发明公开
EP1628535A2 CELL SPECIFIC REPLICATION-COMPETENT VIRAL VECTORS COMPRISING A SELF PROCESSING PEPTIDE CLEAVAGE SITE
审中-公开
具有自处理肽裂解POINT细胞特异性复制能力的病毒载体
- 专利标题： CELL SPECIFIC REPLICATION-COMPETENT VIRAL VECTORS COMPRISING A SELF PROCESSING PEPTIDE CLEAVAGE SITE
- 专利标题（中）： 具有自处理肽裂解POINT细胞特异性复制能力的病毒载体
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申请号： EP04754018.2申请日： 2004-06-02
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公开(公告)号： EP1628535A2公开(公告)日： 2006-03-01
- 发明人: KO, Derek , LI, Yuanhao , HARDING, Thomas , FANG, Jianmin , RAMESH, Nagarajan , YU, De Chao
- 申请人： CELL GENESYS, INC.
- 申请人地址： 500 Forbes Boulevard South San Francisco, CA 94080 US
- 专利权人： CELL GENESYS, INC.
- 当前专利权人： CELL GENESYS, INC.
- 当前专利权人地址： 500 Forbes Boulevard South San Francisco, CA 94080 US
- 代理机构： HOFFMANN EITLE
- 优先权： US475005P 20030603
- 国际公布： WO2004108893 20041216
- 主分类号： A01N63/00
- IPC分类号： A01N63/00 ; A61K48/00 ; C12N5/00 ; C12N15/00 ; C12N15/09 ; C12N15/63 ; C12N15/64 ; C12N15/66 ; C12N15/70 ; C12N15/74
摘要：
Cell specific replication-competent viral vectors comprising a self processing peptide cleavage sequence are provided. The targeted replication-competent viral vectors include two or more co-transcribed genes under transcriptional control of the same heterologous transcriptional regulatory element (TRE), wherein at least a second gene is under translational control of a self processing cleavage sequence or 2A sequence. Exemplary vector constructs may further include an additional proteolytic cleavage site which provides a means to remove the self processing peptide sequence from the viral vector.
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