发明公开
- 专利标题： Recombinant alpha-L-iduronidase, methods for producing and purifying the same and methods for treating diseases caused by deficiences thereof
- 专利标题（中）： 德国巴斯夫·德尔·德·卢克斯
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申请号： EP06011595.3申请日： 2000-11-09
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公开(公告)号： EP1792983A1公开(公告)日： 2007-06-06
- 发明人: Henstrand, John M. , Qin, Minmin , Chan, Wia-Pan , Chen, Lin , Fitzpatrick, Paul A. , Wendt, Dan J. , Zecherle, Gary N. , Starr, Christopher M. , Kakkis, Emil D. , Tanamachi, Becky
- 申请人： Biomarin Pharmaceutical Inc. , Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center
- 申请人地址： 105 Digital Drive Novato CA 94949 US
- 专利权人： Biomarin Pharmaceutical Inc.,Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center
- 当前专利权人： Biomarin Pharmaceutical Inc.,Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center
- 当前专利权人地址： 105 Digital Drive Novato CA 94949 US
- 代理机构： Richards, William John
- 优先权： US439923 19991112
- 主分类号： C12N9/24
- IPC分类号： C12N9/24 ; A61K38/47 ; A61P3/00
摘要：
The present invention provides a recombinant human α-L-iduronidase and biologically active fragments and mutants thereof, large scale methods to produce and purify commercial grade recombinant human, α-L-iduronidase enzyme as well as methods to treat certain genetic disorders including α-L-iduronidase deficiency and mucopolysaccharidosis I (MPS 1).
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