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    DERIVES DE N-[(4,5-DIPHENYLPYRIMIDIN-2-YL)METHYL]AMINE, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE
    4.
    发明授权
    DERIVES DE N-[(4,5-DIPHENYLPYRIMIDIN-2-YL)METHYL]AMINE, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE 有权
    N - [（4,5-二苯基-2-基）甲基] AMIN衍生物，其制备及其用途THERAPEUTIC

    公开(公告)号：EP1937672B1

    公开(公告)日：2009-09-02

    申请号：EP06778797.8

    申请日：2006-07-06

    申请人： Sanofi-Aventis

    发明人： BARTH, Francis ,  CONGY, Christian ,  GUEULE, Patrick ,  RINALDI-CARMONA, Murielle

    IPC分类号： C07D409/12 ,  C07D405/12 ,  C07D403/12 ,  C07D239/26 ,  A61K31/506 ,  A61P25/00 ,  A61P3/00 ,  A61P1/00

    CPC分类号： C07D405/12 ,  C07D239/26 ,  C07D403/12 ,  C07D409/12

    摘要： The invention relates to compounds of formula (I) in which: X represents a group (a); R1 represents an unsubstituted or substituted C1-C12 alkyl; an unsubstituted or substituted non-aromatic C3-C12 carbocyclic radical; an unsubstituted or substituted C3-C7 cycloalkylmethyl; an unsubstituted or substituted phenyl; an unsubstituted or substituted benzyl; an unsubstituted or substituted phenethyl; a benzhydryl; a benzhydryl methyl; an unsubstituted or substituted 1,2,3,4-tetrahydronaphtalenyl; an aromatic heterocyclic radical; R2 represents a hydrogen atom or a C1-C3 alkyl; R3 represents a hydrogen atom or a C1-C5 alkyl; R4 represents an unsubstituted or substituted phenyl; R5 represents an unsubstituted or substituted phenyl; R6 represents a hydrogen atom or a C1-C3 alkyl; n represents 0, 1 or 2; Alk represents an unsubstituted or substituted C1-C4 alkyl; with the condition that R4 and R5 do not simultaneously represent a phenyl substituted by a C1-C4 alkoxy. The invention also relates to a method for preparing the aforementioned compounds and to their therapeutic use.

    DERIVES DE DIPHENYLPYRIDINE, LEUR PREPARATION ET LEUR APPLICATION THERAPEUTIQUE
    5.
    发明授权
    DERIVES DE DIPHENYLPYRIDINE, LEUR PREPARATION ET LEUR APPLICATION THERAPEUTIQUE 有权
    DIPHENYLPYRIDINDERIVATE及其制备和治疗用途

    公开(公告)号：EP1641758B1

    公开(公告)日：2008-10-29

    申请号：EP04767437.9

    申请日：2004-06-24

    申请人： Sanofi-Aventis

    发明人： BARTH, Francis ,  HORTALA, Laurent ,  RINALDI-CARMONA, Murielle

    IPC分类号： C07D213/55 ,  C07D213/56 ,  C07D413/12 ,  C07D401/12 ,  C07D401/06 ,  A61K31/4418

    CPC分类号： C07D213/82 ,  C07D401/12 ,  C07D405/12

    摘要： The invention relates to 5,6-diphenylpyridine-3-carboxamide derivatives of general formula (I), where R1 = H, or (C1-C4) alkyl, R2 = a monoazo saturated heterocycle of 5 to 7 atoms, the nitrogen atom being substituted with a (C1 -C4)alkanoyl, NR10R11, a non-aromatic (C3-C10) carbocycle more than tri-substituted with (C1-C4) alkyl, a non-aromatic (C11-C12) carbocycle unsubstituted or mono- or poly-substituted with (C1-C4) alkyl, a monooxygenated saturated heterocycle with 5 to 7 atoms, more than tri-substituted with (C1-C4) alkyl, or R1 and R2, together with the nitrogen atom to which the above are bonded, form a 4-disubstituted piperidin-1-yl group, the salts, solvates and hydrates thereof. The invention further relates to a method for production and therapeutic application thereof.

    DERIVES DIARYLTRIAZOLMETHYLAMINE, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE.
    8.
    发明授权
    DERIVES DIARYLTRIAZOLMETHYLAMINE, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE. 有权
    DIARYLTRIAZOLMETHYLAMIN衍生物及其制备及其治疗用途

