发明公开
EP1911746A1 THE SUBSTANCE HAVING ANTIOXIDANT, GEROPROTECTIVE AND ANTI-ISCHEMIC ACTIVITY AND METHOD FOR PREPARING THEREOF
有权
具有抗氧化物质，抗心肌缺血GEROPROTEKTIVER及作用，及其方法
- 专利标题： THE SUBSTANCE HAVING ANTIOXIDANT, GEROPROTECTIVE AND ANTI-ISCHEMIC ACTIVITY AND METHOD FOR PREPARING THEREOF
- 专利标题（中）： 具有抗氧化物质，抗心肌缺血GEROPROTEKTIVER及作用，及其方法
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申请号： EP05807224.0申请日： 2005-07-11
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公开(公告)号： EP1911746A1公开(公告)日： 2008-04-16
- 发明人: SMIPNOV, Leonid Dmitrievich , OSTROVSKY, Michail Arkadievich , SIPYAGIN, Aleksey Michailovich , DONCOV, Aleksandr, Evgenievich
- 申请人： Marvel Lifesciences Limited
- 申请人地址： Raebarn House, 100 Northolt Road, Harrow Middlesex HA5 OYJ GB
- 专利权人： Marvel Lifesciences Limited
- 当前专利权人： Marvel Lifesciences Limited
- 当前专利权人地址： Raebarn House, 100 Northolt Road, Harrow Middlesex HA5 OYJ GB
- 代理机构： Henrion, Oliver
- 国际公布： WO2007017713 20070215
- 主分类号： C07D213/30
- IPC分类号： C07D213/30 ; A61K31/4412 ; A61P27/02 ; A61P9/10
摘要：
The invention relates to the field of medicine, namely to new biologically active compounds, particularly to 2,4,6-trimethyl-3-hydroxypyridine derivatives and salts thereof (compound 1) having antioxidant, geroprotective and anti-ischemic action. The salts of compound (1) are prepared by reacting equimolecular quantities of 2,4,6-trimethyl-3-hydroxypyridine and dicarboxylic in solution of a lower alcohol at a temperature of 60-100°C with following treatment of the reaction mass with an organic solvent and maintaining for 2-5 h at 10-15 °C.
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