公开(公告)号：EP2246054B1

公开(公告)日：2018-06-13

申请号：EP09706430.7

申请日：2009-01-26

申请人： TEIKOKU SEIYAKU CO., LTD.

发明人： MATSUSHITA, Kunihiko ,  NARUSE, Mamoru ,  HATTORI, Kenichi

IPC分类号： A61K31/4468 ,  A61K9/70 ,  A61P25/04

CPC分类号： A61K9/7076 ,  A61K9/0014 ,  A61K9/7023 ,  A61K9/7053 ,  A61K31/4468 ,  A61K47/06 ,  A61K47/14 ,  A61K47/32

摘要： A patch for external use which has a laminate structure comprising a substrate and a pressure-sensitive adhesive layer which contains a styrene/isoprene/styrene block copolymer as the base and further contains a tackifier resin consisting of a rosin resin and at least one other tackifier resin, a softening agent consisting of polybutene and liquid paraffin, a fatty acid ester, and fentanyl, characterized in that the weight ratio of the rosin resin to fentanyl is 1 to 5, the weight ratio of the rosin resin to the whole tackifier resin is 0.1 to 0.6, and the tackifier resin accounts for 30 to 60wt% of the whole pressure-sensitive adhesive layer. The patch is excellent in the permeation of fentanyl through the skin and in storage stability, and is weak in irritation to skin.

公开(公告)号：EP1970076A1

公开(公告)日：2008-09-17

申请号：EP06843226.9

申请日：2006-12-26

申请人： TEIKOKU SEIYAKU CO., LTD. ,  NIHON NOHYAKU CO., LTD.

发明人： ISHIMA, Tomohiro ,  NARUSE, Mamoru ,  KANEDA, Hideo ,  KANAI, Kazuo ,  SEKINE, Takashi ,  OOTA, Shinichi ,  YOSHIMURA, Tomonari

IPC分类号： A61K47/22 ,  A61K9/70 ,  A61K31/4178 ,  A61K45/00 ,  A61K47/10 ,  A61K47/32 ,  A61K47/34 ,  A61K47/36 ,  A61K47/38 ,  A61K47/42 ,  A61P17/00 ,  A61P31/10

CPC分类号： A61K9/7061 ,  A61F13/02 ,  A61F13/105 ,  A61F2013/00906 ,  A61K9/0014 ,  A61K31/00 ,  A61K31/4174 ,  A61K31/4178 ,  A61K45/06 ,  A61K47/10 ,  A61K47/22 ,  A61K47/32 ,  A61K47/38 ,  A61M35/00

摘要： Since treatment effects of conventional external preparations were not satisfactory, it is aimed to provide a novel external preparation that is excellent in drug permeability to nail, capable of fully exhibiting effects of an antifungal drug, and effective for treatments of diseases such as nail mycosis and nail candidiasis, particularly, treatments for nail tinea. The external preparation of this invention is a pharmaceutical composition for nail characterized by containing an antifungal drug, alkylpyrrolidone or a derivative thereof, and a crosslinking hydrogel.

摘要翻译： 由于常规外用制剂的治疗效果不能令人满意，目的在于提供一种能够充分发挥抗真菌药物效果的指甲药物渗透性优异的新型外用制剂，对于治疗诸如甲型真菌病等疾病有效。 指甲念珠菌病，特别是指甲癣的治疗。 本发明的外用制剂是用于指甲的药物组合物，其特征在于含有抗真菌药，烷基吡咯烷酮或其衍生物和交联水凝胶。

公开(公告)号：EP2246054A1

公开(公告)日：2010-11-03

申请号：EP09706430.7

申请日：2009-01-26

申请人： TEIKOKU SEIYAKU CO., LTD.

发明人： MATSUSHITA, Kunihiko ,  NARUSE, Mamoru ,  HATTORI, Kenichi

IPC分类号： A61K31/4468 ,  A61K9/70 ,  A61K47/14 ,  A61K47/32 ,  A61K47/46 ,  A61P25/04

CPC分类号： A61K9/7076 ,  A61K9/0014 ,  A61K9/7023 ,  A61K9/7053 ,  A61K31/4468 ,  A61K47/06 ,  A61K47/14 ,  A61K47/32

摘要： A patch for external use which has a laminate structure comprising a substrate and a pressure-sensitive adhesive layer which contains a styrene/isoprene/styrene block copolymer as the base and further contains a tackifier resin consisting of a rosin resin and at least one other tackifier resin, a softening agent consisting of polybutene and liquid paraffin, a fatty acid ester, and fentanyl, characterized in that the weight ratio of the rosin resin to fentanyl is 1 to 5, the weight ratio of the rosin resin to the whole tackifier resin is 0.1 to 0.6, and the tackifier resin accounts for 30 to 60wt% of the whole pressure-sensitive adhesive layer. The patch is excellent in the permeation of fentanyl through the skin and in storage stability, and is weak in irritation to skin.

