发明公开
- 专利标题： PREVENTIVE AND/OR THERAPEUTIC AGENT FOR DISEASE IN WHICH MITOCHONDRIAL BENZODIAZEPINE RECEPTOR PARTICIPATES
- 专利标题（中）： 预防和/或治疗剂疾病涉及线粒体苯二氮受体
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申请号： EP04808103申请日： 2004-12-24
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公开(公告)号： EP1698335A4公开(公告)日： 2007-08-01
- 发明人: OHMOTO K , KATO MASASHI , KATSUMATA S , MANAKO J
- 申请人： ONO PHARMACEUTICAL CO
- 专利权人： ONO PHARMACEUTICAL CO
- 当前专利权人： ONO PHARMACEUTICAL CO
- 优先权： JP2003433417 2003-12-26
- 主分类号： A61K31/415
- IPC分类号： A61K31/415 ; A61K31/4155 ; A61K31/416 ; A61K31/4162 ; A61K31/4164 ; A61K31/417 ; A61K31/4172 ; A61K31/4184 ; A61K31/496 ; A61K45/00 ; A61K45/06 ; A61P1/04 ; A61P9/06 ; A61P9/12 ; A61P11/02 ; A61P11/06 ; A61P13/00 ; A61P15/00 ; A61P15/10 ; A61P15/12 ; A61P25/00 ; A61P25/08 ; A61P25/16 ; A61P25/20 ; A61P25/22 ; A61P25/24 ; A61P25/28 ; A61P43/00 ; C07D231/38 ; C07D231/56 ; C07D233/54 ; C07D233/64 ; C07D409/12 ; C07D487/04 ; C07D495/04
摘要：
A compound represented by the general formula (I): (I) (wherein ring A represents an optionally substituted nitrogenous ring; E represents a bond or a spacer having a C1-8 main chain; and Q represents hydrogen, an optionally substituted hydrocarbon group, or an optionally substituted cyclic group), a salt, N-oxide, or solvate of the compound, or a prodrug of any of these. The compound represented by the general formula (I), salt, N-oxide, solvate, and prodrug have an affinity for MBR and are hence useful as a preventive and/or therapeutic agent for diseases attributable to stresses.
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