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1.发明公开Strukturprotein von Adeno-assoziiertem Virus mit veränderter Antigenität, seine Herstellung und Verwendung 审中-公开Strukturprotein von Adeno-assoziiertem Virus mitveränderterAntigenität，seine Herstellung und Verwendung
公开(公告)号：EP2060634A1
公开(公告)日：2009-05-20
申请号：EP08022398.5
申请日：2000-07-13
发明人： Hallek, Michael , Girod, Anne , Ried, Martin
IPC分类号： C12N15/864 , C12N15/35 , C12N15/62 , C07K14/015 , C12N5/10 , A61K39/23 , A61K48/00
CPC分类号： C12N15/86 , A61K48/00 , C07K14/005 , C07K2319/00 , C12N2750/14122 , C12N2750/14143
摘要： Die vorliegende Erfindung betrifft ein Strukturprotein von Adeno-assoziiertem Virus (AAV), das mindestens eine Modifikation enthält, die eine Verringerung der Antigenität bewirkt, seine Herstellung und Verwendung.
摘要翻译： 腺病毒（AAV）结构蛋白（I），其包含至少一种降低病毒毒力的突变。 还包括独立权利要求：（1）编码（I）的核酸（II）; （2）包含（II）的宿主细胞（III）; （3）生产（I）包括：（i）培养（III）; 和（ii）分离（I）; 和（4）由（I）和合适的药物载体组成的药物组合物。 活动：细胞抑制。 作用机制：基因治疗。
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2.发明公开
公开(公告)号：EP1373237A1
公开(公告)日：2004-01-02
申请号：EP02727511.4
申请日：2002-03-28
IPC分类号： C07D303/48 , C07D207/16
CPC分类号： C07D265/30 , C07D303/48
摘要： The invention relates to methods for producing oxirane carboxylic acids and derivatives thereof, particularly to methods that are conducted under stereochemical control of the reaction steps, to the inventively produced oxirane carboxylic acids and derivatives thereof, and to their use in pharmaceutical compositions, particularly for treating hyperlipidemia.
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公开(公告)号：EP0968277A1
公开(公告)日：2000-01-05
申请号：EP98913653.6
申请日：1998-03-05
IPC分类号： C12N7/02
CPC分类号： B01D61/145 , A61K48/00 , C12N7/00 , C12N15/86 , C12N2710/10322 , C12N2710/10343 , C12N2710/10351 , C12N2750/14143 , C12N2750/14151
摘要： The invention relates to a filtration method for separating viruses of various sizes, wherein the solution containing said viruses is preferably filtered by one or several filtering membranes.
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4.发明公开PAPILLOMAVIRUSÄHNLICHE PARTIKEL, FUSIONSPROTEINE SOWIE VERFAHREN ZU DEREN HERSTELLUNG 失效粒子乳头状瘤病毒，融合蛋白及其制备方法
公开(公告)号：EP0809700A1
公开(公告)日：1997-12-03
申请号：EP95934663.0
申请日：1995-10-09
申请人： MediGene Aktiengesellschaft , Gissmann, Lutz , Zhou, Jian , Müller, Martin , Painstil, Jeanette
发明人： GISSMANN, Lutz , ZHOU, Jian , MÜLLER, Martin , PAINSTIL, Jeanette
IPC分类号： C12N15 , A61K39 , A61P13 , A61P15 , A61P31 , C07K14 , C07K19 , C12N7 , C12P21 , A61K38 , C12R1
CPC分类号： C07K14/005 , A61K38/00 , A61K39/12 , A61K2039/5256 , A61K2039/5258 , C07K2319/00 , C12N7/00 , C12N2710/20022 , C12N2710/20023 , C12N2710/20034
摘要： Recombinant papilloma virus-like particles result from the expression of viral structural proteins L1 and/or L2 in which one or several sections of the L1 and/or L2 protein are deleted. The ability to form virus-like particles is at least the same as, preferably higher than, that of native reproduction and/or in vitro production processes.
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5.发明公开OPTIMIERTE HERSTELLUNG VON VIRALEN, VON PARVOVIREN ABGELEITETEN VEKTOREN IN VERPACKUNGS- UND PRODUKTIONSZELLEN DURCH HSV-INFEKTION ODER BEHANDLUNG MIT INHIBITOREN DER DNA-METHYLIERUNG 审中-公开病毒性产生增加，细小病毒衍生的载体包装和生产细胞HSV感染或治疗的DNA甲基化抑制剂
公开(公告)号：EP1448782A1
公开(公告)日：2004-08-25
申请号：EP02787878.4
申请日：2002-11-29
发明人： HÖRER, Markus , DUBIELZIG, Ralf
CPC分类号： C12N15/86 , A61K48/00 , C07K14/005 , C12N7/00 , C12N9/1007 , C12N2710/16622 , C12N2750/14121 , C12N2750/14143 , C12N2750/14152
摘要： The invention relates to uses and methods enabling the production yield of viral vectors derived from piroviruses to be improved by using DNA methylation inhibitors and/or Herpes viruses in the production of viral vectors derived from parvoviruses.
