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公开(公告)号：EP1679309A4
公开(公告)日：2007-03-28
申请号：EP04793164
申请日：2004-10-22
IPC分类号： A61K31/505 , A61K31/506 , A61K31/517 , A61P25/00 , C07D239/42 , C07D409/12
CPC分类号： C07D409/12 , A61K31/505 , A61K31/506 , A61K31/517 , C07D239/42
摘要： A compound of the general formula: (I) (wherein the ring A represents a substituted or unsubstituted cyclic group; Q a substituted or unsubstituted alkyl or a substituted or unsubstituted cyclic group; the ring D a substituted or unsubstituted cyclic group; W a bond or a spacer with a principal chain of 1 to 4 atoms; and Y a spacer with a principal chain of 1 to 4 atoms), or its salt, N-oxide or solvate, or a prodrug thereof. The compound of the general formula (I), or its salt, N-oxide or solvate, or a prodrug thereof has affinity with MBR, thereby being useful as a preventive and/or curative drug for diseases caused by stress.
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2.发明公开AMINO ACID DERIVATIVES AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT 审中-公开氨基酸衍生物和药物，如活性成分含
公开(公告)号：EP1097929A4
公开(公告)日：2005-12-21
申请号：EP99929813
申请日：1999-07-13
发明人： SEKO TAKUYA , KATO MASASHI
IPC分类号： C07D277/06 , C07D401/12 , C07D417/06 , C07D417/12 , C07D417/14 , C07D277/04 , A61K31/425 , A61K31/44 , A61K31/445 , A61K31/535 , A61K38/05 , C07K5/078
CPC分类号： C07D417/12 , C07D277/06 , C07D417/06 , C07D417/14
摘要： Compounds represented by general formula (I) and salts thereof, wherein each symbol is as defined in the specification. The compounds of general formula (I) inhibit the N-type calcium channel, which makes them useful as preventives and/or remedies for brain infraction, transient cerebral ischemic attack, postoperative cerebrospinal failure, spinal vascular failure, stress hypertension, neurosis, epilepsy, asthma, frequent urination, etc. or remedies for pain.
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公开(公告)号：EP1829874A4
公开(公告)日：2010-01-06
申请号：EP05820106
申请日：2005-12-21
IPC分类号： C07D471/04 , A61K31/437 , A61K31/4375 , A61P1/00 , A61P1/04 , A61P1/12
CPC分类号： C07D471/14 , A61K31/4375 , A61K31/438 , A61K45/06 , C07D471/04 , C07D471/10
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4.发明公开AMINO ACID DERIVATIVES AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT 审中-公开AMINOSÄUREDERIVATEUND MEDIKAMENTE DIE DIESE ALS WIRKSTOFF ENTHALTEN
公开(公告)号：EP1090912A4
公开(公告)日：2010-01-06
申请号：EP99928205
申请日：1999-06-25
发明人： SEKO TAKUYA , KATO MASASHI
IPC分类号： A61K31/445 , A61K38/00 , A61P9/00 , C07C323/60 , C07D207/14 , C07D211/26 , C07D211/58 , C07D213/74 , C07D277/06 , C07D295/135 , C07D295/185 , C07D409/12 , C07D417/12 , C07K5/06 , C07K5/078 , A61K31/165 , A61K31/425 , A61K31/495 , A61K31/535 , C07D295/12 , C07D295/18
CPC分类号： C07D213/74 , A61K38/00 , C07B2200/07 , C07C323/60 , C07C2601/14 , C07D211/26 , C07D211/58 , C07D277/06 , C07D295/135 , C07D295/185 , C07D409/12 , C07D417/12 , C07K5/06139 , C07K5/06191
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公开(公告)号：EP1637521A4
公开(公告)日：2009-08-26
申请号：EP04746540
申请日：2004-06-22
IPC分类号： C07D215/08 , A61K31/437 , A61K31/4375 , A61K31/438 , A61K31/47 , A61K31/472 , A61K31/55 , A61P1/00 , A61P3/00 , A61P5/16 , A61P9/00 , A61P11/06 , A61P13/00 , A61P15/00 , A61P17/00 , A61P19/00 , A61P25/08 , A61P25/20 , A61P25/22 , A61P25/24 , A61P27/00 , A61P29/00 , A61P35/00 , A61P43/00 , C07D217/06 , C07D471/04 , C07D471/10 , C07D471/14 , C07D487/04
CPC分类号： C07D471/04
摘要： A compound represented by the general formula (I): A-X-Y-Z-B (I) (wherein A represents an optionally substituted cyclic group; X represents a bond or spacer; Y represents a bond or spacer; Z represents a bond or spacer; and B represents an optionally substituted hydrocarbon group or optionally substituted cyclic group), a salt of the compound, a solvate of the compound, or a prodrug of any of these. The compound represented by the general formula (I), salt, solvate, and prodrug are useful as a preventive and/or therapeutic agent for diseases attributable to stresses.
