发明公开
EP1571142A1 Novel anti-inflammatory and analgesic heterocyclic amidines that inhibit nitrogen oxide (NO) production
有权
Neueantientzündlicheund analgetische heterozyklische Amidine，die die Produktion von Stickstoffmonoxid（NO）inhibitioni
- 专利标题： Novel anti-inflammatory and analgesic heterocyclic amidines that inhibit nitrogen oxide (NO) production
- 专利标题（中）： Neueantientzündlicheund analgetische heterozyklische Amidine，die die Produktion von Stickstoffmonoxid（NO）inhibitioni
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申请号： EP05101498.3申请日： 2005-02-28
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公开(公告)号： EP1571142A1公开(公告)日： 2005-09-07
- 发明人: Makovec, Francesco , Giordani, Antonio , Artusi, Roberto , Mandelli, Stefano , Verpilio, Ilario , Zanzola, Simona , Rovati, Lucio Claudio
- 申请人： ROTTAPHARM S.P.A.
- 申请人地址： Galleria Unione 5 20122 Milano IT
- 专利权人： ROTTAPHARM S.P.A.
- 当前专利权人： ROTTAPHARM S.P.A.
- 当前专利权人地址： Galleria Unione 5 20122 Milano IT
- 代理机构： Rambelli, Paolo
- 优先权： ITTO20040125 20040301
- 主分类号： C07D209/08
- IPC分类号： C07D209/08 ; C07D215/38 ; C07D217/02 ; C07D235/10 ; C07D235/12 ; C07D237/28 ; C07D239/74 ; C07D263/57 ; C07D277/66 ; C07D307/79 ; C07D333/54 ; C07D403/04 ; C07D405/04 ; C07D409/04 ; C07D417/04 ; A61K31/343 ; A61K31/381 ; A61K31/404 ; A61K31/4184 ; A61K31/423 ; A61K31/428 ; A61K31/47 ; A61K31/472 ; A61K31/502 ; A61K31/517 ; A61P29/00
摘要：
Heterocyclic amidines with anti-inflammatory and analgesic activity that inhibit nitrogen oxide production, of formula (I):
in which:
G 1 and G 2 are hydrogen, halogen, hydroxyl, C 1 -C 4 alkoxy, C 1 -C 4 alkyl, and an amidino substituent of formula Q, provided that, for each compound of formula (I), only one of the two substituents G 1 or G 2 is an amidino substituent of formula Q:
and in which the substituents W, Y and X are combined to form 9- or 10-membered bicyclic heteroaromatic derivatives containing up to 2 hetero atoms in the same ring;
and
Z is an aryl or heteroaryl group, a linear or branched C 1 -C 6 alkyl or alkenyl chain, a C 1 -C 4 alkyl-aryl group or a C 1 -C 4 alkyl-heteroaryl group.
in which:
G 1 and G 2 are hydrogen, halogen, hydroxyl, C 1 -C 4 alkoxy, C 1 -C 4 alkyl, and an amidino substituent of formula Q, provided that, for each compound of formula (I), only one of the two substituents G 1 or G 2 is an amidino substituent of formula Q:
and in which the substituents W, Y and X are combined to form 9- or 10-membered bicyclic heteroaromatic derivatives containing up to 2 hetero atoms in the same ring;
and
Z is an aryl or heteroaryl group, a linear or branched C 1 -C 6 alkyl or alkenyl chain, a C 1 -C 4 alkyl-aryl group or a C 1 -C 4 alkyl-heteroaryl group.
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