发明公开
EP1882697A1 Post-translationally modified neurotrophins
有权
Antikörper，Antikörperfragmenteund scFv死于翻译后修饰物神经营养蛋白
- 专利标题： Post-translationally modified neurotrophins
- 专利标题（中）： Antikörper，Antikörperfragmenteund scFv死于翻译后修饰物神经营养蛋白
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申请号： EP06291195.3申请日： 2006-07-24
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公开(公告)号： EP1882697A1公开(公告)日： 2008-01-30
- 发明人: Barbeito, Luis , Pehar, Mariana , Cassina, Patricia , Alzari, Pedro M.
- 申请人： INSTITUT PASTEUR , Instituto de Investigaciones Biologicas Clemente Estable (I.I.B.C.E.) , Facultad de Medicina, Universidad de la Republica
- 申请人地址： 25-28, rue du Docteur Roux 75724 Paris Cédex 15 FR
- 专利权人： INSTITUT PASTEUR,Instituto de Investigaciones Biologicas Clemente Estable (I.I.B.C.E.),Facultad de Medicina, Universidad de la Republica
- 当前专利权人： INSTITUT PASTEUR,Instituto de Investigaciones Biologicas Clemente Estable (I.I.B.C.E.),Facultad de Medicina, Universidad de la Republica
- 当前专利权人地址： 25-28, rue du Docteur Roux 75724 Paris Cédex 15 FR
- 代理机构： Paris, Fabienne
- 主分类号： C07K14/48
- IPC分类号： C07K14/48 ; C07K14/475 ; C07K1/107 ; G01N33/53 ; C07K16/22 ; A61P25/00 ; A61K38/18 ; A61K39/395
摘要：
The present invention describes that neurotrophins undergo post-translational modifications, and that these post-translational modifications mediate the pro-apoptotic and/or pro-neurite activity of neurotrophins. These post-translational modifications notably include nitration and the formation of conformationally-different dimers, as well as of abnormal oligomers, such as tetramers and octamers. The invention further relates to compounds that compete with such modified neurotrophins, as well as to compounds that binds to said modified neurotrophins. The invention thus provides useful agents for the treatment of the conditions or diseases involving chronic pain and/or neuron loss.
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