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公开(公告)号：EP1480687B1
公开(公告)日：2009-02-11
申请号：EP03717407.5
申请日：2003-02-18
申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , UNIVERSITE DE NANTES , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
发明人： BUJOLI, Bruno , JOSSE, Solen , GUICHEUX, Jérôme , JANVIER, Pascal , BOULER, Jean-Michel , DACULSI, Guy
CPC分类号： A61L27/12 , A61L27/54 , A61L2300/216 , A61L2300/432 , A61L2300/602
摘要： The invention concerns a phosphocalcic compound modified by a gem-bisphosphonic acid or one of its salts, a method for preparing same, as well as its use for preparing an injectable composition. The modified phosphocalcic compound is obtained by adding a gem-bisphosphonic acid or one of its alkali metal or alkaline earth salts to a suspension of a precursor phosphocalcic compound in ultra-pure water, while stirring the reaction medium at room temperature, then in recovering by centrifuging the formed compound. Said compound is useful for making an injectable composition, for use in the treatment of bone remodeling equilibrium.
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公开(公告)号：EP1480687A1
公开(公告)日：2004-12-01
申请号：EP03717407.5
申请日：2003-02-18
申请人： Centre National de la Recherche Scientifique , Universite de Nantes , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
发明人： BUJOLI, Bruno , JOSSE, Solen , GUICHEUX, Jérôme , JANVIER, Pascal , BOULER, Jean-Michel , DACULSI, Guy
CPC分类号： A61L27/12 , A61L27/54 , A61L2300/216 , A61L2300/432 , A61L2300/602
摘要： The invention concerns a phosphocalcic compound modified by a gem-bisphosphonic acid or one of its salts, a method for preparing same, as well as its use for preparing an injectable composition. The modified phosphocalcic compound is obtained by adding a gem-bisphosphonic acid or one of its alkali metal or alkaline earth salts to a suspension of a precursor phosphocalcic compound in ultra-pure water, while stirring the reaction medium at room temperature, then in recovering by centrifuging the formed compound. Said compound is useful for making an injectable composition, for use in the treatment of bone remodeling equilibrium.
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公开(公告)号：EP1689461A1
公开(公告)日：2006-08-16
申请号：EP04805394.6
申请日：2004-11-04
CPC分类号： C12N5/0655 , A61L27/3817 , A61L27/3852 , C12N2533/30
摘要： The invention relates to the use of a silanised hydroxypropylmethylcellulose (HPMC) or silanised hydroxyethylcellulose (HEC) hydrogel, self-crosslinking as a function of pH, for the three-dimensional ex vivo culture of chondrocytes.
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公开(公告)号：EP1689461B9
公开(公告)日：2007-08-29
申请号：EP04805394.6
申请日：2004-11-04
IPC分类号： A61L27/38
CPC分类号： C12N5/0655 , A61L27/3817 , A61L27/3852 , C12N2533/30
摘要： The invention relates to the use of a silanised hydroxypropylmethylcellulose (HPMC) or silanised hydroxyethylcellulose (HEC) hydrogel, self-crosslinking as a function of pH, for the three-dimensional ex vivo culture of chondrocytes.
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5.发明授权UTILISATION D'UN HYDROGEL POUR LA CULTURE DE CHONDROCYTES 有权利用德国联合利华水电POUR LA CULTURE DE CHONDROCYTES
公开(公告)号：EP1689461B1
公开(公告)日：2007-05-02
申请号：EP04805394.6
申请日：2004-11-04
IPC分类号： A61L27/38
CPC分类号： C12N5/0655 , A61L27/3817 , A61L27/3852 , C12N2533/30
摘要： The invention relates to the use of a silanised hydroxypropylmethylcellulose (HPMC) or silanised hydroxyethylcellulose (HEC) hydrogel, self-crosslinking as a function of pH, for the three-dimensional ex vivo culture of chondrocytes.
摘要翻译： 本发明涉及作为pH的函数的硅烷化羟丙基甲基纤维素（HPMC）或硅烷化羟乙基纤维素（HEC）水凝胶的自交联用于软骨细胞的三维离体培养的用途。
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公开(公告)号：EP3878891A1
公开(公告)日：2021-09-15
申请号：EP20162062.2
申请日：2020-03-10
申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE -CNRS- , INSERM (Institut National de la Santé et de la Recherche Médicale) , Université de Nantes
摘要： The present invention provides crosslinking pairs of hydrogel precursor polymers, dynamic covalent hydrogels prepared from such crosslinking pairs of hydrogel precursors, pharmaceutical compositions comprising such precursors or hydrogels and uses thereof in a variety of applications.
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公开(公告)号：EP4118136A1
公开(公告)日：2023-01-18
申请号：EP21711222.6
申请日：2021-03-10
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公开(公告)号：EP2714891B1
公开(公告)日：2019-11-13
申请号：EP12725754.1
申请日：2012-06-04
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9.发明公开SILYLATED BIOMOLECULE-BASED HYDROGEL FOR CULTURING CARDIOMYOCYTES AND STEM CELLS, AND USE OF THE HYDROGEL THEREOF FOR TREATING HEART FAILURE 审中-公开硅烷化BIOMOLEKÜLBASIERTES水凝胶为培养心肌干细胞和水凝胶的用于治疗心力衰竭
公开(公告)号：EP2714891A1
公开(公告)日：2014-04-09
申请号：EP12725754.1
申请日：2012-06-04
申请人： Institut National de la Santé et de la Recherche Médicale (INSERM) , Universite de Nantes , CHU Nantes
摘要： The present invention relates to the use of an hydrogel comprising silylated biomolecule for the three-dimensional culture of cardiomyocytes or stem cells which are able to differentiate into cardiomyocytes, and to an aqueous composition comprising i) cardiomyocytes or stem cells which are able to differentiate into cardiomyocytes, and ii) a hydrogel comprising silylated biomolecule, for use for treating heart failure, in particular heart failure following myocardial infarction.
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