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    DERIVES DE 1,5-DIARYLPYRROLE, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE
    1.
    发明公开
    DERIVES DE 1,5-DIARYLPYRROLE, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE 审中-公开
    1.5 DIARYLPYRROLDERIVATE，其制备方法及其在治疗中

    公开(公告)号：EP1853557A2

    公开(公告)日：2007-11-14

    申请号：EP06709331.0

    申请日：2006-02-16

    申请人： Sanofi-Aventis

    发明人： BARTH, Francis ,  CONGY, Christian ,  HORTALA, Laurent ,  RINALDI-CARMONA, Murielle

    IPC分类号： C07D207/32

    CPC分类号： C07D207/323 ,  C07D207/335 ,  C07D403/12

    摘要： The invention relates to compounds having formula (I), wherein: X represents a group having formula (II). According to the invention, R1 and R6 represent a hydrogen atom or an alkyl group. R2 represents a radical selected from among: a (C1-C12)alkyl; a non-aromatic carbocyclic radical at (C3-C12); a (C3-C7)cycloalkylmethyl; a phenyl, a benzyl, a benzhydryl, a benzhydrylmethyl, phenethyl, a benzodioxolyl, a dihydrobenzofuranyl, a dihydrobenzodioxinyl; a methyl substituted by a benzodioxolyl, a dihydrobenzofuranyl, a dihydrobenzodioxinyl; a non-substituted 1, 2, 3, 4-tetrahydronaphtalenyl; or a heterocyclic radical, an indolyl, a substituted or non-substituted benzothiazolyl, said radicals being substituted or non-substituted. R3 represents a (C1 -C5)alkyl or a (C3-C7) cycloalkyl. R4 and R5 represent a substituted or non-substituted phenyl. The invention also relates to a method of preparing said derivatives and to the application thereof in therapeutics.

    DERIVES DE DIPHENYLPYRIDINE, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE
    2.
    发明公开
    DERIVES DE DIPHENYLPYRIDINE, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE 有权
    DIPHENYLPYRIDINDERIVATE及其制备和治疗用途

    公开(公告)号：EP1641758A2

    公开(公告)日：2006-04-05

    申请号：EP04767437.9

    申请日：2004-06-24

    申请人： Sanofi-Aventis

    发明人： BARTH, Francis ,  HORTALA, Laurent ,  RINALDI-CARMONA, Murielle

    IPC分类号： C07D213/55 ,  C07D213/56 ,  C07D413/12 ,  C07D401/12 ,  C07D401/06 ,  A61K31/4418

    CPC分类号： C07D213/82 ,  C07D401/12 ,  C07D405/12

    摘要： The invention relates to 5,6-diphenylpyridine-3-carboxamide derivatives of general formula (I), where R1 = H, or (C1-C4) alkyl, R2 = a monoazo saturated heterocycle of 5 to 7 atoms, the nitrogen atom being substituted with a (C1 -C4)alkanoyl, NR10R11, a non-aromatic (C3-C10) carbocycle more than tri-substituted with (C1-C4) alkyl, a non-aromatic (C11-C12) carbocycle unsubstituted or mono- or poly-substituted with (C1-C4) alkyl, a monooxygenated saturated heterocycle with 5 to 7 atoms, more than tri-substituted with (C1-C4) alkyl, or R1 and R2, together with the nitrogen atom to which the above are bonded, form a 4-disubstituted piperidin-1-yl group, the salts, solvates and hydrates thereof. The invention further relates to a method for production and therapeutic application thereof.

    DERIVES DE 4,5-DIARYLPYRROLE, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE
    5.
    发明公开
    DERIVES DE 4,5-DIARYLPYRROLE, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE 有权
    4,5- diarylpyrrole，用于在治疗PRODUCING和使用它们的衍生物

    公开(公告)号：EP1899298A2

    公开(公告)日：2008-03-19

    申请号：EP06764809.7

    申请日：2006-06-22

    申请人： Sanofi-Aventis

    发明人： BARTH, Francis ,  CONGY, Christian ,  HORTALA, Laurent ,  RINALDI-CARMONA, Murielle

    IPC分类号： C07D207/32 ,  A61K31/40

    CPC分类号： C07D207/335 ,  C07D207/323

    摘要： The invention relates to compounds having formula (I), wherein: X represents a group (II); R1 represents a hydrogen atom or a (C1-C4)alkyl group; R2 represents a (C1-C12)alkyl group, a non-aromatic carbocyclic radical at (C3-C12) which may or may not be substituted, a methyl which is substituted by a non-aromatic carbocyclic radical at (C3-C12) which may or may not be substituted, a phenyl, benzyl, benzhydryl radical which may or may not be substituted, a substituted or non-substituted heterocyclic radical, a methyl substituted by a non-aromatic carbocyclic radical at (C3-C12) which may or may not be substituted; R3 represents a (C1-C5)alkyl or a (C3-C7) cycloalkyl; R4 represents a substituted or non-substituted phenyl; and R5 represents a substituted or non-substituted phenyl. The invention also relates to the preparation method thereof and the use of same in therapeutics.

    DERIVES DE DIPHENYLPYRIDINE, LEUR PREPARATION ET LEUR APPLICATION THERAPEUTIQUE
    7.
    发明授权
    DERIVES DE DIPHENYLPYRIDINE, LEUR PREPARATION ET LEUR APPLICATION THERAPEUTIQUE 有权
    DIPHENYLPYRIDINDERIVATE及其制备和治疗用途

    公开(公告)号：EP1641758B1

    公开(公告)日：2008-10-29

    申请号：EP04767437.9

    申请日：2004-06-24

    申请人： Sanofi-Aventis

    发明人： BARTH, Francis ,  HORTALA, Laurent ,  RINALDI-CARMONA, Murielle

    IPC分类号： C07D213/55 ,  C07D213/56 ,  C07D413/12 ,  C07D401/12 ,  C07D401/06 ,  A61K31/4418

    CPC分类号： C07D213/82 ,  C07D401/12 ,  C07D405/12

    摘要： The invention relates to 5,6-diphenylpyridine-3-carboxamide derivatives of general formula (I), where R1 = H, or (C1-C4) alkyl, R2 = a monoazo saturated heterocycle of 5 to 7 atoms, the nitrogen atom being substituted with a (C1 -C4)alkanoyl, NR10R11, a non-aromatic (C3-C10) carbocycle more than tri-substituted with (C1-C4) alkyl, a non-aromatic (C11-C12) carbocycle unsubstituted or mono- or poly-substituted with (C1-C4) alkyl, a monooxygenated saturated heterocycle with 5 to 7 atoms, more than tri-substituted with (C1-C4) alkyl, or R1 and R2, together with the nitrogen atom to which the above are bonded, form a 4-disubstituted piperidin-1-yl group, the salts, solvates and hydrates thereof. The invention further relates to a method for production and therapeutic application thereof.