摘要翻译： 通式（I）表示的化合物AXYZB（I）（式中，A表示可以具有取代基的环状基团，X表示键或间隔基，Y表示键或间隔基，Z表示键或间隔基，B表示 任选取代的烃基或任选取代的环状基团），所述化合物的盐，所述化合物的溶剂合物或任何这些化合物的前药。 由通式（I）表示的化合物，盐，溶剂化物和前体药物可用作可归因于压力的疾病的预防和/或治疗剂。
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6.发明公开PREVENTIVE AND/OR THERAPEUTIC AGENT FOR DISEASE IN WHICH MITOCHONDRIAL BENZODIAZEPINE RECEPTOR PARTICIPATES 审中-公开预防和/或治疗剂疾病涉及线粒体苯二氮受体
公开(公告)号：EP1698335A4
公开(公告)日：2007-08-01
申请号：EP04808103
申请日：2004-12-24
发明人： OHMOTO K , KATO MASASHI , KATSUMATA S , MANAKO J
IPC分类号： A61K31/415 , A61K31/4155 , A61K31/416 , A61K31/4162 , A61K31/4164 , A61K31/417 , A61K31/4172 , A61K31/4184 , A61K31/496 , A61K45/00 , A61K45/06 , A61P1/04 , A61P9/06 , A61P9/12 , A61P11/02 , A61P11/06 , A61P13/00 , A61P15/00 , A61P15/10 , A61P15/12 , A61P25/00 , A61P25/08 , A61P25/16 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/28 , A61P43/00 , C07D231/38 , C07D231/56 , C07D233/54 , C07D233/64 , C07D409/12 , C07D487/04 , C07D495/04
CPC分类号： C07D409/12 , A61K31/496 , A61K45/06 , C07D231/38 , C07D233/64 , C07D487/04 , C07D495/04
摘要： A compound represented by the general formula (I): (I) (wherein ring A represents an optionally substituted nitrogenous ring; E represents a bond or a spacer having a C1-8 main chain; and Q represents hydrogen, an optionally substituted hydrocarbon group, or an optionally substituted cyclic group), a salt, N-oxide, or solvate of the compound, or a prodrug of any of these. The compound represented by the general formula (I), salt, N-oxide, solvate, and prodrug have an affinity for MBR and are hence useful as a preventive and/or therapeutic agent for diseases attributable to stresses.
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7.发明公开N-CARBAMOYL NITROGEN-CONTAINING FUSED RING COMPOUNDS AND DRUGS CONTAINING THESE COMPOUNDS AS THE ACTIVE INGREDIENT 审中-公开含氮N-氨基甲酰基稠环，和药物含有这些化合物作为活性CONTAIN
公开(公告)号：EP1475368A4
公开(公告)日：2006-03-29
申请号：EP03705105
申请日：2003-02-13
IPC分类号： A61P1/00 , A61P1/04 , A61P1/16 , A61P1/18 , A61P43/00 , C07D223/16 , C07D401/12 , A61K31/395 , A61K31/553 , A61K35/55 , C07D225/06 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D495/04
CPC分类号： C07D401/12 , C07D223/16
摘要： Compounds represented by the following general formula (I): (I) wherein each symbol is as defined in the description; mitochondrial benzodiazepine receptor (MBR) antagonists comprising these compounds; and preventives and/or remedies for diseases caused by stress which comprise the above compounds as the active ingredient. Because of having an MBR antagonistic activity and inhibiting the production of neurosteroids, the compounds represented by the general formula (I) are useful as preventives and/or remedies for diseases caused by stress.