摘要翻译： 一种外用贴剂，其具有包含基材和粘合剂层的层叠结构，所述粘合剂层含有苯乙烯/异戊二烯/苯乙烯嵌段共聚物作为基材，并且还含有由松香树脂和至少一种其它增粘剂组成的增粘树脂 树脂，由聚丁烯和液体石蜡组成的软化剂，脂肪酸酯和芬太尼，其特征在于松香树脂与芬太尼的重量比为1〜5，松香树脂与全部增粘树脂的重量比为 0.1〜0.6，增粘树脂占整个压敏粘合剂层的30〜60重量％。 芬太尼通过皮肤渗透和保存稳定性优异，并且对皮肤的刺激性弱。

公开(公告)号：EP2457570B1

公开(公告)日：2018-08-22

申请号：EP10802265.8

申请日：2010-07-21

申请人： Teikoku Seiyaku Co., Ltd.

发明人： NARUSE, Mamoru ,  HATTORI, Kenichi ,  MATSUSHITA, Kunihiko

IPC分类号： A61K31/4468 ,  A61K9/70 ,  A61K47/06 ,  A61K47/14 ,  A61K47/32

CPC分类号： A61K9/7076 ,  A61K9/7053 ,  A61K31/4468

摘要： Disclosed is a fentanyl-containing adhesive preparation for external use, wherein an adhesive layer is laminated on a supporting body. The adhesive layer contains SIS, a tackifier resin that is composed of a rosin resin and terpene resin, and a softener that is composed of a plybutene and a liquid paraffin. The adhesive layer also contains fentanyl as an active ingredient. The fentanyl-containing adhesive preparation for external use has excellent skin permeation of fentanyl and high preparation stability, without suffering from crystallization of fentanyl during storage.

公开(公告)号：EP2457570A1

公开(公告)日：2012-05-30

申请号：EP10802265.8

申请日：2010-07-21

申请人： Teikoku Seiyaku Co., Ltd.

发明人： NARUSE, Mamoru ,  HATTORI, Kenichi ,  MATSUSHITA, Kunihiko

IPC分类号： A61K31/4468 ,  A61K9/70 ,  A61K47/06 ,  A61K47/14 ,  A61K47/32

CPC分类号： A61K9/7076 ,  A61K9/7053 ,  A61K31/4468

摘要： Disclosed is a fentanyl-containing adhesive preparation for external use, wherein an adhesive layer is laminated on a supporting body. The adhesive layer contains SIS, a tackifier resin that is composed of a rosin resin and terpene resin, and a softener that is composed of a plybutene and a liquid paraffin. The adhesive layer also contains fentanyl as an active ingredient. The fentanyl-containing adhesive preparation for external use has excellent skin permeation of fentanyl and high preparation stability, without suffering from crystallization of fentanyl during storage.

摘要翻译： 公开了一种用于外用的含芬太尼的粘合剂，其中粘合剂层层压在支撑体上。 粘合剂层含有SIS，由松香树脂和萜烯树脂构成的增粘树脂，以及由聚烯丙烯和液体石蜡组成的软化剂。 粘合剂层还含有芬太尼作为活性成分。 用于外用的含芬太尼的粘合剂具有优异的芬太尼皮肤渗透性和高的制剂稳定性，而在保存期间不会结晶芬太尼。

公开(公告)号：EP1557164A1

公开(公告)日：2005-07-27

申请号：EP04746246.0

申请日：2004-06-16

申请人： Teikoku Seiyaku Co., Ltd.

发明人： SHIRAI, Sadanobu ,  YAMAJI, Masahiro ,  YOSHIMOTO, Osamu ,  NARUSE, Mamoru ,  HATTORI, Kenichi ,  SUEDA, Takako, 101, Morimoto-No.5 building

IPC分类号： A61K31/137 ,  A61K47/12 ,  A61K47/32 ,  A61K9/70 ,  A61P11/08

CPC分类号： A61K9/7053 ,  A61K9/7076 ,  A61K31/137 ,  A61K47/12

摘要： A patch containing tulobuterol in the low concentration and having the stable release-controllability, prepared by laminating an adhesive layer consisting of a rubber, an adhesive resin and a plasticizer on a backing, wherein 1 to 4 w/w % of tulobuterol in the lower concentration as an active ingredient and 0.1 to 3 w/w % of a higher fatty acid as a drug-releasing controlling agent are contained in the adhesive layer.

摘要翻译： 通过将由橡胶，粘合剂树脂和增塑剂组成的粘合剂层层压在背衬上制备的含有低浓度的杜洛特罗并具有稳定的释放控制性的贴剂，其中在下部的1至4w / w％的十四氟醇 作为活性成分的浓度和作为药物释放控制剂的0.1〜3w / w％的高级脂肪酸被包含在粘合剂层中。