专利检索 ap:("CELL GENESYS, INC.") AND inv:"RAMESH, Nagarajan" 第 1 页

1.

发明公开
METHODS AND REAGENTS FOR THE ENHANCEMENT OF VIRUS TRANSDUCTION IN THE BLADDER EPITHELIUM 审中-公开
标题翻译：方法和试剂增强病毒的传播在膀胱上皮

公开(公告)号：EP1583502A2

公开(公告)日：2005-10-12

申请号：EP03800237.4

申请日：2003-12-24

申请人： CELL GENESYS, INC.

发明人： RAMESH, Nagarajan , FREY, David , MEMARZADEH, Bahram , YU, DeChao

IPC分类号： A61K6/00

CPC分类号： A61K48/0083 , A61K9/0019 , A61K31/337 , A61K31/7024 , A61K35/761 , A61K45/06 , A61K47/10 , A61K47/26 , C12N7/00 , C12N2710/10332 , C12N2710/10343 , Y02A50/393 , Y02A50/465 , A61K2300/00 , A61K35/76

摘要： Agents and methods for enhancing recombinant virus transduction in the bladder epithelium are described. A first method involves contacting the luminal surface of the bladder with a composition comprising a transduction enhancing agent and an oncolytic virus. Alternatively, the luminal surface of the bladder can be contacted first with a pretreatment composition comprising a transduction enhancing agent and, subsequently, with a composition comprising an oncolytic virus. Bladder treatment compositions comprising a transduction enhancing agent and an oncolytic virus are also described.

2.

发明公开
CELL SPECIFIC REPLICATION-COMPETENT VIRAL VECTORS COMPRISING A SELF PROCESSING PEPTIDE CLEAVAGE SITE 审中-公开
标题翻译：具有自处理肽裂解POINT细胞特异性复制能力的病毒载体

公开(公告)号：EP1628535A2

公开(公告)日：2006-03-01

申请号：EP04754018.2

申请日：2004-06-02

申请人： CELL GENESYS, INC.

发明人： KO, Derek , LI, Yuanhao , HARDING, Thomas , FANG, Jianmin , RAMESH, Nagarajan , YU, De Chao

IPC分类号： A01N63/00 , A61K48/00 , C12N5/00 , C12N15/00 , C12N15/09 , C12N15/63 , C12N15/64 , C12N15/66 , C12N15/70 , C12N15/74

CPC分类号： C12N15/86 , A61K35/761 , A61K38/162 , A61K38/193 , C12N7/00 , C12N2710/10332 , C12N2710/10343 , C12N2770/32134 , C12N2830/008 , C12N2830/20 , A61K2300/00

摘要： Cell specific replication-competent viral vectors comprising a self processing peptide cleavage sequence are provided. The targeted replication-competent viral vectors include two or more co-transcribed genes under transcriptional control of the same heterologous transcriptional regulatory element (TRE), wherein at least a second gene is under translational control of a self processing cleavage sequence or 2A sequence. Exemplary vector constructs may further include an additional proteolytic cleavage site which provides a means to remove the self processing peptide sequence from the viral vector.