发明公开
EP1480687A1 COMPOSE PHOSPHOCALCIQUE MODIFIE, COMPOSITION INJECTABLE LE CONTENANT
有权
改性钙磷酸盐化合物和组合物含有该注射用
- 专利标题： COMPOSE PHOSPHOCALCIQUE MODIFIE, COMPOSITION INJECTABLE LE CONTENANT
- 专利标题（英）： Modified phosphocalcic compound, injectable composition containing same
- 专利标题（中）： 改性钙磷酸盐化合物和组合物含有该注射用
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申请号： EP03717407.5申请日： 2003-02-18
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公开(公告)号： EP1480687A1公开(公告)日： 2004-12-01
- 发明人: BUJOLI, Bruno , JOSSE, Solen , GUICHEUX, Jérôme , JANVIER, Pascal , BOULER, Jean-Michel , DACULSI, Guy
- 申请人： Centre National de la Recherche Scientifique , Universite de Nantes , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
- 申请人地址： 3, Avenue Michel Ange 75016 Paris FR
- 专利权人： Centre National de la Recherche Scientifique,Universite de Nantes,INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
- 当前专利权人： Centre National de la Recherche Scientifique,Universite de Nantes,INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
- 当前专利权人地址： 3, Avenue Michel Ange 75016 Paris FR
- 代理机构： Sueur, Yvette
- 优先权： FR0202707 20020304
- 国际公布： WO2003074098 20030912
- 主分类号： A61L27/12
- IPC分类号： A61L27/12 ; A61L27/54
摘要：
The invention concerns a phosphocalcic compound modified by a gem-bisphosphonic acid or one of its salts, a method for preparing same, as well as its use for preparing an injectable composition. The modified phosphocalcic compound is obtained by adding a gem-bisphosphonic acid or one of its alkali metal or alkaline earth salts to a suspension of a precursor phosphocalcic compound in ultra-pure water, while stirring the reaction medium at room temperature, then in recovering by centrifuging the formed compound. Said compound is useful for making an injectable composition, for use in the treatment of bone remodeling equilibrium.
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