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公开(公告)号：EP2619190A1
公开(公告)日：2013-07-31
申请号：EP11764926.9
申请日：2011-09-23
发明人： DAS, Jagabandhu , KO, Soo Sung
IPC分类号： C07D271/06 , C07D413/04 , C07D413/10 , C07D417/04 , C07D417/12 , A61K31/4196 , A61P29/00 , A61P37/02
CPC分类号： C07D271/06 , C07D413/04 , C07D413/10 , C07D413/12 , C07D417/04 , C07D417/12
摘要： Disclosed are compounds of Formula (I): [PLEASE INSERT CHEMICAL STRUCTURE HERE] or stereoisomers, N-oxides, salts, or prodrugs thereof; wherein: Ring A is phenyl or 5- to 6-membered heteroaryl; (i) R1 and R2 are independently C1-C4 alkyl; or (ii) R1 and R2 together with the carbon atom to which they are attached, form a cyclic group; Q is phenyl or 5- to 6-membered heteroaryl substituted with zero to 3 substituents; and R3, L1, L2, and n are defined herein. Also disclosed are methods of using such compounds as selective agonists for G protein-coupled receptor S1P1, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as autoimmune diseases and vascular disease.
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公开(公告)号：EP2595969A1
公开(公告)日：2013-05-29
申请号：EP11736263.2
申请日：2011-07-20
IPC分类号： C07D271/06 , C07D413/10 , C07D413/14 , A61K31/4245 , A61P37/00 , A61P9/00
CPC分类号： C07D413/10 , A61K31/4245 , A61K31/4439 , A61K31/454 , C07D271/06 , C07D413/06 , C07D413/08 , C07D413/14 , C07D487/10
摘要： Disclosed are compounds of Formula (I): (I) or stereoisomers, salts, or prodrugs thereof, wherein: (i) R1 and R2 are independently C
1 -C
4 alkyl, or (ii) R
1 and R
2 together with the carbon atom to which they are attached, form a cyclic group; and Q is H, C
1-6 alkyl, phenyl or 5- to 6-membered heteroaryl substituted with zero to 3 substituents, and G is defined herein. Also disclosed are method of using such compounds as selective agonists for G protein-coupled receptor S1P1, and pharmaceutical compositions comprising such compounds. There compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as autoimmune diseases and chronic inflammatory disease.-
3.发明授权PYRAZOLO-PYRIMIDINE ANILINE COMPOUNDS USEFUL AS KINASE INHIBITORS 有权作为激酶抑制剂的吡唑并嘧啶SUITABLE PYRIMIDINANILINVERBINDUNGEN
公开(公告)号：EP1507780B1
公开(公告)日：2012-08-22
申请号：EP03731307.9
申请日：2003-05-16
IPC分类号： C07D487/04 , A61K31/519 , A61P11/06 , A61P17/06 , A61P19/10 , A61P19/02 , A61P37/06 , A61P3/10
CPC分类号： C07D487/04
摘要： Compounds having the formula (I), where all substituents are as defined herein, and pharmaceutically acceptable salts, prodrugs, and solvates thereof, are useful as kinase inhibitors.
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公开(公告)号：EP1620108A2
公开(公告)日：2006-02-01
申请号：EP04760705.6
申请日：2004-05-03
发明人： DYCKMAN, Alaric , DAS, Jagabandhu , LEFTHERIS, Katerina , LIU, Chunjian , MOQUIN, Robert, V. , WROBLESKI, Stephen, T.
IPC分类号： A61K31/535
CPC分类号： C07D231/14 , C07D231/12 , C07D231/40 , C07D401/12 , C07D413/12
摘要： The present invention provides pyrazole derived compounds of formula (I) useful for treating p38 kinase-associated conditions, where W, X, R1, R2, R3, R4, R5, R6 and m are as defined herein. The invention further pertains to pharmaceutical compositions containing at least one compound according to the invention useful for treating p38 kinase-associated conditions, and methods of inhibiting the activity of p38 kinase in a mammal.
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公开(公告)号：EP1610780A2
公开(公告)日：2006-01-04
申请号：EP04758053.5
申请日：2004-03-23
发明人： DAS, Jagabandhu , PADMANABHA, Ramesh , CHEN, Ping , NORRIS, Derek, J. , DOWEYKO, Arthur, M. P. , BARRISH, Joel , WITYAK, John , LOMBARDO, Louis, J. , LEE, Francis, Y. F.
