发明公开
- 专利标题： UREA DERIVATIVE, PROCESS FOR PRODUCING THE SAME, AND USE
- 专利标题（中）： 尿素衍生物，生产方法和用途
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申请号： EP04807076.7申请日： 2004-12-15
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公开(公告)号： EP1695961A1公开(公告)日： 2006-08-30
- 发明人: KUBO, Keiji c/o Takeda Pharma Co., Ltd. , IMAEDA, Yasuhiro c/oTakeda Pharma Co., Ltd,
- 申请人： Takeda Pharmaceutical Company Limited
- 申请人地址： 1-1, Doshomachi 4-chome Chuo-ku Osaka-shi, Osaka 541-0045 JP
- 专利权人： Takeda Pharmaceutical Company Limited
- 当前专利权人： Takeda Pharmaceutical Company Limited
- 当前专利权人地址： 1-1, Doshomachi 4-chome Chuo-ku Osaka-shi, Osaka 541-0045 JP
- 代理机构： Wright, Robert Gordon McRae
- 优先权： JP2003420031 20031217
- 国际公布： WO2005058823 20050630
- 主分类号： C07D211/58
- IPC分类号： C07D211/58 ; C07D211/76 ; C07D277/42 ; C07D471/04 ; C07D487/04 ; C07D213/74 ; C07D417/04 ; C07D401/04 ; C07D413/04 ; C07D417/06 ; C07D417/12 ; A61K31/4545 ; A61K31/454 ; A61K31/5377 ; A61K31/496 ; A61K31/427 ; A61P7/02 ; A61P9/10
摘要：
The present invention provides a urea derivative or a salt thereof, which is useful as a therapeutic agent for thrombosis. The derivative is represented by Formula (I):
[Chemical formula I]
wherein Cy is an aromatic hydrocarbon group which may be substituted or an aromatic heterocyclic group which may be substituted; R 1 is a hydrogen atom or a hydrocarbon group which may be substituted; V is -C(O)-, -S(O)-, or -S(O) 2 -; W is -N(R 2 )-, -O-, or a bond (wherein R 2 is a hydrogen atom or a hydrocarbon group which may be substituted); X is alkylene which may be substituted; Y is -C(O)-, -S(O)-, or -S(O) 2 -; Z is a bond, a chain hydrocarbon group which may be substituted, or -N=; ring A is a non-aromatic nitrogen-containing heterocyclic ring which may be substituted; ring B is a nitrogen-containing heterocyclic ring which may be substituted; and
[Chemical formula 2]
- - - - - - ‾ , - - - - - - ̲
are each independently a single bond or a double bond; provided that R 1 may be bonded to R 2 to form a non-aromatic nitrogen-containing heterocyclic ring and that R 2 may be bonded to a substituent of X to form a non-aromatic nitrogen-containing heterocyclic ring which may be substituted.
[Chemical formula I]
wherein Cy is an aromatic hydrocarbon group which may be substituted or an aromatic heterocyclic group which may be substituted; R 1 is a hydrogen atom or a hydrocarbon group which may be substituted; V is -C(O)-, -S(O)-, or -S(O) 2 -; W is -N(R 2 )-, -O-, or a bond (wherein R 2 is a hydrogen atom or a hydrocarbon group which may be substituted); X is alkylene which may be substituted; Y is -C(O)-, -S(O)-, or -S(O) 2 -; Z is a bond, a chain hydrocarbon group which may be substituted, or -N=; ring A is a non-aromatic nitrogen-containing heterocyclic ring which may be substituted; ring B is a nitrogen-containing heterocyclic ring which may be substituted; and
[Chemical formula 2]
- - - - - - ‾ , - - - - - - ̲
are each independently a single bond or a double bond; provided that R 1 may be bonded to R 2 to form a non-aromatic nitrogen-containing heterocyclic ring and that R 2 may be bonded to a substituent of X to form a non-aromatic nitrogen-containing heterocyclic ring which may be substituted.
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