公开(公告)号：EP1572982B1

公开(公告)日：2007-12-26

申请号：EP03812726.2

申请日：2003-12-10

申请人： CJ Corporation

发明人： KWAG, Young-Hyeon, 205-1116, Seongji Apt. 2 danji ,  OH, Ki-Hoon, 104, Hwagok Officetel ,  KIM, Jeong-Hwan ,  OH, Yoon-Suk ,  SIM, Jae-Ick ,  PARK, Young-Hoon ,  CHANG, Jea-Young

IPC分类号： C12N1/20

CPC分类号： C12P17/182 ,  C12R1/15

摘要： The invention relates to Corynebacterium ammoniagenes CJXSP 0201 KCCM 10448 producing 5'-xanthylic acid. More specifically, the invention relates to Corynebacterium ammoniagenes CJXSP 0201 KCCM 10448 which is a mutant strain of Corynebacterium ammoniagenes KCCM 10340 having a resistance to osmotic pressure. In order to obtain mutant strain having enhanced respiratory activity, the present invention adopted Corynebacterium ammoniagenes KCCM 10340 as parent strain and treated it with UV radiation and mutation derivatives such as N-methyl-N'-nitro-n-nitrosoguanidine(NTG) according to ordinary procedure. Therefore, Corynebacterium ammoniagenes CJXSP 0201 KCCM 10448 of the present invention makes it possible to overcome growth-standing phase rapidly on early culture and for same period of fermentation, can accumulate 5'-xanthylic acid in culture medium at a high yield and concentration rate.

公开(公告)号：EP1792975A1

公开(公告)日：2007-06-06

申请号：EP06256099.0

申请日：2006-11-29

申请人： CJ Corporation

发明人： Park, Young Hoon ,  Koo, Hyun Min ,  Lim, Sang Jo ,  Moon, Jun Ok ,  Yang, Young Lyeol

IPC分类号： C12N1/21 ,  C12N9/02 ,  C12P13/08

CPC分类号： C12R1/15 ,  C12N9/0004 ,  C12P13/08

摘要： The present invention provides a microorganism that belongs to the genus Corynebacterium and has an inactivated inherent NCgl2053 dehydrogenase gene, and a method of producing L-lysine using the same. By using the microorganism, the yield of L-lysine is increased since an inherent NCgl2053 dehydrogenase gene is inactivated. According to the method, L-lysine can be produced with high yield.

摘要翻译： 本发明提供的微生物那样属于棒状杆菌属并具有灭活的固有NCgl2053脱氢酶基因，和生产使用相同的L-赖氨酸的方法。 通过使用该微生物，L-赖氨酸的产率，因为其固有的NCgl2053脱氢酶增加基因失活。 。根据该方法，L-赖氨酸可以高成品率进行制造。

公开(公告)号：EP1694703A1

公开(公告)日：2006-08-30

申请号：EP04808311.7

申请日：2004-12-04

申请人： CJ Corporation

发明人： PARK, Ji-Sook ,  CHUNG, Jong-Sang ,  BAEK, Min-Ji ,  AHN, Jee-Won ,  KIM, Ki-Wan ,  PARK, Hyung-Ki ,  LEE, Dong-Eok ,  OH, Myung-Suk

IPC分类号： C07K14/565

CPC分类号： C07K14/565 ,  C12P21/02

摘要： Provided is a process for purifying human interferon beta from a recombinant human interferon beta-containing culture comprising performing affinity chromatography and cation exchange chromatography, wherein the affinity chromatography includes: adsorbing the interferon beta-containing culture to an equilibrated affinity chromatography column, followed by washing with an equilibration buffer solution; washing the column with a washing buffer solution A of pH 6.5-7.5 containing 30-60 wt% of propylene glycol and a washing buffer solution B of pH 6.5-7.5 containing 10-30 wt% of propylene glycol and 1-2M NaCl; and eluting a human interferon beta-containing fraction with a buffer solution of pH 6.5-7.5 containing 40-60 wt% of propylene glycol and 1-2M NaCl.

