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27 条记录 (耗时 0.019 秒)

    DERIVES DE N-'(1,5-DIPHENYL-1H-PYRAZOL-3-YL)METHYL SULFONAMIDE AVEC UNE AFFINITE POUR LES RECEPTEURS CB1
    3.
    发明授权
    DERIVES DE N-'(1,5-DIPHENYL-1H-PYRAZOL-3-YL)METHYL SULFONAMIDE AVEC UNE AFFINITE POUR LES RECEPTEURS CB1 有权
    N“ - （1,5-二苯基-1H-吡唑-3-基），其具有亲和力的CB 1受体磺酰胺衍生物

    公开(公告)号：EP1720837B1

    公开(公告)日：2010-04-28

    申请号：EP05717379.1

    申请日：2005-01-07

    申请人： Sanofi-Aventis

    发明人： BARTH, Francis ,  CONGY, Christian ,  MARTINEZ, Serge ,  RINALDI-CARMONA, Murielle

    IPC分类号： C07D231/12 ,  A61K31/415 ,  A61P25/00 ,  C07D409/12 ,  C07D413/14

    CPC分类号： C07D231/12 ,  C07D409/12 ,  C07D413/14

    摘要： The invention relates to compounds having formula (I), the preparation method thereof and the use of same in therapeutics, wherein: R1 represents a (C1-C6)alkyl, a (C3-C7)cycloalkyl which is unsubstituted or is mono- or poly-substituted, a (C3-C7)cycloalkylmethyl which is unsubstituted or is mono- or poly-substituted, a phenyl which is unsubstituted or substituted; a benzyl which is unsubstituted or is mono- or disubstituted, a thienyl which is unsubstituted or substituted; R2 represents a hydrogen atom or a (C1-C3)alkyl; R3 represents a hydrogen atom or a (C1-C5)alkyl; R4, R5, R6, R7, R8 and R9 each represent, independently of each other, a hydrogen atom, a halogen atom, a (C1-C7)alkyl, a (C1-C5)alkoxy, a trifluoromethyl radical or a S(O)nAlk group; n represents 0, 1 or 2; and Alk represents a (C1-C4)alkyl. The invention also relates to the preparation method thereof and to the use of same in therapeutics.

    DERIVES DE 1,5-DIARYLPYRROLE, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE
    4.
    发明公开
    DERIVES DE 1,5-DIARYLPYRROLE, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE 审中-公开
    1.5 DIARYLPYRROLDERIVATE，其制备方法及其在治疗中

    公开(公告)号：EP1853557A2

    公开(公告)日：2007-11-14

    申请号：EP06709331.0

    申请日：2006-02-16

    申请人： Sanofi-Aventis

    发明人： BARTH, Francis ,  CONGY, Christian ,  HORTALA, Laurent ,  RINALDI-CARMONA, Murielle

    IPC分类号： C07D207/32

    CPC分类号： C07D207/323 ,  C07D207/335 ,  C07D403/12

    摘要： The invention relates to compounds having formula (I), wherein: X represents a group having formula (II). According to the invention, R1 and R6 represent a hydrogen atom or an alkyl group. R2 represents a radical selected from among: a (C1-C12)alkyl; a non-aromatic carbocyclic radical at (C3-C12); a (C3-C7)cycloalkylmethyl; a phenyl, a benzyl, a benzhydryl, a benzhydrylmethyl, phenethyl, a benzodioxolyl, a dihydrobenzofuranyl, a dihydrobenzodioxinyl; a methyl substituted by a benzodioxolyl, a dihydrobenzofuranyl, a dihydrobenzodioxinyl; a non-substituted 1, 2, 3, 4-tetrahydronaphtalenyl; or a heterocyclic radical, an indolyl, a substituted or non-substituted benzothiazolyl, said radicals being substituted or non-substituted. R3 represents a (C1 -C5)alkyl or a (C3-C7) cycloalkyl. R4 and R5 represent a substituted or non-substituted phenyl. The invention also relates to a method of preparing said derivatives and to the application thereof in therapeutics.

    DERIVES D'OXAZOLE, LEUR PREPARATION ET LEUR UTILISATION EN THERAPEUTIQUE
    7.
    发明公开
    DERIVES D'OXAZOLE, LEUR PREPARATION ET LEUR UTILISATION EN THERAPEUTIQUE 审中-公开
    恶唑及其制备和治疗用途

    公开(公告)号：EP1716142A2

    公开(公告)日：2006-11-02

    申请号：EP05717611.7

    申请日：2005-02-11

    申请人： Sanofi-Aventis

    发明人： ARNAUD-TAILLADES, Joëlle ,  BARTH, Francis ,  CONGY, Christian ,  RINALDI-CARMONA, Murielle

    IPC分类号： C07D413/06 ,  C07D491/10 ,  C07D263/34

    CPC分类号： C07D263/34 ,  C07D413/06 ,  C07D491/10

    摘要： The invention relates to compounds of formula (I) where R1 = H or C1-C4 alkyl, R2 = C4-C10 alkyl, a C3-C12 non-aromatic carbocyclic group, a 1,2,3,4-tetrahydronaphthalenyl, a heterocyclic group, a C1-C3 alkylene group with a carbocyclic group, a phenylalkylene group, a NR9R10 group, or R1 and R2, together with the nitrogen atom to which they are bonded, are either a piperazin-1-yl or 1,4-diazepan-1-yl, or a piperidin-1-yl or pyrrolidin-1-yl, R3, R4, R5, R6, R7, R8 independently = H or halogen, a C1-C6 alkyl, C1-C6 alkoxy, trifluoromethyl or S(O)nAlk group in the form of a base or acid addition salts and in the hydrated or solvated state. The invention further relates to a method for preparation and therapeutic use thereof.