发明公开
- 专利标题： THIAZOLINE DERIVATIVE AND USE OF THE SAME
- 专利标题（中）： THIAZOLINDERIVAT UND DESSEN VERWENDUNG
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申请号： EP04773616.0申请日： 2004-09-29
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公开(公告)号： EP1669352A1公开(公告)日： 2006-06-14
- 发明人: KUBO, Keiji Takeda Pharmaceutical Company Limited , KUROITA, Takanobu Takeda Pharmaceutical Comp. Ltd. , KAWAMURA, Masaki Takeda Pharmaceutcal Comp. Ltd. , SAKAMOTO, Hiroki Takada Pharmaceutical Comp. Ltd.
- 申请人： Takeda Pharmaceutical Company Limited
- 申请人地址： 1-1, Doshomachi 4-chome Chuo-ku Osaka-shi, Osaka 541-0045 JP
- 专利权人： Takeda Pharmaceutical Company Limited
- 当前专利权人： Takeda Pharmaceutical Company Limited
- 当前专利权人地址： 1-1, Doshomachi 4-chome Chuo-ku Osaka-shi, Osaka 541-0045 JP
- 代理机构： Lewin, John Harvey
- 优先权： JP2003341430 20030930
- 国际公布： WO2005030740 20050407
- 主分类号： C07D277/42
- IPC分类号： C07D277/42 ; C07D513/04 ; C07D417/12 ; C07D417/04 ; C07D417/06 ; C07D417/14 ; A61K31/496 ; A61K31/427 ; A61K31/497 ; A61P43/00 ; A61P7/02 ; A61P9/10 ; A61P25/28
摘要：
A thiazoline derivative represented by Formula (I):
wherein R is a cyclic hydrocarbon group which may be substituted, or a heterocyclic group which may be substituted; X is a bond or a divalent chain hydrocarbon group which may be substituted; X' is a bond or -N(R 5 )-; Y is a divalent hydrocarbon group which may be substituted; Y' is a bond or -C(=O)-; ring A is a nitrogen-containing heterocycle which may be substituted; Z 1 and Z 3 are each independently a bond or a divalent chain hydrocarbon group which may be substituted; Z 2 is a bond or -N(R 6 )-; and B is a group represented by the formula:
which is useful as a therapeutic drug for thrombosis, is provided.
wherein R is a cyclic hydrocarbon group which may be substituted, or a heterocyclic group which may be substituted; X is a bond or a divalent chain hydrocarbon group which may be substituted; X' is a bond or -N(R 5 )-; Y is a divalent hydrocarbon group which may be substituted; Y' is a bond or -C(=O)-; ring A is a nitrogen-containing heterocycle which may be substituted; Z 1 and Z 3 are each independently a bond or a divalent chain hydrocarbon group which may be substituted; Z 2 is a bond or -N(R 6 )-; and B is a group represented by the formula:
which is useful as a therapeutic drug for thrombosis, is provided.
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