发明授权
EP1641758B1 DERIVES DE DIPHENYLPYRIDINE, LEUR PREPARATION ET LEUR APPLICATION THERAPEUTIQUE
有权
DIPHENYLPYRIDINDERIVATE及其制备和治疗用途
- 专利标题: DERIVES DE DIPHENYLPYRIDINE, LEUR PREPARATION ET LEUR APPLICATION THERAPEUTIQUE
- 专利标题(英): Diphenylpyridine derivatives, preparation and therapeutic application thereof
- 专利标题(中): DIPHENYLPYRIDINDERIVATE及其制备和治疗用途
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申请号: EP04767437.9申请日: 2004-06-24
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公开(公告)号: EP1641758B1公开(公告)日: 2008-10-29
- 发明人: BARTH, Francis , HORTALA, Laurent , RINALDI-CARMONA, Murielle
- 申请人: Sanofi-Aventis
- 申请人地址: 174, Avenue de France 75013 Paris FR
- 专利权人: Sanofi-Aventis
- 当前专利权人: Sanofi-Aventis
- 当前专利权人地址: 174, Avenue de France 75013 Paris FR
- 代理机构: Kugel, Dominique
- 优先权: FR0307757 20030626
- 国际公布: WO2005000817 20050106
- 主分类号: C07D213/55
- IPC分类号: C07D213/55 ; C07D213/56 ; C07D413/12 ; C07D401/12 ; C07D401/06 ; A61K31/4418
摘要:
The invention relates to 5,6-diphenylpyridine-3-carboxamide derivatives of general formula (I), where R1 = H, or (C1-C4) alkyl, R2 = a monoazo saturated heterocycle of 5 to 7 atoms, the nitrogen atom being substituted with a (C1 -C4)alkanoyl, NR10R11, a non-aromatic (C3-C10) carbocycle more than tri-substituted with (C1-C4) alkyl, a non-aromatic (C11-C12) carbocycle unsubstituted or mono- or poly-substituted with (C1-C4) alkyl, a monooxygenated saturated heterocycle with 5 to 7 atoms, more than tri-substituted with (C1-C4) alkyl, or R1 and R2, together with the nitrogen atom to which the above are bonded, form a 4-disubstituted piperidin-1-yl group, the salts, solvates and hydrates thereof. The invention further relates to a method for production and therapeutic application thereof.
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