrey

IPC分类号： C12N15/12 ,  C12N15/86 ,  C12N7/01 ,  C12N5/10 ,  C07K14/705 ,  A61K38/17 ,  A61K48/00

CPC分类号： A61K38/1709 ,  A61K39/00 ,  A61K2039/5154 ,  A61K2039/5156 ,  A61K2039/5256 ,  A61K2039/53 ,  C07K14/70503

摘要： The invention discloses immunogenic CEA agonist polypeptides/proteins comprising a modified epitope containing the amino acid sequence YLSGADLNL, nucleic acids coding therefor, vectors and/or cells comprising said nucleic acids, and mixtures and/or compositions thereof. Methods for eliciting or inducing CEA-specific immune responses utilizing the aforementioned agents are also disclosed.

摘要翻译： 本发明公开了包含含有氨基酸序列YLSGADLNL的修饰表位，编码其的核酸，包含所述核酸的载体和/或细胞以及其混合物和/或组合物的免疫原性CEA激动剂多肽/蛋白质。 还公开了利用上述药剂引发或诱导CEA特异性免疫应答的方法。

公开(公告)号：EP3638816A1

公开(公告)日：2020-04-22

申请号：EP18759367.8

申请日：2018-06-12

申请人： Debreceni Egyetem ,  U.S. National Cancer Institute

发明人： BAY, Péter ,  GOEDERT, James J. ,  KOVÁCS, Tünde ,  MIKÓ, Edit ,  VIDA, András

IPC分类号： C12Q1/6886 ,  G01N33/574

公开(公告)号：EP1561817A3

公开(公告)日：2005-09-14

申请号：EP05004454.4

申请日：2001-07-27

申请人： Aventis Pasteur Limited ,  Therion Biologics ,  National Cancer Institute

发明人： Berinstein, Neil ,  Tartaglia, James ,  Tine, John A. ,  Panicali, Dennis L. ,  Gritz, Linda ,  Schlom, Jeffrey

IPC分类号： C12N15/12 ,  C12N15/86 ,  C12N7/01 ,  C12N5/10 ,  C07K14/705 ,  A61K38/17 ,  A61K48/00

CPC分类号： A61K38/1709 ,  A61K39/00 ,  A61K2039/5154 ,  A61K2039/5156 ,  A61K2039/5256 ,  A61K2039/53 ,  C07K14/70503

摘要： The invention discloses immunogenic CEA agonist polypeptides/proteins comprising a modified epitope containing the amino acid sequence YLSGADLNL, nucleic acids coding therefor, vectors and/or cells comprising said nucleic acids, and mixtures and/or compositions thereof. Methods for eliciting or inducing CEA-specific immune responses utilizing the aforementioned agents are also disclosed.

公开(公告)号：EP1305414A2

公开(公告)日：2003-05-02

申请号：EP01956237.0

申请日：2001-07-27

申请人： Aventis Pasteur Limited ,  Therion Biologics ,  National Cancer Institute

发明人： BERINSTEIN, Neil ,  TARTAGLIA, James ,  TINE, John, A. ,  PANICALI, Dennis, L. ,  GRITZ, Linda ,  SCHLOM, Jeffrey

IPC分类号： C12N15/12 ,  C12N15/86 ,  C12N7/01 ,  C12N5/10 ,  C07K14/705 ,  A61K38/17 ,  A61K48/00

CPC分类号： A61K38/1709 ,  A61K39/00 ,  A61K2039/5154 ,  A61K2039/5156 ,  A61K2039/5256 ,  A61K2039/53 ,  C07K14/70503

摘要： The invention discloses immunogenic CEA agonist polypeptides/proteins comprising a modified epitope containing the amino acid sequence YLSGADLNL, nucleic acids coding therefor, vectors and/or cells comprising said nucleic acids, and mixtures and/or compositions thereof. Methods for eliciting or inducing CEA-specific immune responses utilizing the aforementioned agents are also disclosed.

公开(公告)号：EP4186562A1

公开(公告)日：2023-05-31

申请号：EP21210650.4

申请日：2021-11-26

申请人： Vilnius University ,  National Cancer Institute

发明人： Gaubas, Eugenijus ,  Ceponis, Tomas ,  Pukas, Kornelijus ,  Rumbauskas, Vytautas ,  Uzgiryte, Milita ,  Venius, Jonas ,  Akelaitis, Kestutis ,  Cicinas, Aleksandras

