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公开(公告)号：EP1480687B1
公开(公告)日：2009-02-11
申请号：EP03717407.5
申请日：2003-02-18
申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , UNIVERSITE DE NANTES , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
发明人： BUJOLI, Bruno , JOSSE, Solen , GUICHEUX, Jérôme , JANVIER, Pascal , BOULER, Jean-Michel , DACULSI, Guy
CPC分类号： A61L27/12 , A61L27/54 , A61L2300/216 , A61L2300/432 , A61L2300/602
摘要： The invention concerns a phosphocalcic compound modified by a gem-bisphosphonic acid or one of its salts, a method for preparing same, as well as its use for preparing an injectable composition. The modified phosphocalcic compound is obtained by adding a gem-bisphosphonic acid or one of its alkali metal or alkaline earth salts to a suspension of a precursor phosphocalcic compound in ultra-pure water, while stirring the reaction medium at room temperature, then in recovering by centrifuging the formed compound. Said compound is useful for making an injectable composition, for use in the treatment of bone remodeling equilibrium.
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公开(公告)号：EP1480687A1
公开(公告)日：2004-12-01
申请号：EP03717407.5
申请日：2003-02-18
申请人： Centre National de la Recherche Scientifique , Universite de Nantes , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
发明人： BUJOLI, Bruno , JOSSE, Solen , GUICHEUX, Jérôme , JANVIER, Pascal , BOULER, Jean-Michel , DACULSI, Guy
CPC分类号： A61L27/12 , A61L27/54 , A61L2300/216 , A61L2300/432 , A61L2300/602
摘要： The invention concerns a phosphocalcic compound modified by a gem-bisphosphonic acid or one of its salts, a method for preparing same, as well as its use for preparing an injectable composition. The modified phosphocalcic compound is obtained by adding a gem-bisphosphonic acid or one of its alkali metal or alkaline earth salts to a suspension of a precursor phosphocalcic compound in ultra-pure water, while stirring the reaction medium at room temperature, then in recovering by centrifuging the formed compound. Said compound is useful for making an injectable composition, for use in the treatment of bone remodeling equilibrium.
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3.发明授权
公开(公告)号：EP2117612B1
公开(公告)日：2015-07-29
申请号：EP08716830.8
申请日：2008-02-13
发明人： BOULER, Jean-Michel , BUJOLI, Bruno , JANVIER, Pascal , KHAIROUN, Ibrahim , ARGENSON, Jean-Noël
CPC分类号： A61L27/12 , A61L24/001 , A61L24/0063 , A61L24/02 , A61L27/20 , A61L27/50 , A61L27/54 , A61L2400/06 , A61L2430/02
摘要： The present invention relates to a macroporous, resorbable and injectable apatitic calcium-phosphate cement with a high compressive strength useful as bone cement and releasing a bone resorption inhibitor, preparation method and uses thereof.
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4.发明公开
公开(公告)号：EP2117612A1
公开(公告)日：2009-11-18
申请号：EP08716830.8
申请日：2008-02-13
发明人： BOULER, Jean-Michel , BUJOLI, Bruno , JANVIER, Pascal , KHAIROUN, Ibrahim , ARGENSON, Jean-Noël
CPC分类号： A61L27/12 , A61L24/001 , A61L24/0063 , A61L24/02 , A61L27/20 , A61L27/50 , A61L27/54 , A61L2400/06 , A61L2430/02
摘要： The present invention relates to a macroporous, resorbable and injectable apatitic calcium-phosphate cement with a high compressive strength useful as bone cement and releasing a bone resorption inhibitor, preparation method and uses thereof.
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公开(公告)号：EP2117612B2
公开(公告)日：2018-11-21
申请号：EP08716830.8
申请日：2008-02-13
发明人： BOULER, Jean-Michel , BUJOLI, Bruno , JANVIER, Pascal , KHAIROUN, Ibrahim , ARGENSON, Jean-Noël
CPC分类号： A61L27/12 , A61L24/001 , A61L24/0063 , A61L24/02 , A61L27/20 , A61L27/50 , A61L27/54 , A61L2400/06 , A61L2430/02
摘要： The present invention relates to a macroporous, resorbable and injectable apatitic calcium-phosphate cement with a high compressive strength useful as bone cement and releasing a bone resorption inhibitor, preparation method and uses thereof.
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公开(公告)号：EP3999136A1
公开(公告)日：2022-05-25
申请号：EP20740033.4
申请日：2020-07-17
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公开(公告)号：EP2403544A1
公开(公告)日：2012-01-11
申请号：EP10706257.2
申请日：2010-03-03
发明人： BUJOLI, Bruno , BOULER, Jean-Michel , JANVIER, Pascal , KHAIROUN, Ibrahim , SCHNITZLER, Verena , MELLIER, Charlotte
CPC分类号： A61L24/0042 , A61L24/0063 , A61L27/12 , A61L27/46 , A61L27/58 , C01B25/32 , C01B25/45 , C04B35/447
摘要： The present invention relates to a galliated calcium-phosphate biomaterial comprising a gallium-doped phosphocalcic compound of formula (I): €ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒCa (10.5-1.5x) Ga x (PO 4 ) 7 €ƒ€ƒ€ƒ€ƒ€ƒ(I) wherein 0
摘要翻译： 本发明涉及包含式（I）的掺杂镓的磷酸钙化合物的切片磷酸钙生物材料：€ƒ€ƒ€ƒ€ƒ€ƒCa（10.5-1.5x）Ga x（PO 4）其中0
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公开(公告)号：EP2403544B1
公开(公告)日：2018-11-14
申请号：EP10706257.2
申请日：2010-03-03
发明人： BUJOLI, Bruno , BOULER, Jean-Michel , JANVIER, Pascal , KHAIROUN, Ibrahim , SCHNITZLER, Verena , MELLIER, Charlotte
CPC分类号： A61L24/0042 , A61L24/0063 , A61L27/12 , A61L27/46 , A61L27/58 , C01B25/32 , C01B25/45 , C04B35/447
摘要： The present invention relates to a galliated calcium-phosphate biomaterial comprising a gallium-doped phosphocalcic compound of formula (I): €ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒCa (10.5-1.5x) Ga x (PO 4 ) 7 €ƒ€ƒ€ƒ€ƒ€ƒ(I) wherein 0
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公开(公告)号：EP2403543B1
公开(公告)日：2016-06-15
申请号：EP10706005.5
申请日：2010-03-03
CPC分类号： A61L24/0042 , A61L24/0063 , A61L27/12 , A61L27/46 , A61L27/58 , C01B25/32 , C01B25/45 , C04B35/447
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公开(公告)号：EP2403543A1
公开(公告)日：2012-01-11
申请号：EP10706005.5
申请日：2010-03-03
CPC分类号： A61L24/0042 , A61L24/0063 , A61L27/12 , A61L27/46 , A61L27/58 , C01B25/32 , C01B25/45 , C04B35/447
摘要： The present invention relates to a gallium-doped phosphocalcic compound of formula (I): Ca
(10.5-1.5x) Ga
x (PO
4 )
7 , wherein 0
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