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39 条记录 (耗时 0.021 秒)

    DERIVES DE N-[(4,5-DIPHENYLPYRIMIDIN-2-YL)METHYL]AMINE, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE
    4.
    发明授权
    DERIVES DE N-[(4,5-DIPHENYLPYRIMIDIN-2-YL)METHYL]AMINE, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE 有权
    N - [（4,5-二苯基-2-基）甲基] AMIN衍生物，其制备及其用途THERAPEUTIC

    公开(公告)号：EP1937672B1

    公开(公告)日：2009-09-02

    申请号：EP06778797.8

    申请日：2006-07-06

    申请人： Sanofi-Aventis

    发明人： BARTH, Francis ,  CONGY, Christian ,  GUEULE, Patrick ,  RINALDI-CARMONA, Murielle

    IPC分类号： C07D409/12 ,  C07D405/12 ,  C07D403/12 ,  C07D239/26 ,  A61K31/506 ,  A61P25/00 ,  A61P3/00 ,  A61P1/00

    CPC分类号： C07D405/12 ,  C07D239/26 ,  C07D403/12 ,  C07D409/12

    摘要： The invention relates to compounds of formula (I) in which: X represents a group (a); R1 represents an unsubstituted or substituted C1-C12 alkyl; an unsubstituted or substituted non-aromatic C3-C12 carbocyclic radical; an unsubstituted or substituted C3-C7 cycloalkylmethyl; an unsubstituted or substituted phenyl; an unsubstituted or substituted benzyl; an unsubstituted or substituted phenethyl; a benzhydryl; a benzhydryl methyl; an unsubstituted or substituted 1,2,3,4-tetrahydronaphtalenyl; an aromatic heterocyclic radical; R2 represents a hydrogen atom or a C1-C3 alkyl; R3 represents a hydrogen atom or a C1-C5 alkyl; R4 represents an unsubstituted or substituted phenyl; R5 represents an unsubstituted or substituted phenyl; R6 represents a hydrogen atom or a C1-C3 alkyl; n represents 0, 1 or 2; Alk represents an unsubstituted or substituted C1-C4 alkyl; with the condition that R4 and R5 do not simultaneously represent a phenyl substituted by a C1-C4 alkoxy. The invention also relates to a method for preparing the aforementioned compounds and to their therapeutic use.

    DERIVES DE DIPHENYLPYRIDINE, LEUR PREPARATION ET LEUR APPLICATION THERAPEUTIQUE
    5.
    发明授权
    DERIVES DE DIPHENYLPYRIDINE, LEUR PREPARATION ET LEUR APPLICATION THERAPEUTIQUE 有权
    DIPHENYLPYRIDINDERIVATE及其制备和治疗用途

    公开(公告)号：EP1641758B1

    公开(公告)日：2008-10-29

    申请号：EP04767437.9

    申请日：2004-06-24

    申请人： Sanofi-Aventis

    发明人： BARTH, Francis ,  HORTALA, Laurent ,  RINALDI-CARMONA, Murielle

    IPC分类号： C07D213/55 ,  C07D213/56 ,  C07D413/12 ,  C07D401/12 ,  C07D401/06 ,  A61K31/4418

    CPC分类号： C07D213/82 ,  C07D401/12 ,  C07D405/12

    摘要： The invention relates to 5,6-diphenylpyridine-3-carboxamide derivatives of general formula (I), where R1 = H, or (C1-C4) alkyl, R2 = a monoazo saturated heterocycle of 5 to 7 atoms, the nitrogen atom being substituted with a (C1 -C4)alkanoyl, NR10R11, a non-aromatic (C3-C10) carbocycle more than tri-substituted with (C1-C4) alkyl, a non-aromatic (C11-C12) carbocycle unsubstituted or mono- or poly-substituted with (C1-C4) alkyl, a monooxygenated saturated heterocycle with 5 to 7 atoms, more than tri-substituted with (C1-C4) alkyl, or R1 and R2, together with the nitrogen atom to which the above are bonded, form a 4-disubstituted piperidin-1-yl group, the salts, solvates and hydrates thereof. The invention further relates to a method for production and therapeutic application thereof.

