公开(公告)号：EP1565447A1

公开(公告)日：2005-08-24

申请号：EP03774331.7

申请日：2003-11-26

申请人： CJ Corporation

发明人： CHO, Il-Hwan ,  KO, Dong-Hyun ,  CHAE, Myeong-Yun ,  MIN, In-Ki,601-1701 Gahyunmaeul Sinan Apt. ,  KIM, Young-Hoon,103-902 Daewoo Apt. ,  YEON, Kyu-J.,126-801 Yeonwonmaeul Samhobyuksan A. ,  KIM, Jong-Hoon,503-503 Gongjaklucky Apt. ,  JUNG, Sung-Hak ,  PARK, Sang-Wook ,  KIM, Il-Hwan ,  RYU, Hyung-Chul ,  NOH, Ji-Young,Rm. 503 Byuksangreenvilla ,  PARK, Hyun-Jung ,  PARK, Jie-Eun ,  CHUNG, Young-Mee

IPC分类号： C07D249/12

CPC分类号： C07D249/12 ,  C07D249/10

摘要： A 1,2,4-triazole derivative of formula 1 or a non-toxic salt thereof, a preparation method thereof, and a pharmaceutical composition containing the derivative or the salt as an active ingredient are provided.

公开(公告)号：EP1737430A1

公开(公告)日：2007-01-03

申请号：EP05726255.2

申请日：2005-01-27

申请人： CJ Corporation

发明人： CHO, Cheong-Weon ,  KANG, Kyoung-Rae ,  LEE, Sang-Ho ,  KU, Jeong ,  KIM, Taekrho ,  LEE, Sung-Hak ,  CHOI, Jae-Mook ,  CHEON, Jun-Hee ,  AN, Tae-Kun ,  PARK, Hyun-Jung ,  JEON, Eun-Kyung ,  CHOI, Kwang-Do ,  LIM, Jee-Woong ,  HONG, Kwang-Hee ,  HONG, Hyesuk ,  KIM, Il-Hwan ,  KIM, Tae-Hyoung ,  CHOI, Nak-Hyun ,  KIM, Young-Hoon ,  SUH, Hearan ,  JIN, Hae-Tak ,  YEON, Kyu-Jeong 126-801,Yeonwonmaeul Samho ,  KIM, Jinwan ,  MIN, In-Ki 601-1701 Gahyunmaeul Sinan Apt.,344,

IPC分类号： A61K9/16 ,  A61K31/4965 ,  A61P1/16

CPC分类号： A61K9/1635 ,  A61K9/1652 ,  A61K9/2027 ,  A61K9/2054 ,  A61K31/497 ,  A61K31/724 ,  C07D409/04

摘要： Provided is a method of preparing low-crystallinity oltipraz or amorphous oltipraz. The method includes: obtaining a mixed solution containing oltipraz and a water-soluble polymer or a water-insoluble polymer in a solvent, the solvent being an organic solvent or purified water; and solid-dispersing the oltipraz in the polymer. In the solid-dispersing, the mixed solution may be spray dried using a spray dryer or granulated using a fluid bed granulator.