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公开(公告)号：EP1441759A2
公开(公告)日：2004-08-04
申请号：EP02802659.9
申请日：2002-11-08
CPC分类号： A61K39/0011 , A61K2039/5152 , A61K2039/5156 , A61K2039/55516 , A61K2039/55522 , A61K2039/55561 , A61K2039/57
摘要： The invention relates to a composition for vaccination against tumours containing at least one tumour cell, which expresses at least one cytokine, chemokine and/or a co-stimulating molecule and an effective quantity of at least one adjuvant. The invention also relates to the use of a composition of this type for producing a medicament for the treatment or prevention of tumours.
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7.发明公开
公开(公告)号：EP1244772A2
公开(公告)日：2002-10-02
申请号：EP00990011.9
申请日：2000-12-21
发明人： RÖNICKE, Volker , NAVE, Barbara , HENKEL, Thomas
CPC分类号： C12N5/0657 , C12N2501/235 , C12N2501/365 , C12N2501/999 , C12N2503/02 , G01N33/5014 , G01N2500/10
摘要： The invention relates to a pathologically modified myocardial cell which can be produced from healthy cardiac tissue by providing or isolating at least one healthy myocardial cell, by stimulating said isolated myocardial cell using the appropriate hormones, hormone analogues and/or zytokines and by detecting the pathologically modified myocardial cell(s) by localising at least one signal molecule. The invention also relates to a method for producing said pathologically modified myocardial cell and to the use thereof, including a method for detecting or identifying cardioactive substances.
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8.发明公开ZYTOTOXISCHE T-ZELLEPITOPE DES PAPILLOMAVIRUS L1-PROTEINS UND IHRE VERWENDUNG IN DIAGNOSTIK UND THERAPIE 审中-公开乳头瘤病毒L1蛋白的细胞毒性T细胞表位和它们在诊断与治疗
公开(公告)号：EP1181312A1
公开(公告)日：2002-02-27
申请号：EP00940295.9
申请日：2000-05-31
发明人： JOCHMUS, Ingrid , NIELAND, John
IPC分类号： C07K14/025
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , C12N2710/20022
摘要： The invention relates to a papilloma virus T-cell epitope with an amino acid sequence ILVPKVSGL, RLVWACVGV, HLFNRAGTV, YLRREQMFV, TLQANKSEV, ILEDWNFGL, SLWLPSEATVYL, NLASSNYFPT, TLTADVMTYI, YLPPVPVSKV, YDLQFIFQL, ICWGNQLFV, FYNPDTQRL, MHGDTPTLH, ETTDLYCY, QAEPDRAHYN, SMVTSDAQI, and/or a functionally active variant thereof. The invention also relates to the use thereof in diagnosis and therapy.
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公开(公告)号：EP1088075A2
公开(公告)日：2001-04-04
申请号：EP99929292.3
申请日：1999-06-21
发明人： HALLEK, Michael , RIED, Martin , DELEAGE, Gilbert , GIROD, Anne
IPC分类号： C12N15/35 , C12N15/62 , C07K14/015 , C12N5/10 , A61K39/23 , A61K48/00 , G01N33/68 , C12Q1/68
CPC分类号： C07K14/005 , A61K38/00 , A61K48/00 , C12N2750/14122
摘要： The invention relates to an AAV (Adeno-associated virus) scleroprotein, containing at least one mutation that increases the infectiousness of the virus.
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公开(公告)号：EP1007970A1
公开(公告)日：2000-06-14
申请号：EP98943805.6
申请日：1998-07-30
IPC分类号： G01N33/569 , G01N33/574 , C07K14/025
CPC分类号： G01N33/56983 , A61K49/0006 , G01N2333/025
摘要： A skin test was developed to determine the immune status with regard to viral proteins E6 and E7 from the human papillomavirus. For that purpose, a diagnostic kit is provided which contains an active amount or at least an immunologically active fraction of the proteins E6 and/or E7. Said test consists in intracutaneaous application of the protein E6/E7 and visual examination of the skin portion concerned in an attempt for detecting red spots.
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