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公开(公告)号：EP2265253A2
公开(公告)日：2010-12-29
申请号：EP09722113.9
申请日：2009-02-19
CPC分类号： A61K31/44 , A61K9/0007 , A61K9/0095 , A61K9/1652 , A61K9/2054 , A61K9/2059 , A61K9/2866
摘要： An oral pharmaceutical composition comprising 3-hydroxy 2,4,6 trimethylpyridine, pharmaceutically acceptable salts, esters, derivatives and polymorphs thereof for the treatment of ischemia, intraocular hemorrhage and macular degeneration is disclosed.
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2.发明授权THE SUBSTANCE HAVING ANTIOXIDANT, GEROPROTECTIVE AND ANTI-ISCHEMIC ACTIVITY AND METHOD FOR PREPARING THEREOF 有权具有抗氧化物质，抗心肌缺血GEROPROTEKTIVER及作用，及其方法
公开(公告)号：EP1911746B1
公开(公告)日：2009-08-26
申请号：EP05807224.0
申请日：2005-07-11
发明人： SMIPNOV, Leonid Dmitrievich , OSTROVSKY, Michail Arkadievich , SIPYAGIN, Aleksey Michailovich , DONCOV, Aleksandr, Evgenievich
IPC分类号： C07D213/30 , A61K31/4412 , A61P27/02 , A61P9/10
CPC分类号： C07D213/65 , C07D213/30
摘要： The invention relates to the field of medicine, namely to new biologically active compounds, particularly to 2,4,6-trimethyl-3-hydroxypiridine derivatives and salts thereof (compound 1), having antioxidant, geroprotective and anti-ischemic action. The salts of compound (1) are prepared by reacting equimolecular quantities of 2,4,6-trimethyl-3-hydroxypiridine and dicarboxylic in solution of the lower spirit at the temperature of 60-100°C with following processing of the reactionary bulk by organic solvent and incubating within 2-5 h at 10-15°C.
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公开(公告)号：EP2252265A2
公开(公告)日：2010-11-24
申请号：EP09721586.7
申请日：2009-02-19
CPC分类号： A61K31/44 , A61K9/0019
摘要： A pharmaceutically acceptable injection formulation comprising 3-hydroxy 2, 4,6 trimethylpyridine, pharmaceutically acceptable salts, esters, derivatives and polymorphs thereof for the treatment of ischemia, intraocular hemorrhage and macular degeneration is disclosed.
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公开(公告)号：EP2265252A2
公开(公告)日：2010-12-29
申请号：EP09721331.8
申请日：2009-02-19
摘要： An ophthalmic composition comprising 3-hydroxy 2,4,6 trimethylpyridine, pharmaceutically acceptable salts, esters, derivatives and polymorphs thereof for the treatment of intraocular hemorrhage and macular degeneration is disclosed.
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5.发明公开THE SUBSTANCE HAVING ANTIOXIDANT, GEROPROTECTIVE AND ANTI-ISCHEMIC ACTIVITY AND METHOD FOR PREPARING THEREOF 有权具有抗氧化物质，抗心肌缺血GEROPROTEKTIVER及作用，及其方法
公开(公告)号：EP1911746A1
公开(公告)日：2008-04-16
申请号：EP05807224.0
申请日：2005-07-11
发明人： SMIPNOV, Leonid Dmitrievich , OSTROVSKY, Michail Arkadievich , SIPYAGIN, Aleksey Michailovich , DONCOV, Aleksandr, Evgenievich
IPC分类号： C07D213/30 , A61K31/4412 , A61P27/02 , A61P9/10
CPC分类号： C07D213/65 , C07D213/30
摘要： The invention relates to the field of medicine, namely to new biologically active compounds, particularly to 2,4,6-trimethyl-3-hydroxypyridine derivatives and salts thereof (compound 1) having antioxidant, geroprotective and anti-ischemic action. The salts of compound (1) are prepared by reacting equimolecular quantities of 2,4,6-trimethyl-3-hydroxypyridine and dicarboxylic in solution of a lower alcohol at a temperature of 60-100°C with following treatment of the reaction mass with an organic solvent and maintaining for 2-5 h at 10-15 °C.
摘要翻译： 本发明涉及医学领域，即新的生物活性化合物，特别是2,4,6-三甲基-3-羟基吡啶衍生物及其盐（化合物1），其具有抗氧化，老年性保护和抗局部缺血作用。 化合物（1）的盐是通过在60-100℃的温度下与处理后的反应物料进行反应在低级醇的溶液2,4,6-三甲基-3-羟基吡啶和二羧酸的等摩尔量制备 在有机溶剂中和在10-15℃下保持2-5ħ
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