发明公开
- 专利标题： RECOMBINANT BCG TUBERCULOSIS VACCINE FOR ELICITING IMMUNE RESPONSES TO MYCOBACTERIUM TUBERCULOSIS
- 专利标题（中）： 重组卡介苗对结核病诱导免疫反应对结核分枝杆菌的
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申请号： EP08853526.5申请日： 2008-11-26
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公开(公告)号： EP2235163A1公开(公告)日： 2010-10-06
- 发明人: SHAFFERMAN, Avigdor , ZVI, Anat , ARIEL, Naomi , FULKERSON, John , SUN, Ronggai , CHANG, Rosemary , SADOFF, Jerald, C.
- 申请人： Aeras Global TB Vaccine Foundation
- 申请人地址： 1405 Research Boulevard, Suite 300 Rockville, MD 20850 US
- 专利权人： Aeras Global TB Vaccine Foundation
- 当前专利权人： Aeras Global TB Vaccine Foundation
- 当前专利权人地址： 1405 Research Boulevard, Suite 300 Rockville, MD 20850 US
- 代理机构： Kröncke, Rolf
- 优先权： US945680 20071127
- 国际公布： WO2009070700 20090604
- 主分类号： C12N7/00
- IPC分类号： C12N7/00 ; A61K39/00
摘要：
A vaccine against Mycobacteria tuberculosis (Mtb) is provided. The vaccine comprises a recombinant Bacille Calmette-Guerin (BCG) subunit-based vaccine in which one or more Mtb antigens and one or more Mtb resuscitation or reactivation antigens are overexpressed, and in which at least a portion of the DosR regulon is up-regulated. The vaccine is protective against active Mtb infection both pre- and post-exposure to Mtb, and thus prevents disease symptoms due to the recurrence of a latent Mtb infection.
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