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    Mesenchymal stem cell conditioned medium
    6.
    发明公开
    Mesenchymal stem cell conditioned medium 审中-公开
    Mit间充质Stammzellen konditioniertes中等

    公开(公告)号：EP2617428A1

    公开(公告)日：2013-07-24

    申请号：EP13164423.9

    申请日：2007-08-15

    申请人： Agency for Science, Technology and Research

    发明人： Lye, Elias ,  Lim, Sai Kiang

    IPC分类号： A61K35/28 ,  C12N5/071

    CPC分类号： A61K35/28 ,  C12N5/0018 ,  C12N5/0606 ,  C12N5/0611 ,  C12N5/0662 ,  C12N5/0663 ,  C12N5/0668 ,  C12N2500/90 ,  C12N2500/99 ,  C12N2501/115 ,  C12N2501/135 ,  C12N2506/02 ,  C12N2509/00

    摘要： We disclose a method of preparing a conditioned cell culture medium, the method comprising the steps of: (a) culturing a mesenchymal stem cell (MSC), a descendent thereof or a cell line derived therefrom in a cell culture medium; and (b) optionally isolating the cell culture medium; in which the mesenchymal stem cell (MSC) is obtained by propagating a cell obtained by dispersing a embryonic stem (ES) cell colony, or a descendent thereof, in the absence of co-culture in a serum free medium comprising FGF2.

    摘要翻译： 我们公开了一种制备条件细胞培养基的方法，所述方法包括以下步骤：（a）在细胞培养基中培养间充质干细胞（MSC），其后代或由其衍生的细胞系; 和（b）任选地分离细胞培养基; 其中间充质干细胞（MSC）是通过在不含共培养的情况下将包含FGF2的无血清培养基分散胚胎干（ES）细胞集落或其后代所获得的细胞获得的。

    GLUCOSE SENSOR
    8.
    发明公开
    GLUCOSE SENSOR 审中-公开
    血糖仪

    公开(公告)号：EP2499164A2

    公开(公告)日：2012-09-19

    申请号：EP10796091.6

    申请日：2010-11-11

    申请人： King's College London

    发明人： PICKUP, John ,  KHAN, Faaizah

    IPC分类号： C07K17/00

    CPC分类号： G01N33/66 ,  C07K17/06 ,  G01N33/54313 ,  G01N33/545 ,  G01N33/582

    摘要： The invention relates to a glucose binding protein comprising amino acid mutations relative to the wild type sequence at the following positions: (i) H 152, (ii) A213; and (iii) L238 wherein the mutation at position H 152 is H152C. The invention further relates to such a glucose binding protein comprising the mutations H152C, A213R and L238S, in particular when linked to an environmentally sensitive dye such as badan.

    INCORPORATION OF METHYL LYSINE INTO POLYPEPTIDES
    9.
    发明公开
    INCORPORATION OF METHYL LYSINE INTO POLYPEPTIDES 审中-公开
    N-甲基赖氨酸的INSET多肽中

    公开(公告)号：EP2483397A2

    公开(公告)日：2012-08-08

    申请号：EP10777063.8

    申请日：2010-10-01

    申请人： Medical Research Council

    发明人： CHIN, Jason ,  NGUYEN, Duy, P.

    IPC分类号： C12N9/00

    CPC分类号： C07K14/47 ,  C12N9/93 ,  C12P21/02 ,  G01N33/566

    摘要： The invention relates to A method of making a polypeptide comprising at least one N
    ε -methyl-lysine at a specific site in said polypeptide, said method comprising (a) genetically directing the incorporation of R-N
    ε -methyl-lysine into said polypeptide, wherein R comprises an auxiliary group; and (b) catalysing the removal of R from the polypeptide of (a). In particular the invention relates to such a method wherein genetically directing the incorporation of R- Nε-methyl-lysine into said polypeptide comprises arranging for the translation of a RNA encoding said polypeptide, wherein said RNA comprises an amber codon, and wherein said translation is carried out in the presence of an amber tRNA charged with R-N
    ε -methyl-lysine.

    MODULATION OF SGK1 EXPRESSION IN TH17 CELLS TO MODULATE TH17-MEDIATED IMMUNE RESPONSES
    10.
    发明公开
    MODULATION OF SGK1 EXPRESSION IN TH17 CELLS TO MODULATE TH17-MEDIATED IMMUNE RESPONSES 审中-公开
    调制剂SGK1-表达BEI TH17-ZELLEN ZUR MODULATION VON TH17-VERMITTELTEN IMMUNREAKINGEN

    公开(公告)号：EP2459184A1

    公开(公告)日：2012-06-06

    申请号：EP10740108.5

    申请日：2010-07-30

    申请人： The Brigham and Women's Hospital, Inc.

    发明人： KUCHROO, Vijay K. ,  JIN, Hulin

    IPC分类号： A61K31/015 ,  A61K31/404 ,  A61K31/437 ,  A61P37/00

    CPC分类号： A61K31/404 ,  A61K31/407 ,  A61K31/437 ,  A61K39/39 ,  A61K2039/55511 ,  A61K2039/57 ,  Y02A50/386 ,  Y02A50/388

    摘要： The inventors have made the surprising discovery that SGK1, a serine/threonine kinase previously described as being involved in regulation of cellular sodium homeostasis, has a novel and unexpected function in the differentiation and function of a specific subset of CD4 T cells, the TH17 lineage. Described herein are methods and compositions for modulation of TH17 cell differentiation, proliferation, and/or function that rely upon modulating the activity or expression of SGK1. Such methods and compositions are useful in the treatment of disorders including autoimmune diseases, chronic inflammatory conditions, infectious diseases, and cancer.

    摘要翻译： 本发明人已经令人惊奇地发现，SGK1（丝氨酸/苏氨酸激酶以前被描述为参与细胞钠稳态调节）在CD4T细胞特异性子集的分化和功能中具有新颖和意想不到的功能，TH17谱系 。 本文描述了用于调节依赖于调节SGK1的活性或表达的TH17细胞分化，增殖和/或功能的方法和组合物。 这些方法和组合物可用于治疗包括自身免疫性疾病，慢性炎性病症，感染性疾病和癌症的疾病。