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公开(公告)号：EP0997147A4
公开(公告)日：2000-10-11
申请号：EP98929830
申请日：1998-07-03
发明人： SEKO TAKUYA , KATO MASASHI
IPC分类号： A61K38/00 , C07C233/46 , C07C233/47 , C07C233/51 , C07C233/83 , C07C235/52 , C07C235/84 , C07C237/08 , C07C237/22 , C07C237/36 , C07C271/22 , C07C309/18 , C07C311/06 , C07C311/13 , C07C311/14 , C07C311/19 , C07C311/29 , C07C311/46 , C07C317/50 , C07C323/59 , C07C323/60 , C07C323/62 , C07D207/16 , C07D211/14 , C07D211/20 , C07D211/58 , C07D211/62 , C07D213/30 , C07D213/32 , C07D213/64 , C07D213/643 , C07D213/75 , C07D213/81 , C07D213/82 , C07D215/06 , C07D215/08 , C07D215/12 , C07D217/06 , C07D233/54 , C07D233/90 , C07D263/34 , C07D277/04 , C07D277/06 , C07D277/14 , C07D277/16 , C07D277/56 , C07D279/06 , C07D279/12 , C07D295/135 , C07D295/185 , C07D307/14 , C07D307/24 , C07D307/42 , C07D307/52 , C07D307/68 , C07D309/04 , C07D309/06 , C07D333/16 , C07D333/20 , C07D333/38 , C07D417/12 , C07K5/072 , C07K5/078 , A61K31/165 , A61K31/18 , A61K31/215 , A61K31/27 , A61K31/34 , A61K31/38 , A61K31/42 , A61K31/425 , A61K31/44 , A61K31/445
CPC分类号： C07D213/30 , A61K38/00 , C07C233/46 , C07C233/47 , C07C233/51 , C07C233/83 , C07C235/52 , C07C235/84 , C07C237/08 , C07C237/22 , C07C237/36 , C07C271/22 , C07C309/18 , C07C311/06 , C07C311/13 , C07C311/14 , C07C311/19 , C07C311/29 , C07C311/46 , C07C317/50 , C07C323/59 , C07C323/60 , C07C323/62 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/16 , C07C2601/18 , C07C2602/42 , C07C2603/74 , C07D207/16 , C07D211/14 , C07D211/20 , C07D211/58 , C07D211/62 , C07D213/32 , C07D213/64 , C07D213/643 , C07D213/75 , C07D213/81 , C07D213/82 , C07D215/06 , C07D215/08 , C07D215/12 , C07D217/06 , C07D233/64 , C07D233/90 , C07D263/34 , C07D277/04 , C07D277/06 , C07D277/14 , C07D277/16 , C07D277/56 , C07D279/06 , C07D279/12 , C07D295/135 , C07D295/185 , C07D307/14 , C07D307/24 , C07D307/42 , C07D307/52 , C07D307/68 , C07D309/04 , C07D309/06 , C07D333/16 , C07D333/20 , C07D333/38 , C07D417/12 , C07K5/06113 , C07K5/06139
摘要： Compounds represented by general formula (I), salts thereof and type N calcium channel inhibitors containing the same as the active ingredient, wherein R1 represents optionally substituted alkyl, alkoxy or phenyl, a heterocyclic group, etc.; A represents a single bond, CO or SO¿2; R?2 represents H, optionally substituted alkyl, etc.; D represents alkylene, etc.; E represents COO, OCO, O, S, SO, SO¿2?, etc.; R?3¿ represents optionally substituted alkyl, a carbocyclic group or a heterocycle group; J represents O or NR16 (wherein R16 represents H or optionally substituted alkyl); and R4 represents optionally substituted alkyl, a carbocyclic group or a heterocyclic group. Because of inhibiting the type N calcium channel, the compounds (I) are useful as preventives and/or remedies for cerebral infarction, transient cerebral ischemic attack, cerebrospinal disorders following heart operations, spinal vascular lesion, stress hypertension, neurosis, epilepsy, etc. or remdies for pains.
摘要翻译： 通式（I）表示的化合物，其盐以及含有它们作为活性成分的N型钙通道抑制剂，其中R 1表示任选取代的烷基，烷氧基或苯基，杂环基等; A代表单键，CO或SO 2; R 2表示H，任选取代的烷基等; D代表亚烷基等; E表示COO，OCO，O，S，SO，SO 2等; R 3'代表任意取代的烷基，碳环基团或杂环基团; J表示O或NR 16（其中R 16表示H或任选取代的烷基）; 并且R4代表任选取代的烷基，碳环基团或杂环基团。 由于抑制N型钙通道，化合物（I）可用作脑梗塞，短暂性脑缺血发作，心脏手术后的脑脊髓疾病，脊髓血管病变，压力性高血压，神经官能症，癫痫等的预防和/或治疗。 或改变痛苦。
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