发明公开
EP1441758A2 ALLOGENE VAKZINE ENTHALTEND EINE EIN COSTIMULATORISCHES POLYPEPTID EXPRIMIERENDE TUMORZELLE
审中-公开
同种异体疫苗包含共刺激表达多肽的肿瘤细胞
- 专利标题: ALLOGENE VAKZINE ENTHALTEND EINE EIN COSTIMULATORISCHES POLYPEPTID EXPRIMIERENDE TUMORZELLE
- 专利标题(英): Allogenic vaccine that contains a costimulatory polypeptide-expressing tumor cell
- 专利标题(中): 同种异体疫苗包含共刺激表达多肽的肿瘤细胞
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申请号: EP02787620.0申请日: 2002-11-08
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公开(公告)号: EP1441758A2公开(公告)日: 2004-08-04
- 发明人: NIELAND, John , BREIDENSTEIN, Claudia , SARTORIUS, Ute , MOEBIUS, Ulrich , BOGEDAIN, Christoph , DINKEL, Adelheid
- 申请人: MediGene Aktiengesellschaft
- 申请人地址: Lochhamer Strasse 11 82152 Planegg/Martinsried DE
- 专利权人: MediGene Aktiengesellschaft
- 当前专利权人: MediGene Aktiengesellschaft
- 当前专利权人地址: Lochhamer Strasse 11 82152 Planegg/Martinsried DE
- 代理机构: Bösl, Raphael, Dr.rer.nat., Dipl.-Chem.
- 优先权: US332497P 20011109
- 国际公布: WO2003039591 20030515
- 主分类号: A61K39/00
- IPC分类号: A61K39/00 ; A61K39/39 ; A61P35/00
摘要:
The invention relates to the use of a tumor cell for producing a vaccine for the treatment or prophylaxis of tumors in patients, said tumor cell expressing a costimulatory polypeptide and said tumor cell and said patient having non-identical MHC molecules. The invention further relates to the use of a costimulatory polypeptide-expressing tumor cell for producing a vaccine for increasing the lytic activity of NK cells in the treatment or prophylaxis of a tumor in a patient that is allogenic with respect to the tumor cell.
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