发明公开
EP1877394A1 PROCESS FOR THE PREPARATION OF ESCITALOPRAM OR ITS ACID ADDITION SALTS
审中-公开
用于生产依他普仑或其及其酸加成盐
- 专利标题： PROCESS FOR THE PREPARATION OF ESCITALOPRAM OR ITS ACID ADDITION SALTS
- 专利标题（中）： 用于生产依他普仑或其及其酸加成盐
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申请号： EP06728421.6申请日： 2006-04-04
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公开(公告)号： EP1877394A1公开(公告)日： 2008-01-16
- 发明人: DAS, Prasenjit Prafulla , GOANKAR, Santosh Laxman , MANJUNATHA, Sulur, G. , NARAHARI BABU, Ambati
- 申请人： Jubilant Organosys Limited
- 申请人地址： Plot No1-A, Sector 16A, Institutional Area Noida 201 301, Uttar Pradesh IN
- 专利权人： Jubilant Organosys Limited
- 当前专利权人： Jubilant Organosys Limited
- 当前专利权人地址： Plot No1-A, Sector 16A, Institutional Area Noida 201 301, Uttar Pradesh IN
- 代理机构： Senior, Janet
- 优先权： INDE08562005 20050404
- 国际公布： WO2006106531 20061012
- 主分类号： C07D307/87
- IPC分类号： C07D307/87
摘要：
The present invention relates to Formula (I), a process for the preparation of highly pure Escitalopram or its acid addition salts which comprises: a) reacting racemic diol or its ester derivative (III) with an optically active acid and at least one solvent to get enantiomerically pure diastereomer (IIIA); b) separating the enantiomerically pure diastereomer (IIIA) from its optically active acid salt by treating it with base and followed by stereo selective cyclization; c) separating the Escitalopram base.
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