发明公开
- 专利标题： SOLUBLE STABILIZED TRIMERIC HIV ENV PROTEINS AND USES THEREOF
- 专利标题（中）： 可溶性稳定化三聚HIV包膜蛋白，和使用
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申请号： EP07809721.9申请日： 2007-06-19
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公开(公告)号： EP2040747A2公开(公告)日： 2009-04-01
- 发明人: OLSON, William C. , MADDON, Paul J. , FRANTI, Michael , IYER, Sai Prasad N. , ANDJELIC, Sofija , MOORE, John P. , BEDDOWS, Simon
- 申请人： Progenics Pharmaceuticals, Inc. , Cornell Research Foundation, Inc.
- 申请人地址： 777 Old Saw Mill River Road Tarrytown, NY 10591 US
- 专利权人： Progenics Pharmaceuticals, Inc.,Cornell Research Foundation, Inc.
- 当前专利权人： Progenics Pharmaceuticals, Inc.,Cornell Research Foundation, Inc.
- 当前专利权人地址： 777 Old Saw Mill River Road Tarrytown, NY 10591 US
- 代理机构： Müller Fottner Steinecke
- 优先权： US815233P 20060619; US815248P 20060619
- 国际公布： WO2007149491 20071227
- 主分类号： A61K39/21
- IPC分类号： A61K39/21 ; A61K39/12
摘要：
This invention provides a protein comprising (a) a first polypeptide which comprises consecutive amino acids, the sequence of which corresponds to the sequence of a modified gpl20 envelope polypeptide portion of a gpl40 envelope of (i) an HIV-I KNH1144 isolate, or a quasi-species thereof, or (ii) an HIV-I 5768.4 isolate, or a quasi-species thereof; and (b) a second polypeptide which comprises consecutive amino acids, the sequence of which corresponds to the sequence of a modified gp41 ectodomain polypeptide portion of the gpl40 envelope of (i) the HIV-I KNHl144 isolate or such quasi-species thereof, or (ii) the HIV-I 5768.4 isolate or such quasi-species thereof. This invention also provides nucleic acids encoding such proteins, vectors, host cells and compositions thereof. Also provided are trimeric complexes ('trimers') of these proteins and methods of using such trimers to combat HIV-I infection.
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