公开(公告)号：EP1673073A1

公开(公告)日：2006-06-28

申请号：EP04774738.1

申请日：2004-09-25

申请人： CJ Corporation

发明人： CHO, Seong-Hwan ,  KU, Jeong ,  LIM, Dong-Kwon ,  CHEON, Jun-Hee ,  AN, Tae-Kun ,  KO, Jae-Kyoung ,  YOUN, Yong-Sik ,  PARK, Choong-Sil ,  SUH, Hea-Ran, CJ R & D Center of Pharmaceuticals ,  YANG, Eun-Young ,  JEON, Eun-Kyung ,  KIM, Chang-Ju

IPC分类号： A61K9/22

CPC分类号： A61K9/209

摘要： Provided is a sustained-release formulation: (a) a sustained-release core including an active ingredient and a polymer having erosion and swelling property in mammalian intestinal secretions, (b) an enteric film coating layer coated on the sustained-release core, and (c) an active ingredient-containing film coating layer coated on the enteric film coating layer and including the active ingredient and hydrophilic polymer for film coating.

公开(公告)号：EP1737430A1

公开(公告)日：2007-01-03

申请号：EP05726255.2

申请日：2005-01-27

申请人： CJ Corporation

发明人： CHO, Cheong-Weon ,  KANG, Kyoung-Rae ,  LEE, Sang-Ho ,  KU, Jeong ,  KIM, Taekrho ,  LEE, Sung-Hak ,  CHOI, Jae-Mook ,  CHEON, Jun-Hee ,  AN, Tae-Kun ,  PARK, Hyun-Jung ,  JEON, Eun-Kyung ,  CHOI, Kwang-Do ,  LIM, Jee-Woong ,  HONG, Kwang-Hee ,  HONG, Hyesuk ,  KIM, Il-Hwan ,  KIM, Tae-Hyoung ,  CHOI, Nak-Hyun ,  KIM, Young-Hoon ,  SUH, Hearan ,  JIN, Hae-Tak ,  YEON, Kyu-Jeong 126-801,Yeonwonmaeul Samho ,  KIM, Jinwan ,  MIN, In-Ki 601-1701 Gahyunmaeul Sinan Apt.,344,

IPC分类号： A61K9/16 ,  A61K31/4965 ,  A61P1/16

CPC分类号： A61K9/1635 ,  A61K9/1652 ,  A61K9/2027 ,  A61K9/2054 ,  A61K31/497 ,  A61K31/724 ,  C07D409/04

摘要： Provided is a method of preparing low-crystallinity oltipraz or amorphous oltipraz. The method includes: obtaining a mixed solution containing oltipraz and a water-soluble polymer or a water-insoluble polymer in a solvent, the solvent being an organic solvent or purified water; and solid-dispersing the oltipraz in the polymer. In the solid-dispersing, the mixed solution may be spray dried using a spray dryer or granulated using a fluid bed granulator.

公开(公告)号：EP1458359A1

公开(公告)日：2004-09-22

申请号：EP02793523.8

申请日：2002-12-26

申请人： CJ Corporation

发明人： CHOI, Jae-Mook ,  JEON, Eun-Kyung ,  KO, Jae-Kyoung ,  PARK, Young-Hwan ,  BAEK, Myoung-Ki ,  YANG, Su-Geun ,  JEONG, Eun-Ju101-1102 Mokhwa Apt. 414

IPC分类号： A61K9/107

CPC分类号： A61K9/1075 ,  A61K9/4858

摘要： A microemulsion preconcentrate is provided, which comprises an active component, an oil, a surfactant, and a hydrophilic solvent selected from the group consisting of propylene glycol diacetate, propylene glycol monoacetate, and salts of the forgoing materials.