发明公开
EP2246054A1 FENTANYL-CONTAINING PATCH FOR EXTERNAL USE
有权
FENTANYLHALTIGES PFLASTER ZURÄUSSERLICHENANWENDUNG
- 专利标题: FENTANYL-CONTAINING PATCH FOR EXTERNAL USE
- 专利标题(中): FENTANYLHALTIGES PFLASTER ZURÄUSSERLICHENANWENDUNG
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申请号: EP09706430.7申请日: 2009-01-26
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公开(公告)号: EP2246054A1公开(公告)日: 2010-11-03
- 发明人: MATSUSHITA, Kunihiko , NARUSE, Mamoru , HATTORI, Kenichi
- 申请人: TEIKOKU SEIYAKU CO., LTD.
- 申请人地址: 567, Sanbonmatsu Higashikagawa-shi, Kagawa 769-2695 JP
- 专利权人: TEIKOKU SEIYAKU CO., LTD.
- 当前专利权人: TEIKOKU SEIYAKU CO., LTD.
- 当前专利权人地址: 567, Sanbonmatsu Higashikagawa-shi, Kagawa 769-2695 JP
- 代理机构: Albrecht, Thomas
- 优先权: JP2008015875 20080128
- 国际公布: WO2009096354 20090806
- 主分类号: A61K31/4468
- IPC分类号: A61K31/4468 ; A61K9/70 ; A61K47/14 ; A61K47/32 ; A61K47/46 ; A61P25/04
摘要:
A patch for external use which has a laminate structure comprising a substrate and a pressure-sensitive adhesive layer which contains a styrene/isoprene/styrene block copolymer as the base and further contains a tackifier resin consisting of a rosin resin and at least one other tackifier resin, a softening agent consisting of polybutene and liquid paraffin, a fatty acid ester, and fentanyl, characterized in that the weight ratio of the rosin resin to fentanyl is 1 to 5, the weight ratio of the rosin resin to the whole tackifier resin is 0.1 to 0.6, and the tackifier resin accounts for 30 to 60wt% of the whole pressure-sensitive adhesive layer. The patch is excellent in the permeation of fentanyl through the skin and in storage stability, and is weak in irritation to skin.
公开/授权文献
- EP2246054B1 FENTANYL-CONTAINING PATCH FOR EXTERNAL USE 公开/授权日:2018-06-13
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