发明公开
- 专利标题: HYDROXYFATTYSULFONIC ACID ANALOGS
- 专利标题(中): HYDROXYFETTSULFONSÄUREANALOGA
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申请号: EP02761382申请日: 2002-09-09
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公开(公告)号: EP1436252A4公开(公告)日: 2005-02-09
- 发明人: FALCK JOHN R , MIYATA NORIYUKI , ONO NAOYA , CHONAN TOMOMICHI , HIRANO HITOMI , TODA YOSHIHISA , TANAMI TOHRU , OKUYAMA SHIGERU
- 申请人: TAISHO PHARMA CO LTD , UNIV TEXAS
- 专利权人: TAISHO PHARMA CO LTD,UNIV TEXAS
- 当前专利权人: TAISHO PHARMA CO LTD,UNIV TEXAS
- 优先权: US31887401 2001-09-14
- 主分类号: C07D277/20
- IPC分类号: C07D277/20 ; A61K31/047 ; A61K31/08 ; A61K31/16 ; A61K31/18 ; A61K31/185 ; A61K31/201 ; A61K31/231 ; A61K31/275 ; A61K31/41 ; A61K31/426 ; A61P1/02 ; A61P1/04 ; A61P1/16 ; A61P1/18 ; A61P7/02 ; A61P9/00 ; A61P9/10 ; A61P11/00 ; A61P11/06 ; A61P11/08 ; A61P13/12 ; A61P15/00 ; A61P15/06 ; A61P17/02 ; A61P17/06 ; A61P19/00 ; A61P19/02 ; A61P27/02 ; A61P29/00 ; A61P31/00 ; A61P31/04 ; A61P37/02 ; A61P37/06 ; A61P43/00 ; C07C33/04 ; C07C33/044 ; C07C33/42 ; C07C59/01 ; C07C59/42 ; C07C59/46 ; C07C59/60 ; C07C69/708 ; C07C69/732 ; C07C235/28 ; C07C255/15 ; C07C255/16 ; C07C259/06 ; C07C309/08 ; C07C309/10 ; C07C309/20 ; C07C309/23 ; C07C309/24 ; C07C309/68 ; C07C311/04 ; C07C311/17 ; C07C311/51 ; C07C317/44 ; C07C323/52 ; C07C323/66 ; C07D257/04 ; C07D277/34 ; C07C309/01 ; C07C303/36 ; C07C309/02 ; C07C309/03 ; C07C309/04 ; C07C309/07 ; C07C309/63 ; C07C309/64 ; C07C309/65 ; C07C309/67
摘要:
A hydroxyfattysulfonic acid analog represented by Formula (I): wherein X is an ethylene group, a vinylene group or an ethynylene group; Y is an ethylene group, a vinylene group, an ethynylene group, OCH2 or S(O)pCH2 wherein p is 0, 1 or 2; m is an integer of 1 to 5 inclusive; n is an integer of 0 to 4 inclusive;R1 is a C¿1-8? alkyl group, a C3-8 cycloalkyl group, a C1-4 alkyl group substituted with a C3-8 cycloalkyl group, a C1-4 alkyl group substituted with an aryl group or a C1-4 alkyl group substituted with an aryloxy group; R?2¿ is a hydrogen atom or a methyl group; R?1 and R2¿ together with the carbon atom to which they are attached may form a C¿3-8? cycloalkyl group; R?3¿ is a hydrogen atom or a C¿2-8? acyl group; R?4 is OR5 or NHR6¿, wherein R5 is a hydrogen atom, a C¿1-4? alkyl group, an alkali metal, an alkaline earth metal or an ammonium group and R?6¿ is a hydrogen atom or a C¿1-4? alkyl group; or a pharmaceutically acceptable salt or a hydrate thereof. The compounds of the present invention are useful as an elastase release inhibitor.
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