公开(公告)号：EP1692100A1

公开(公告)日：2006-08-23

申请号：EP04808357.0

申请日：2004-12-09

申请人： CJ Corporation

发明人： CHO, Seong-Hwan, 721-602 Hyundai Apt. ,  LIM, Dong-Kwon, 109-1301 Samsung Raemian 1cha Apt ,  LEE, Kwang-Hyeg, B-1103 Doosan We've Jennis Apt. ,  YOUN, Yong-Sik, 105-1004 Byuksan Apt. ,  PARK, Choong-Sil

IPC分类号： C07C303/40 ,  C07C311/37

CPC分类号： C07C303/40 ,  C07B2200/07 ,  C07C311/46

摘要： Provided is a method of preparing an optically pure compound having formula 1 or its salts. The method includes: reacting ®-2-(4-methoxy-3-aminosulfonyl-phenyl)-1-methylethylamine or its salts with a compound selected form the group consisting of chloroacetic acid, bromoacetic acid, fluoroacetic acid, iodoacetic acid, α-halogenoacetic acid anhydride, and α-halogenoacetyl halide in the presence of a base or an acylating agent.

公开(公告)号：EP1612216A1

公开(公告)日：2006-01-04

申请号：EP04356158.8

申请日：2004-09-24

申请人： CJ Corporation

发明人： Lee, Ju Won ,  Jung, Yun Taek ,  Suh, Jung Woo ,  Lee, Kwang Seob

IPC分类号： C07K9/00 ,  C07K1/20

CPC分类号： C07K9/008

摘要： Provided is a method of purifying a vancomycin from a fermentation broth of a microorganism containing vancomycin, including passing the fermentation broth of a microorganism containing vancomycin through a strong acid cation exchange resin, a weak base anion exchange resin, alumina and a hydrophobic absorbent resin sequentially.

摘要翻译： 本发明提供了从含有万古霉素的微生物的发酵液中提纯万古霉素的方法，包括使含有万古霉素的微生物的发酵液通过强酸阳离子交换树脂，弱碱阴离子交换树脂，氧化铝和疏水性吸水树脂顺序地通过 。

公开(公告)号：EP1572982A1

公开(公告)日：2005-09-14

申请号：EP03812726.2

申请日：2003-12-10

申请人： CJ Corporation

发明人： KWAG, Young-Hyeon,205-ho Domitory for man ,  OH, Ki-Hoon ,  KIM, Jeong-Hwan ,  OH, Yoon-Suk ,  SIM, Jae-Ick ,  PARK, Young-Hoon ,  CHANG, Jea-Young

IPC分类号： C12N1/20

CPC分类号： C12P17/182 ,  C12R1/15

摘要： The invention relates to Corynebacterium ammoniagenes CJXSP 0201 KCCM 10448 producing 5'-xanthylic acid. More specifically, the invention relates to Corynebacterium ammoniagenes CJXSP 0201 KCCM 10448 which is a mutant strain of Corynebacterium ammoniagenes KCCM 10340 having a resistance to osmotic pressure. In order to obtain mutant strain having enhanced respiratory activity, the present invention adopted Corynebacterium ammoniagenes KCCM 10340 as parent strain and treated it with UV radiation and mutation derivatives such as N-methyl-N'-nitro-n-nitrosoguanidine(NTG) according to ordinary procedure. Therefore, Corynebacterium ammoniagenes CJXSP 0201 KCCM 10448 of the present invention makes it possible to overcome growth-standing phase rapidly on early culture and for same period of fermentation, can accumulate 5'-xanthylic acid in culture medium at a high yield and concentration rate.

