发明授权
EP1618092B1 ARYL-SUBSTITUTED PYRAZOLE-AMIDE COMPOUNDS USEFUL AS KINASE INHIBITORS
有权
作为激酶抑制剂的合适的芳PYRAZOLAMIDVERBINDUNGEN
- 专利标题： ARYL-SUBSTITUTED PYRAZOLE-AMIDE COMPOUNDS USEFUL AS KINASE INHIBITORS
- 专利标题（中）： 作为激酶抑制剂的合适的芳PYRAZOLAMIDVERBINDUNGEN
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申请号： EP04751133.2申请日： 2004-05-03
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公开(公告)号： EP1618092B1公开(公告)日： 2010-09-22
- 发明人: DYCKMAN, Alaric , DAS, Jagabandhu , LEFTHERIS, Katerina , LIU, Chunjian , ZHAO, Rulin , CHEN, Bang-Chi , WROBLESKI, Stephen, T.
- 申请人： Bristol-Myers Squibb Company
- 申请人地址： Route 206 and Province Line Road Princeton, NJ 08543-4000 US
- 专利权人： Bristol-Myers Squibb Company
- 当前专利权人： Bristol-Myers Squibb Company
- 当前专利权人地址： Route 206 and Province Line Road Princeton, NJ 08543-4000 US
- 代理机构： Beacham, Annabel Rose
- 优先权： US467029P 20030501
- 国际公布： WO2004099156 20041118
- 主分类号： C07D231/18
- IPC分类号： C07D231/18 ; A61K31/4155 ; A61P37/00
摘要：
The present invention relates to compounds having the formula (I), and pharmaceutically-acceptable salts, prodrugs, solvates, isomers, and/or hydrates thereof, wherein Q is an optionally-substituted phenyl, pyridyl, pyridazinyl, pyrimidinyl, or pyrazinyl ring; R2 is alkyl or an amino group as defined herein; and Z is optionally-substituted oxadiazolyl or -C(=O)NR6, wherein R6 is lower alkyl or cyclopropyl. The compounds are surprisingly advantageous in preparing medicaments for treating p38 kinase related conditions and/or in preparing medicaments for use in treating inflammatory disorders or conditions in a patient.
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