发明公开
- 专利标题： NOVEL PHYSIOLOGICALLY ACTIVE SUBSTANCES
- 专利标题（中）： NEUE PHYSIOLOGISCH WIRKSAME SUBSTANZEN
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申请号： EP02711280.4申请日： 2002-02-01
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公开(公告)号： EP1380579A1公开(公告)日： 2004-01-14
- 发明人: MIZUI, Yoshiharu , SAKAI, Takashi , YAMAMOTO, Satoshi , KOMEDA, Keisuke , FUJITA, Masanori , OKUDA, Akifumi , KISHI, Kumiko , NIIJIMA, Jun , NAGAI, Mitsuo , OKAMOTO, Kiyoshi , IWATA, Masao , KOTAKE, Yoshihiko , UENAKA, Toshimitsu , ASAI, Naoki , MATSUFUJI, Motoko , SAMESHIMA, Tomohiro , KAWAMURA, Naoto , DOBASHI, Kazuyuki , NAKASHIMA, Takashi , YOSHIDA, Masashi , TSUCHIDA, Toshio , TAKEDA, Susumu , YAMADA, Tomonari , NORIHISA, Koji , YAMORI, Takao
- 申请人： MERCIAN CORPORATION , Eisai Co., Ltd.
- 申请人地址： 5-8, Kyobashi 1-chome Chuo-ku, Tokyo 104-8305 JP
- 专利权人： MERCIAN CORPORATION,Eisai Co., Ltd.
- 当前专利权人： MERCIAN CORPORATION,Eisai Co., Ltd.
- 当前专利权人地址： 5-8, Kyobashi 1-chome Chuo-ku, Tokyo 104-8305 JP
- 代理机构： HOFFMANN - EITLE
- 优先权： JP2001025458 20010201
- 国际公布： WO2002060890 20020808
- 主分类号： C07D313/00
- IPC分类号： C07D313/00 ; C07D405/14 ; C07D407/06 ; C07D493/10 ; C07D493/04 ; A61K31/335 ; A61K31/336 ; A61K31/4427 ; A61K31/4523 ; A61K31/455 ; A61K31/4025 ; A61K31/5377 ; A61K31/496 ; A61K31/74 ; A61P43/00 ; A61P7/00 ; A61P35/00 ; A61P35/04 ; A61P29/00 ; A61P19/02 ; A61P27/02
摘要：
The presentinvention provides a novel bioactive substance having an antitumor activity and a process for producing it, and a medical use thereof. Namely, it provides a 12-membered ring macrolide compound represented by the following formula obtained from the incubation solution of Streptomyces sp. Mer. 11107 or a variant thereof, a pharmacologically acceptable salt thereof or a hydrate of them, and a process for producing it.
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