IPC分类号： A61K31/427 , A61K31/506
CPC分类号： A61K31/427 , A61K31/506 , C07C237/40 , C07D213/81 , C07D213/82 , C07D231/38 , C07D233/90 , C07D239/42 , C07D263/48 , C07D277/56 , C07D409/12 , C07D417/12 , C07D417/14
摘要： Novel cyclic compounds and salts thereof, pharmaceutical compositions containing such compounds, and methods of using such compounds in the treatment of protein tyrosine kinase-associated disorders such as immunologic and oncologic disorders.
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公开(公告)号：EP2619190B1
公开(公告)日：2015-08-12
申请号：EP11764926.9
申请日：2011-09-23
发明人： DAS, Jagabandhu , KO, Soo Sung
IPC分类号： C07D271/06 , C07D413/04 , C07D413/10 , C07D417/04 , C07D417/12 , A61K31/4196 , A61P29/00 , A61P37/02
CPC分类号： C07D271/06 , C07D413/04 , C07D413/10 , C07D413/12 , C07D417/04 , C07D417/12
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公开(公告)号：EP2595969B1
公开(公告)日：2015-04-22
申请号：EP11736263.2
申请日：2011-07-20
IPC分类号： C07D413/06 , A61K31/4439 , A61K31/454 , C07D413/08 , C07D487/10
CPC分类号： C07D413/10 , A61K31/4245 , A61K31/4439 , A61K31/454 , C07D271/06 , C07D413/06 , C07D413/08 , C07D413/14 , C07D487/10
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公开(公告)号：EP1620108B1
公开(公告)日：2012-06-06
申请号：EP04760705.6
申请日：2004-05-03
发明人： DYCKMAN, Alaric , DAS, Jagabandhu , LEFTHERIS, Katerina , LIU, Chunjian , MOQUIN, Robert, V. , WROBLESKI, Stephen, T.
IPC分类号： C07D231/14 , A61K31/535 , A61P29/00 , C07D231/40 , C07D231/38
CPC分类号： C07D231/14 , C07D231/12 , C07D231/40 , C07D401/12 , C07D413/12
摘要： The present invention provides pyrazole derived compounds of formula (I) useful for treating p38 kinase-associated conditions, where W, X, R1, R2, R3, R4, R5, R6 and m are as defined herein. The invention further pertains to pharmaceutical compositions containing at least one compound according to the invention useful for treating p38 kinase-associated conditions, and methods of inhibiting the activity of p38 kinase in a mammal.
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9.发明授权ARYL-SUBSTITUTED PYRAZOLE-AMIDE COMPOUNDS USEFUL AS KINASE INHIBITORS 有权作为激酶抑制剂的合适的芳PYRAZOLAMIDVERBINDUNGEN
公开(公告)号：EP1618092B1
公开(公告)日：2010-09-22
申请号：EP04751133.2
申请日：2004-05-03
发明人： DYCKMAN, Alaric , DAS, Jagabandhu , LEFTHERIS, Katerina , LIU, Chunjian , ZHAO, Rulin , CHEN, Bang-Chi , WROBLESKI, Stephen, T.
IPC分类号： C07D231/18 , A61K31/4155 , A61P37/00
CPC分类号： C07D231/14 , C07D231/12 , C07D231/40 , C07D401/12 , C07D413/12
摘要： The present invention relates to compounds having the formula (I), and pharmaceutically-acceptable salts, prodrugs, solvates, isomers, and/or hydrates thereof, wherein Q is an optionally-substituted phenyl, pyridyl, pyridazinyl, pyrimidinyl, or pyrazinyl ring; R2 is alkyl or an amino group as defined herein; and Z is optionally-substituted oxadiazolyl or -C(=O)NR6, wherein R6 is lower alkyl or cyclopropyl. The compounds are surprisingly advantageous in preparing medicaments for treating p38 kinase related conditions and/or in preparing medicaments for use in treating inflammatory disorders or conditions in a patient.
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公开(公告)号：EP1610780B1
公开(公告)日：2010-04-21
申请号：EP04758053.5
申请日：2004-03-23
发明人： DAS, Jagabandhu , PADMANABHA, Ramesh , CHEN, Ping , NORRIS, Derek, J. , DOWEYKO, Arthur, M. P. , BARRISH, Joel , WITYAK, John , LOMBARDO, Louis, J. , LEE, Francis, Y. F.
IPC分类号： A61K31/427 , A61K31/506 , A61P35/02
CPC分类号： A61K31/427 , A61K31/506 , C07C237/40 , C07D213/81 , C07D213/82 , C07D231/38 , C07D233/90 , C07D239/42 , C07D263/48 , C07D277/56 , C07D409/12 , C07D417/12 , C07D417/14
摘要： Novel cyclic compounds and salts thereof, pharmaceutical compositions containing such compounds, and methods of using such compounds in the treatment of protein tyrosine kinase-associated disorders such as immunologic and oncologic disorders.
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