IPC分类号： A61N5/10

摘要： This invention discloses a system and self-consistent method for brachytherapy procedure planning and verification. Those are based on instantaneous 3D-positioning of radionuclide emitters (5) and spatial 3D-dosimetry in a brachytherapy phantom (1), before brachytherapy in-vivo treatment. Spatial positioning and dosimetry are performed by the triangulation technique using needle-type probes being fixed in time-space-resolved coordinates, thus operating as 3D-scanner. The system (2) comprises a base-plate (10) with mesh-work (21), a plurality of catheter-installation grooves (20), and at least three needle-type scaling catheters (6) with probes internally comprising scintillator-sensors (3) as optical beacons, and dosimeters (4). The catheter (6) probes are positioned within the phantom (1) for brachytherapy planning and verification. The coordinates of 3D-scanner (3-9) are tightly linked to the base-plate (10) and the installation grooves (20) of the phantom (1) via marked labels and by RPVD means. The invention facilitates the brachytherapy planning and verification stage, wherein the obtained verification results further can be efficiently applied for brachytherapy in vivo treatment procedure, by increasing spatial precision of the therapeutic dose applied to a patient.

公开(公告)号：EP2118065A1

公开(公告)日：2009-11-18

申请号：EP07849684.1

申请日：2007-11-30

申请人： Council of Scientific & Industrial Research ,  Chitaranjan National Cancer Institute

发明人： QAZI, Ghulam, Nabi ,  SAXENA, Ajit, Kumar ,  MUTHIAH, Shanmugavel ,  MONDHE, Dilip, Manikrao ,  SHARMA, Parduman, Raj ,  SINGH, Shashank, Kumar ,  SANYAL, Utpal ,  MUKHERJEE, Asama ,  HAZRA, Suva ,  DUTTA, Susanta

IPC分类号： C07D221/14 ,  A61K31/473 ,  A61P35/00

CPC分类号： C07D221/14

摘要： The present invention relates to novel substituted 1H-benz[de]isoquinoline-1,3-diones. This invention particularly relates to novel substituted 1H-benz[de]isoquinoline-1,3-diones particularly N-[2-(Chloroethyl)]- and N-[3-(Chloropropyl)]-naphthalimides and antitumor activity thereof. The present invention also relates to process of preparation of novel substituted 1H-benz[de]isoquinoline-1,3-diones. The present invention further relates to pharmaceutical composition for the treatment of cancer and related diseases.

公开(公告)号：EP3830300A1

公开(公告)日：2021-06-09

申请号：EP19773488.2

申请日：2019-07-31

申请人： Debreceni Egyetem ,  U.S. National Cancer Institute

发明人： BAY, Péter ,  KOVÁCS, Tünde ,  MIKÓ, Edit ,  VIDA, András ,  GOEDERT, James J. ,  TÓTH, Judit ,  SEB , Éva

IPC分类号： C12Q1/6886

公开(公告)号：EP2118065B1

公开(公告)日：2013-08-14

申请号：EP07849684.1

申请日：2007-11-30

申请人： Council of Scientific & Industrial Research ,  Chitaranjan National Cancer Institute

发明人： QAZI, Ghulam, Nabi ,  SAXENA, Ajit, Kumar ,  MUTHIAH, Shanmugavel ,  MONDHE, Dilip, Manikrao ,  SHARMA, Parduman, Raj ,  SINGH, Shashank, Kumar ,  SANYAL, Utpal ,  MUKHERJEE, Asama ,  HAZRA, Suva ,  DUTTA, Susanta

IPC分类号： C07D221/14 ,  A61K31/473 ,  A61P35/00

CPC分类号： C07D221/14

公开(公告)号：EP1667631A2

公开(公告)日：2006-06-14

申请号：EP04788769.0

申请日：2004-09-15

申请人： CHIRON CORPORATION ,  National Institutes of Health, National Cancer Institute

发明人： BARNETT, Susan W. ,  GOMEZ-ROMAN, V.R., National Institutes of Health ,  LIAN, Ying ,  PENG, Bo, Nat. Inst. of Health, Nat. Cancer Inst. ,  ROBERT-GUROFF, M., National Institutes of Health ,  SRIVASTAVA, Indresh K.

IPC分类号： A61K6/00

CPC分类号： A61K39/21 ,  A61K39/00 ,  A61K39/12 ,  A61K2039/53 ,  A61K2039/54 ,  A61K2039/545 ,  A61K2039/55566 ,  A61K2039/57 ,  C07K16/1063 ,  C07K2317/21 ,  C07K2317/732 ,  C07K2317/76 ,  C12N2740/16134

摘要： The present invention relates to methods, polynucleotides, and polypeptides encoding immunogenic HIV polypeptides derived from different strains within an HIV subtype and/or immunogenic HIV polypeptides from different subtypes. Uses of the polynucleotides and polypeptides in combination approaches for generating immune responses are described. The combination approaches described herein have been shown to induce broad and potent neutralizing activity against diverse HIV strains from multiple strains within a given subtype and against diverse subtypes. Formulations of compositions for generating immune responses and methods of use for such compositions are also disclosed.