公开(公告)号：EP1911746A1

公开(公告)日：2008-04-16

申请号：EP05807224.0

申请日：2005-07-11

申请人： Marvel Lifesciences Limited

发明人： SMIPNOV, Leonid Dmitrievich ,  OSTROVSKY, Michail Arkadievich ,  SIPYAGIN, Aleksey Michailovich ,  DONCOV, Aleksandr, Evgenievich

IPC分类号： C07D213/30 ,  A61K31/4412 ,  A61P27/02 ,  A61P9/10

CPC分类号： C07D213/65 ,  C07D213/30

摘要： The invention relates to the field of medicine, namely to new biologically active compounds, particularly to 2,4,6-trimethyl-3-hydroxypyridine derivatives and salts thereof (compound 1) having antioxidant, geroprotective and anti-ischemic action. The salts of compound (1) are prepared by reacting equimolecular quantities of 2,4,6-trimethyl-3-hydroxypyridine and dicarboxylic in solution of a lower alcohol at a temperature of 60-100°C with following treatment of the reaction mass with an organic solvent and maintaining for 2-5 h at 10-15 °C.

摘要翻译： 本发明涉及医学领域，即新的生物活性化合物，特别是2,4,6-三甲基-3-羟基吡啶衍生物及其盐（化合物1），其具有抗氧化，老年性保护和抗局部缺血作用。 化合物（1）的盐是通过在60-100℃的温度下与处理后的反应物料进行反应在低级醇的溶液2,4,6-三甲基-3-羟基吡啶和二羧酸的等摩尔量制备 在有机溶剂中和在10-15℃下保持2-5ħ

公开(公告)号：EP1911746B1

公开(公告)日：2009-08-26

申请号：EP05807224.0

申请日：2005-07-11

申请人： Marvel Lifesciences Limited

发明人： SMIPNOV, Leonid Dmitrievich ,  OSTROVSKY, Michail Arkadievich ,  SIPYAGIN, Aleksey Michailovich ,  DONCOV, Aleksandr, Evgenievich

IPC分类号： C07D213/30 ,  A61K31/4412 ,  A61P27/02 ,  A61P9/10

CPC分类号： C07D213/65 ,  C07D213/30

摘要： The invention relates to the field of medicine, namely to new biologically active compounds, particularly to 2,4,6-trimethyl-3-hydroxypiridine derivatives and salts thereof (compound 1), having antioxidant, geroprotective and anti-ischemic action. The salts of compound (1) are prepared by reacting equimolecular quantities of 2,4,6-trimethyl-3-hydroxypiridine and dicarboxylic in solution of the lower spirit at the temperature of 60-100°C with following processing of the reactionary bulk by organic solvent and incubating within 2-5 h at 10-15°C.