公开(公告)号：EP1565447A1

公开(公告)日：2005-08-24

申请号：EP03774331.7

申请日：2003-11-26

申请人： CJ Corporation

发明人： CHO, Il-Hwan ,  KO, Dong-Hyun ,  CHAE, Myeong-Yun ,  MIN, In-Ki,601-1701 Gahyunmaeul Sinan Apt. ,  KIM, Young-Hoon,103-902 Daewoo Apt. ,  YEON, Kyu-J.,126-801 Yeonwonmaeul Samhobyuksan A. ,  KIM, Jong-Hoon,503-503 Gongjaklucky Apt. ,  JUNG, Sung-Hak ,  PARK, Sang-Wook ,  KIM, Il-Hwan ,  RYU, Hyung-Chul ,  NOH, Ji-Young,Rm. 503 Byuksangreenvilla ,  PARK, Hyun-Jung ,  PARK, Jie-Eun ,  CHUNG, Young-Mee

IPC分类号： C07D249/12

CPC分类号： C07D249/12 ,  C07D249/10

摘要： A 1,2,4-triazole derivative of formula 1 or a non-toxic salt thereof, a preparation method thereof, and a pharmaceutical composition containing the derivative or the salt as an active ingredient are provided.

公开(公告)号：EP1426450A1

公开(公告)日：2004-06-09

申请号：EP03253625.2

申请日：2003-06-09

申请人： CJ Corporation

发明人： Lee, Kyung Han ,  Choi, Hyang ,  Lee, Kwang Ho, 809-1401 Kyundai Sungwoo Apt. ,  Han, Jong Kwon ,  Park, Young Hoon ,  Park, Jang Hee

IPC分类号： C12R1/125 ,  C12P25/00

CPC分类号： C12R1/125 ,  C12P25/00

摘要： Riboflavin-producing Bacillus subtilis which is resistant to proline analogue, and a method for producing riboflavin using the Bacillus subtilis are provided.

摘要翻译： 提供了对脯氨酸类似物具有抗性的产生核黄素的枯草芽孢杆菌，以及使用枯草芽孢杆菌生产核黄素的方法。

公开(公告)号：EP1415572A1

公开(公告)日：2004-05-06

申请号：EP03011144.7

申请日：2003-05-23

申请人： CJ Corporation ,  Kweon, Young Jun ,  Kwon, Sung Wook

发明人： CJ Corporation ,  Kweon, Young Jun ,  Kwon, Sung Wook

IPC分类号： A46B9/04 ,  A61C17/22

CPC分类号： A46D1/0284 ,  A46B9/045 ,  Y10S15/05

摘要： Disclosed is a toothbrush having soft and hard bristles together. The toothbrush having soft and hard bristles with 6-10mm in tapered length and 0.01 - 0.08mm in diameter of end portions comprises: longer bristles(1) located at both edges; and shorter bristles(2) located at the central portion, wherein the bristles are generally in a semicircular form at their top portions when seen from a side, and a difference in length between the longer bristles(1) and the shorter bristles(2) is about 2 - 4mm. The toothbrush can increase brushing efficiency and effectively remove foreign matters between teeth and inside periodontal pockets.

摘要翻译： 较长的刷毛（1）位于两个边缘，而较短的刷毛（2）位于中心部分。 当从任一侧观察时，刷毛在其顶部部分通常为半圆形。 长短毛之间的长度差异在2到4毫米之间。

公开(公告)号：EP1400512A1

公开(公告)日：2004-03-24

申请号：EP03019777.6

申请日：2003-08-29

申请人： CJ Corporation

发明人： Lim, Dong Kwon ,  Lee, Hyuk Koo ,  Suh, Hea Ran ,  Cho, Seong Hwan ,  Lee, Kwang Hyeg ,  Kim, Yun Cheul ,  Jung, Sung Hak ,  Lee, Sung Hak ,  Kang, Hyun Suk ,  Park, Kyung Mi ,  Jung, Yun Taek ,  Cheon, Jun Hee ,  Park, Choong Sil ,  Youn, Yong Sik ,  Kim, Young Hoon ,  Yeon, Kyu Jeong ,  Chae, Myeong Yun ,  Jin, Hae Tak

IPC分类号： C07D211/90

CPC分类号： C07D211/90

摘要： A novel crystalline organic acid salt of amlodipine having improved physiochemical properties, a preparation method thereof and a pharmaceutical composition comprising the same are provided.

摘要翻译： 提供具有改善的生理化学性质的新颖的氨氯地平结晶有机酸盐，其制备方法和包含其的药物组合物。