    DERIVES HETEROCYCLIQUES, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE.
    7.
    发明授权
    DERIVES HETEROCYCLIQUES, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE. 有权
    杂环衍生物，生产和治疗的使用

    公开(公告)号：EP1966173B1

    公开(公告)日：2010-11-17

    申请号：EP06841900.1

    申请日：2006-12-11

    申请人： Sanofi-Aventis

    发明人： BARTH, Francis ,  RINALDI-CARMONA, Murielle

    IPC分类号： C07D277/28

    CPC分类号： C07D417/12 ,  C07D263/32 ,  C07D277/28

    摘要： The invention concerns compounds of formula (I) wherein: X represents a -C-, -SO2-, -C-N(R5)-C-N(R5)- group; Y represents an oxygen atom or a sulphur atom; R1 represents a hydrogen atom or a C1-C4 alkyl group; R2 represents a C1-C7 alkyl group, a carbocyclic radical, a methyl substituted by a C3-C12 non aromatic carbocyclic radical, a phenyl, a phenoxymethyl, a benzyl, a benzhydryl, a benzhydrylmethyl group, a 1,2,3,4-tetrahydronaphthalenyl, a pyrrolyl, imidazolyl, pyridyl, pyrazolyl, furyl, thienyl radical; an indolyl; a benzofuryl; R3 represents a substituted or unsubstituted phenyl; R4 represents a substituted or unsubstituted phenyl; R5 represents a hydrogen atom or a C1-C4 alkyl; as well as their salts and solvates. The invention also concerns a method for preparing same and the therapeutic use thereof.

    DERIVES HETEROCYCLIQUES, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE.
    8.
    发明公开
    DERIVES HETEROCYCLIQUES, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE. 有权
    杂环衍生物，生产和治疗的使用

    公开(公告)号：EP1966173A2

    公开(公告)日：2008-09-10

    申请号：EP06841900.1

    申请日：2006-12-11

    申请人： Sanofi-Aventis

    发明人： BARTH, Francis ,  RINALDI-CARMONA, Murielle

    IPC分类号： C07D277/28

    CPC分类号： C07D417/12 ,  C07D263/32 ,  C07D277/28

    摘要： The invention concerns compounds of formula (I) wherein: X represents a -C-, -SO2-, -C-N(R5)-C-N(R5)- group; Y represents an oxygen atom or a sulphur atom; R1 represents a hydrogen atom or a C1-C4 alkyl group; R2 represents a C1-C7 alkyl group, a carbocyclic radical, a methyl substituted by a C3-C12 non aromatic carbocyclic radical, a phenyl, a phenoxymethyl, a benzyl, a benzhydryl, a benzhydrylmethyl group, a 1,2,3,4-tetrahydronaphthalenyl, a pyrrolyl, imidazolyl, pyridyl, pyrazolyl, furyl, thienyl radical; an indolyl; a benzofuryl; R3 represents a substituted or unsubstituted phenyl; R4 represents a substituted or unsubstituted phenyl; R5 represents a hydrogen atom or a C1-C4 alkyl; as well as their salts and solvates. The invention also concerns a method for preparing same and the therapeutic use thereof.

    DERIVES D'OXAZOLE, LEUR PREPARATION ET LEUR UTILISATION EN THERAPEUTIQUE
    10.
    发明公开
    DERIVES D'OXAZOLE, LEUR PREPARATION ET LEUR UTILISATION EN THERAPEUTIQUE 审中-公开
    恶唑及其制备和治疗用途

    公开(公告)号：EP1716142A2

    公开(公告)日：2006-11-02

    申请号：EP05717611.7

    申请日：2005-02-11

    申请人： Sanofi-Aventis

    发明人： ARNAUD-TAILLADES, Joëlle ,  BARTH, Francis ,  CONGY, Christian ,  RINALDI-CARMONA, Murielle

    IPC分类号： C07D413/06 ,  C07D491/10 ,  C07D263/34

    CPC分类号： C07D263/34 ,  C07D413/06 ,  C07D491/10

    摘要： The invention relates to compounds of formula (I) where R1 = H or C1-C4 alkyl, R2 = C4-C10 alkyl, a C3-C12 non-aromatic carbocyclic group, a 1,2,3,4-tetrahydronaphthalenyl, a heterocyclic group, a C1-C3 alkylene group with a carbocyclic group, a phenylalkylene group, a NR9R10 group, or R1 and R2, together with the nitrogen atom to which they are bonded, are either a piperazin-1-yl or 1,4-diazepan-1-yl, or a piperidin-1-yl or pyrrolidin-1-yl, R3, R4, R5, R6, R7, R8 independently = H or halogen, a C1-C6 alkyl, C1-C6 alkoxy, trifluoromethyl or S(O)nAlk group in the form of a base or acid addition salts and in the hydrated or solvated state. The invention further relates to a method for preparation and therapeutic use thereof.