    公开(公告)号：EP1966167B1

    公开(公告)日：2010-06-16

    申请号：EP06841899.5

    申请日：2006-12-11

    申请人： sanofi-aventis

    发明人： BARTH, Francis ,  RINALDI-CARMONA, Murielle

    IPC分类号： C07D249/08 ,  C07D401/12 ,  C07D405/12 ,  C07D413/12

    CPC分类号： C07D405/12 ,  C07D249/08 ,  C07D403/12 ,  C07D409/12 ,  C07D413/12

    摘要： The invention concerns compounds of formula (I) wherein: X represents a group formula (II); R1 represents a hydrogen atom or a C1-C4 alkyl group; R2 represents a substituted our unsubstituted C1-C7 alkyl group, a carbocyclic group, a methyl substituted by a non aromatic C3-C12 carbocyclic radical, a phenyl, a phenoxymethyl, a benzyl, a benzhydryl, a benzhydrylmethyl group, a 1,2,3,4-tetrahydronaphthalenyl, a pyrrolyl, imidazolyl, pyridyl, pyrazolyl, ruryl, thienyl radical, an indolyl, a benzofuryl, a 2,1,3-benzoxadiazolyl; R3 represents a substituted or unsubstituted phenyl; R4 represents a substituted or unsubstituted phenyl; R5 represents a hydrogen atom or a C1-C4 alkyl; their salts and solvates. The invention also concerns a method for preparing same and the therapeutic use thereof.

    DERIVES DE N-'(1,5-DIPHENYL-1H-PYRAZOL-3-YL)METHYL SULFONAMIDE AVEC UNE AFFINITE POUR LES RECEPTEURS CB1
    9.
    发明授权
    DERIVES DE N-'(1,5-DIPHENYL-1H-PYRAZOL-3-YL)METHYL SULFONAMIDE AVEC UNE AFFINITE POUR LES RECEPTEURS CB1 有权
    N“ - （1,5-二苯基-1H-吡唑-3-基），其具有亲和力的CB 1受体磺酰胺衍生物

    公开(公告)号：EP1720837B1

    公开(公告)日：2010-04-28

    申请号：EP05717379.1

    申请日：2005-01-07

    申请人： Sanofi-Aventis

    发明人： BARTH, Francis ,  CONGY, Christian ,  MARTINEZ, Serge ,  RINALDI-CARMONA, Murielle

    IPC分类号： C07D231/12 ,  A61K31/415 ,  A61P25/00 ,  C07D409/12 ,  C07D413/14

    CPC分类号： C07D231/12 ,  C07D409/12 ,  C07D413/14

    摘要： The invention relates to compounds having formula (I), the preparation method thereof and the use of same in therapeutics, wherein: R1 represents a (C1-C6)alkyl, a (C3-C7)cycloalkyl which is unsubstituted or is mono- or poly-substituted, a (C3-C7)cycloalkylmethyl which is unsubstituted or is mono- or poly-substituted, a phenyl which is unsubstituted or substituted; a benzyl which is unsubstituted or is mono- or disubstituted, a thienyl which is unsubstituted or substituted; R2 represents a hydrogen atom or a (C1-C3)alkyl; R3 represents a hydrogen atom or a (C1-C5)alkyl; R4, R5, R6, R7, R8 and R9 each represent, independently of each other, a hydrogen atom, a halogen atom, a (C1-C7)alkyl, a (C1-C5)alkoxy, a trifluoromethyl radical or a S(O)nAlk group; n represents 0, 1 or 2; and Alk represents a (C1-C4)alkyl. The invention also relates to the preparation method thereof and to the use of same in therapeutics.

    DERIVES DIARYLTRIAZOLMETHYLAMINE, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE.
    10.
    发明公开
    DERIVES DIARYLTRIAZOLMETHYLAMINE, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE. 有权
    DIARYLTRIAZOLMETHYLAMIN衍生物及其制备及其治疗用途

    公开(公告)号：EP1966167A1

    公开(公告)日：2008-09-10

    申请号：EP06841899.5

    申请日：2006-12-11

    申请人： sanofi-aventis

    发明人： BARTH, Francis ,  RINALDI-CARMONA, Murielle

    IPC分类号： C07D249/08 ,  C07D401/12 ,  C07D405/12 ,  C07D413/12

    CPC分类号： C07D405/12 ,  C07D249/08 ,  C07D403/12 ,  C07D409/12 ,  C07D413/12

    摘要： The invention concerns compounds of formula (I) wherein: X represents a group formula (II); R1 represents a hydrogen atom or a C1-C4 alkyl group; R2 represents a substituted our unsubstituted C1-C7 alkyl group, a carbocyclic group, a methyl substituted by a non aromatic C3-C12 carbocyclic radical, a phenyl, a phenoxymethyl, a benzyl, a benzhydryl, a benzhydrylmethyl group, a 1,2,3,4-tetrahydronaphthalenyl, a pyrrolyl, imidazolyl, pyridyl, pyrazolyl, ruryl, thienyl radical, an indolyl, a benzofuryl, a 2,1,3-benzoxadiazolyl; R3 represents a substituted or unsubstituted phenyl; R4 represents a substituted or unsubstituted phenyl; R5 represents a hydrogen atom or a C1-C4 alkyl; their salts and solvates. The invention also concerns a method for preparing same and the therapeutic use thereof.