-
公开(公告)号：EP1305414A2
公开(公告)日：2003-05-02
申请号：EP01956237.0
申请日：2001-07-27
发明人： BERINSTEIN, Neil , TARTAGLIA, James , TINE, John, A. , PANICALI, Dennis, L. , GRITZ, Linda , SCHLOM, Jeffrey
CPC分类号： A61K38/1709 , A61K39/00 , A61K2039/5154 , A61K2039/5156 , A61K2039/5256 , A61K2039/53 , C07K14/70503
摘要： The invention discloses immunogenic CEA agonist polypeptides/proteins comprising a modified epitope containing the amino acid sequence YLSGADLNL, nucleic acids coding therefor, vectors and/or cells comprising said nucleic acids, and mixtures and/or compositions thereof. Methods for eliciting or inducing CEA-specific immune responses utilizing the aforementioned agents are also disclosed.
-
2.发明公开
公开(公告)号：EP1227837A1
公开(公告)日：2002-08-07
申请号：EP00971184.7
申请日：2000-10-20
CPC分类号： A61K39/0011 , A61K39/00 , A61K2039/53 , C07K14/4748 , C12N9/6494 , C12N15/86 , C12N2710/24043 , C12N2710/24071 , C12Y304/24011
摘要： An improved method of inducing and/or enhancing an immune response to a tumor antigen is disclosed. The method involves administering the tumor antigen, nucleic acid coding therefor, vectors and/or cells comprising said nucleic acid, or vaccines comprising the aforementioned to a lymphatic site.
-
公开(公告)号：EP1108035A2
公开(公告)日：2001-06-20
申请号：EP99942661.2
申请日：1999-09-03
发明人： GAJEWCZYK, Diane, M. , PERSSON, Roy , YAO, Fei-Long , CAO, Shi-Xian , KLEIN, Michel, H. , TARTAGLIA, James , MOINGEON, Phillipe , ROVINSKI, Benjamin
IPC分类号： C12N15/37 , C12N15/86 , C07K14/025 , A61K48/00
CPC分类号： A61B5/055 , A61B5/0263 , A61B5/029 , A61B5/41 , A61K48/00 , A61K2039/51 , A61K2039/53 , C07K14/005 , C12N2710/20022 , C12N2710/20043 , Y10S977/804 , Y10S977/904 , Y10S977/916 , Y10S977/924
摘要： Vectors for DNA immunization against cervical cancer comprise a nucleic acid molecule encoding at least one none-toxic T-cell epitope of the E6 and/or E7 antigens of a strain of human papilloma virus (HPV) associated with cervical cancer, such as HPV-16, and a promoter operatively coupled to the nucleic acid molecule for expression of the nucleic acid molecule in a host to which the vector is administered.
-
4.发明授权
公开(公告)号：EP1227837B1
公开(公告)日：2008-05-21
申请号：EP00971184.7
申请日：2000-10-20
CPC分类号： A61K39/0011 , A61K39/00 , A61K2039/53 , C07K14/4748 , C12N9/6494 , C12N15/86 , C12N2710/24043 , C12N2710/24071 , C12Y304/24011
摘要： An improved method of inducing and/or enhancing an immune response to a tumor antigen is disclosed. The method involves administering the tumor antigen, nucleic acid coding therefor, vectors and/or cells comprising said nucleic acid, or vaccines comprising the aforementioned to a lymphatic site.
-
公开(公告)号：EP1280551A2
公开(公告)日：2003-02-05
申请号：EP01927532.0
申请日：2001-04-25
IPC分类号： A61K39/12
CPC分类号： C07K14/005 , A61K39/12 , A61K39/21 , A61K2039/5258 , A61K2039/53 , A61K2039/54 , A61K2039/545 , A61K2039/55505 , A61K2039/55577 , C12N2710/24043 , C12N2740/16122 , C12N2740/16134
摘要： A virus neutralizing level of antibodies to a primary HIV isolate is generated in a host by a prime-boost administration of antigents. The primary antigen is a DNA molecule encoding an envelop glycoprotein of a primary isolate of HIV-1 while the boosting antigen is either a non-infectious, non-replicating HIV-like particle having the envelope glycoprotein of a primary isolate of HIV-1 or an attenuated viral vector expressing an envelope glycoprotein of a primary isolate of HIV-1.
-
公开(公告)号：EP1228095A1
公开(公告)日：2002-08-07
申请号：EP00971185.4
申请日：2000-10-20
CPC分类号： A61K39/0011 , A61K39/00 , A61K2039/53 , C07K14/4748 , C12N9/6494 , C12N15/86 , C12N2710/24043 , C12N2710/24071 , C12Y304/24011
摘要： A gp100 molecule useful in modulating the immune system is described. In particular what is described is a nucleotide sequence for a gp100 which has been modified so as to be useful in modulating the immune system. The isolated nucleic acid sequence is described and referred to as gp100M. The corresponding protein, referred to as gp100M, is also described. Applications of the molecules as vaccines are described.
-
-
-
-
-
搜索结果
6 条记录 (耗时 0.014 秒)
