发明公开
EP1737430A1 METHOD OF PREPARING LOW-CRYSTALLINITY OLTIPRAZ OR AMORPHOUS OLTIPRAZ
审中-公开
用于生产低结晶或无定形的奥替普拉奥替普拉
- 专利标题： METHOD OF PREPARING LOW-CRYSTALLINITY OLTIPRAZ OR AMORPHOUS OLTIPRAZ
- 专利标题（中）： 用于生产低结晶或无定形的奥替普拉奥替普拉
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申请号： EP05726255.2申请日： 2005-01-27
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公开(公告)号： EP1737430A1公开(公告)日： 2007-01-03
- 发明人: CHO, Cheong-Weon , KANG, Kyoung-Rae , LEE, Sang-Ho , KU, Jeong , KIM, Taekrho , LEE, Sung-Hak , CHOI, Jae-Mook , CHEON, Jun-Hee , AN, Tae-Kun , PARK, Hyun-Jung , JEON, Eun-Kyung , CHOI, Kwang-Do , LIM, Jee-Woong , HONG, Kwang-Hee , HONG, Hyesuk , KIM, Il-Hwan , KIM, Tae-Hyoung , CHOI, Nak-Hyun , KIM, Young-Hoon , SUH, Hearan , JIN, Hae-Tak , YEON, Kyu-Jeong 126-801,Yeonwonmaeul Samho , KIM, Jinwan , MIN, In-Ki 601-1701 Gahyunmaeul Sinan Apt.,344,
- 申请人： CJ Corporation
- 申请人地址： 500 Namdaemunro 5-ga, Jung-gu Seoul 100-749 KR
- 专利权人： CJ Corporation
- 当前专利权人： CJ Corporation
- 当前专利权人地址： 500 Namdaemunro 5-ga, Jung-gu Seoul 100-749 KR
- 代理机构： Myon, Gérard Jean-Pierre
- 优先权： KR20040005000 20040127
- 国际公布： WO2005070397 20050804
- 主分类号： A61K9/16
- IPC分类号： A61K9/16 ; A61K31/4965 ; A61P1/16
摘要：
Provided is a method of preparing low-crystallinity oltipraz or amorphous oltipraz. The method includes: obtaining a mixed solution containing oltipraz and a water-soluble polymer or a water-insoluble polymer in a solvent, the solvent being an organic solvent or purified water; and solid-dispersing the oltipraz in the polymer. In the solid-dispersing, the mixed solution may be spray dried using a spray dryer or granulated using a fluid bed granulator.
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