发明授权
EP1720837B1 DERIVES DE N-'(1,5-DIPHENYL-1H-PYRAZOL-3-YL)METHYL SULFONAMIDE AVEC UNE AFFINITE POUR LES RECEPTEURS CB1
有权
N“ - （1,5-二苯基-1H-吡唑-3-基），其具有亲和力的CB 1受体磺酰胺衍生物
- 专利标题： DERIVES DE N-'(1,5-DIPHENYL-1H-PYRAZOL-3-YL)METHYL SULFONAMIDE AVEC UNE AFFINITE POUR LES RECEPTEURS CB1
- 专利标题（英）： Derivatives of n-' (1,5-diphenyl-1h-pyrazol-3-yl) sulphonamide with cb1 receptor affinity
- 专利标题（中）： N“ - （1,5-二苯基-1H-吡唑-3-基），其具有亲和力的CB 1受体磺酰胺衍生物
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申请号： EP05717379.1申请日： 2005-01-07
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公开(公告)号： EP1720837B1公开(公告)日： 2010-04-28
- 发明人: BARTH, Francis , CONGY, Christian , MARTINEZ, Serge , RINALDI-CARMONA, Murielle
- 申请人： Sanofi-Aventis
- 申请人地址： 174, Avenue de France 75013 Paris FR
- 专利权人： Sanofi-Aventis
- 当前专利权人： Sanofi-Aventis
- 当前专利权人地址： 174, Avenue de France 75013 Paris FR
- 代理机构： Kugel, Dominique
- 优先权： FR0400257 20040112
- 国际公布： WO2005073197 20050811
- 主分类号： C07D231/12
- IPC分类号： C07D231/12 ; A61K31/415 ; A61P25/00 ; C07D409/12 ; C07D413/14
摘要：
The invention relates to compounds having formula (I), the preparation method thereof and the use of same in therapeutics, wherein: R1 represents a (C1-C6)alkyl, a (C3-C7)cycloalkyl which is unsubstituted or is mono- or poly-substituted, a (C3-C7)cycloalkylmethyl which is unsubstituted or is mono- or poly-substituted, a phenyl which is unsubstituted or substituted; a benzyl which is unsubstituted or is mono- or disubstituted, a thienyl which is unsubstituted or substituted; R2 represents a hydrogen atom or a (C1-C3)alkyl; R3 represents a hydrogen atom or a (C1-C5)alkyl; R4, R5, R6, R7, R8 and R9 each represent, independently of each other, a hydrogen atom, a halogen atom, a (C1-C7)alkyl, a (C1-C5)alkoxy, a trifluoromethyl radical or a S(O)nAlk group; n represents 0, 1 or 2; and Alk represents a (C1-C4)alkyl. The invention also relates to the preparation method thereof and to the use of same in therapeutics.
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