公开(公告)号：EP2040747A2

公开(公告)日：2009-04-01

申请号：EP07809721.9

申请日：2007-06-19

申请人： Progenics Pharmaceuticals, Inc. ,  Cornell Research Foundation, Inc.

发明人： OLSON, William C. ,  MADDON, Paul J. ,  FRANTI, Michael ,  IYER, Sai Prasad N. ,  ANDJELIC, Sofija ,  MOORE, John P. ,  BEDDOWS, Simon

IPC分类号： A61K39/21 ,  A61K39/12

CPC分类号： C07K16/1063 ,  A61K39/00 ,  A61K2039/55566 ,  A61K2039/55577 ,  C07K14/005 ,  C07K2317/76 ,  C12N2740/16122

摘要： This invention provides a protein comprising (a) a first polypeptide which comprises consecutive amino acids, the sequence of which corresponds to the sequence of a modified gpl20 envelope polypeptide portion of a gpl40 envelope of (i) an HIV-I KNH1144 isolate, or a quasi-species thereof, or (ii) an HIV-I 5768.4 isolate, or a quasi-species thereof; and (b) a second polypeptide which comprises consecutive amino acids, the sequence of which corresponds to the sequence of a modified gp41 ectodomain polypeptide portion of the gpl40 envelope of (i) the HIV-I KNHl144 isolate or such quasi-species thereof, or (ii) the HIV-I 5768.4 isolate or such quasi-species thereof. This invention also provides nucleic acids encoding such proteins, vectors, host cells and compositions thereof. Also provided are trimeric complexes ('trimers') of these proteins and methods of using such trimers to combat HIV-I infection.