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1.发明授权RECOMBINANT ALPHA-L-IDURONIDASE AND METHODS FOR TREATING DISEASES CAUSED BY DEFICIENCIES THEREOF 有权重组α-L-艾杜糖醛酸和治疗这导致营养缺乏病
公开(公告)号：EP1792983B1
公开(公告)日：2009-04-29
申请号：EP06011595.3
申请日：2000-11-09
申请人： BioMarin Pharmaceutical Inc. , Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center
发明人： Henstrand, John M. , Qin, Minmin , Chan, Wia-Pan , Chen, Lin , Fitzpatrick, Paul A. , Wendt, Dan J. , Zecherle, Gary N. , Starr, Christopher M. , Kakkis, Emil D. , Tanamachi, Becky
CPC分类号： C12N9/88 , A61K38/47 , A61K48/00 , C12N9/2402 , C12Y302/01014 , C12Y302/01075 , C12Y302/01076 , C12Y402/02004
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2.发明公开
公开(公告)号：EP1792983A1
公开(公告)日：2007-06-06
申请号：EP06011595.3
申请日：2000-11-09
申请人： Biomarin Pharmaceutical Inc. , Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center
发明人： Henstrand, John M. , Qin, Minmin , Chan, Wia-Pan , Chen, Lin , Fitzpatrick, Paul A. , Wendt, Dan J. , Zecherle, Gary N. , Starr, Christopher M. , Kakkis, Emil D. , Tanamachi, Becky
CPC分类号： C12N9/88 , A61K38/47 , A61K48/00 , C12N9/2402 , C12Y302/01014 , C12Y302/01075 , C12Y302/01076 , C12Y402/02004
摘要： The present invention provides a recombinant human α-L-iduronidase and biologically active fragments and mutants thereof, large scale methods to produce and purify commercial grade recombinant human, α-L-iduronidase enzyme as well as methods to treat certain genetic disorders including α-L-iduronidase deficiency and mucopolysaccharidosis I (MPS 1).
摘要翻译： 本发明提供了重组人±-L-艾杜糖醛酸酶及其生物活性片段和突变体，大规模生产和纯化商业级重组人，±-L-艾杜糖醛酶的方法以及治疗某些遗传疾病的方法，包括± L-iduronidase缺乏和粘多糖贮积症I（MPS 1）。
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3.发明授权Precursor N-acetylgalactosamine-4-sulfatase, methods of treatment using said enzyme and methods for producing and purifying said enzyme 有权前体N-乙酰-4-硫酸酯酶，使用这种酶的生产和纯化这种酶和方法进行治疗的方法
公开(公告)号：EP2327414B1
公开(公告)日：2015-01-07
申请号：EP10011421.4
申请日：2003-11-07
发明人： Qin, Minmin , Henstrand, John M. , Zecherle, Gary N. , Wendt, Dan J. , Chan, Wai-Pan , Chen, Lin , Fitzpatrick, Paul A. , Starr, Christopher M. , Swiedler, Stuart
CPC分类号： B01D15/3804 , A61K38/00 , B01D15/327 , B01D15/3828 , C12N9/16 , C12Y301/06012
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