发明公开
EP1957644A2 ENZYMATIC ENCODING METHODS FOR EFFICIENT SYNTHESIS OF LARGE LIBRARIES
有权
酶介导编码方法用于大型图书馆的高效合成
- 专利标题： ENZYMATIC ENCODING METHODS FOR EFFICIENT SYNTHESIS OF LARGE LIBRARIES
- 专利标题（中）： 酶介导编码方法用于大型图书馆的高效合成
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申请号： EP06818144.5申请日： 2006-12-01
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公开(公告)号： EP1957644A2公开(公告)日： 2008-08-20
- 发明人: FRANCH, Thomas , LUNDORF, Mikkel Dybro , JAKOBSEN, Søren, Nyboe , OLSEN, Eva Kampmann , ANDERSEN, Anne Lee , HOLTMANN, Anette , HANSEN, Anders Holm , SØRENSEN, Anders Malling , GOLDBECH, Anne , DE LEON, Daen , KALDOR, Ditte Kivsmose , SLØK, Frank Abilgaard , HUSEMOEN, Gitte Nystrup , DOLBERG, Johannes , JENSEN, Kim Birkebæk , PETERSEN, Lene , NØRREGAARD-MADSEN, Mads , GODSKESEN, Michael Anders , GLAD, Sanne Schrøder , NEVE, Søren , THISTED, Thomas , KRONBORG, Tine Titilola Akinleminu , SAMS, Christian, , FELDING, Jakob , FRESKGAARD, Per-Ola , GOULIAEV, Alex Haahr , PEDERSEN, Henrik
- 申请人： Nuevolution A/S
- 申请人地址： Rønnegade 8, 5. 2100 Copenhagen 0 DK
- 专利权人： Nuevolution A/S
- 当前专利权人： Nuevolution A/S
- 当前专利权人地址： Rønnegade 8, 5. 2100 Copenhagen 0 DK
- 代理机构： HOEIBERG A/S
- 优先权： DK200501704 20051201; US741490P 20051202
- 国际公布： WO2007062664 20070607
- 主分类号： C12N15/10
- IPC分类号： C12N15/10 ; C12Q1/68 ; C40B40/06 ; C40B50/06
摘要：
Disclosed is a method for obtaining a bifunctional complex comprising a molecule linked to a single stranded identifier oligonucleotide, wherein a nascent bifunctional complex comprising a chemical reaction site and a priming site for enzymatic addition of a tag is a) reacted at the chemical reaction site with one or more reactants, and b) reacted enzymatically at the priming site with one or more tag(s) identifying the reactant(s).
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