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11 条记录 (耗时 0.015 秒)

    FENTANYL-CONTAINING PATCH FOR EXTERNAL USE
    5.
    发明公开
    FENTANYL-CONTAINING PATCH FOR EXTERNAL USE 有权
    FENTANYLHALTIGES PFLASTER ZURÄUSSERLICHENANWENDUNG

    公开(公告)号：EP2246054A1

    公开(公告)日：2010-11-03

    申请号：EP09706430.7

    申请日：2009-01-26

    申请人： TEIKOKU SEIYAKU CO., LTD.

    发明人： MATSUSHITA, Kunihiko ,  NARUSE, Mamoru ,  HATTORI, Kenichi

    IPC分类号： A61K31/4468 ,  A61K9/70 ,  A61K47/14 ,  A61K47/32 ,  A61K47/46 ,  A61P25/04

    CPC分类号： A61K9/7076 ,  A61K9/0014 ,  A61K9/7023 ,  A61K9/7053 ,  A61K31/4468 ,  A61K47/06 ,  A61K47/14 ,  A61K47/32

    摘要： A patch for external use which has a laminate structure comprising a substrate and a pressure-sensitive adhesive layer which contains a styrene/isoprene/styrene block copolymer as the base and further contains a tackifier resin consisting of a rosin resin and at least one other tackifier resin, a softening agent consisting of polybutene and liquid paraffin, a fatty acid ester, and fentanyl, characterized in that the weight ratio of the rosin resin to fentanyl is 1 to 5, the weight ratio of the rosin resin to the whole tackifier resin is 0.1 to 0.6, and the tackifier resin accounts for 30 to 60wt% of the whole pressure-sensitive adhesive layer. The patch is excellent in the permeation of fentanyl through the skin and in storage stability, and is weak in irritation to skin.

    摘要翻译： 一种外用贴剂，其具有包含基材和粘合剂层的层叠结构，所述粘合剂层含有苯乙烯/异戊二烯/苯乙烯嵌段共聚物作为基材，并且还含有由松香树脂和至少一种其它增粘剂组成的增粘树脂 树脂，由聚丁烯和液体石蜡组成的软化剂，脂肪酸酯和芬太尼，其特征在于松香树脂与芬太尼的重量比为1〜5，松香树脂与全部增粘树脂的重量比为 0.1〜0.6，增粘树脂占整个压敏粘合剂层的30〜60重量％。 芬太尼通过皮肤渗透和保存稳定性优异，并且对皮肤的刺激性弱。

    EXTERNAL PATCH CONTAINING ESTROGEN AND/OR PROGESTOGEN
    6.
    发明公开
    EXTERNAL PATCH CONTAINING ESTROGEN AND/OR PROGESTOGEN 有权
    外部PFLASTER MITÖSTROGENUND / ODER GESTAGEN

    公开(公告)号：EP1623711A1

    公开(公告)日：2006-02-08

    申请号：EP04732726.7

    申请日：2004-05-13

    申请人： TEIKOKU SEIYAKU CO., LTD. ,  FUSO PHARMACEUTICAL INDUSTRIES LTD.

    发明人： MATSUSHITA, Kunihiko ,  HATTORI, Kenichi ,  YAMAJI, Masahiro

    IPC分类号： A61K31/565 ,  A61K31/57 ,  A61K9/70 ,  A61P3/06 ,  A61P5/30 ,  A61P9/10 ,  A61P15/12 ,  A61P19/10 ,  A61P25/28 ,  A61P29/00

    CPC分类号： A61K9/7053 ,  A61K9/7076 ,  A61K31/565 ,  A61K31/57 ,  A61L15/585 ,  A61K2300/00 ,  C08L39/06 ,  C08L53/02

    摘要： An external patch capable of stable prolonged release and transdemtal absorption of active ingredient hormones (estrogens and/or progestogens) contained in a pressure sensitive adhesive layer, which external patch ensures low irritation on the skin. In particular, an external patch comprising a support and, superimposed thereon, a pressure sensitive adhesive layer, characterized in that the pressure sensitive adhesive layer comprises, as indispensable components, 5 to 50 wt.% of styrene/isoprene/styrene block copolymer, 20 to 70 wt.% of tackifier resin, 10 to 60 wt.% of softener and 1 to 20 wt.% of polyvinylpyrrolidone and contains, as an active ingredient, estrogen and/or progestogen.

    摘要翻译： 包含在压敏粘合剂层中的活性成分激素（雌激素和/或孕激素）的稳定的延长释放和透过吸收的外部贴剂，该外部贴片确保对皮肤的低刺激性。 特别地，包括支撑体并且叠加在其上的压敏粘合剂层的外部贴片，其特征在于，所述压敏粘合剂层包含5至50重量％的苯乙烯/异戊二烯/苯乙烯嵌段共聚物，20重量％ 至70重量％的增粘树脂，10至60重量％的软化剂和1至20重量％的聚乙烯吡咯烷酮，并且含有作为活性成分的雌激素和/或孕激素。

    TOLTERODINE-CONTAINING ADHESIVE PATCH
    8.
    发明公开
    TOLTERODINE-CONTAINING ADHESIVE PATCH 审中-公开
    毒死蜱

    公开(公告)号：EP2799066A1

    公开(公告)日：2014-11-05

    申请号：EP12861215.7

    申请日：2012-12-25

    申请人： TEIKOKU SEIYAKU CO., LTD.

    发明人： SHIBATA, Taiki ,  MURATA, Kensuke ,  HATTORI, Kenichi ,  TANAKA, Shinji

    IPC分类号： A61K31/137 ,  A61K9/70 ,  A61K47/32

    CPC分类号： A61K31/137 ,  A61K9/7053 ,  A61K31/70 ,  A61K31/7076 ,  A61K31/7084

    摘要： The present invention provides a tolterodine-containing patch in which an adhesive layer is laminated on a backing, characterized in that the adhesive layer is obtainable by adding tolterodine to an adhesive base comprising a rubber adhesive, a tackifier resin, and a softener, wherein the tolterodine is present in the form of a free base in the adhesive base.

    摘要翻译： 本发明提供了含有托特罗定的贴剂，其中粘合剂层层压在背衬上，其特征在于，通过向包含橡胶粘合剂，增粘树脂和软化剂的粘合剂基底添加托特罗定可获得粘合剂层，其中 托特罗定以粘合剂基质中游离碱的形式存在。

    ANTI-INFLAMMATORY ANALGESIC ADHESIVE PATCH FOR EXTERNAL USE
    9.
    发明公开
    ANTI-INFLAMMATORY ANALGESIC ADHESIVE PATCH FOR EXTERNAL USE 有权
    ENTZÜNDUNGSHEMMENDESUND SCHMERZSTILLESES HEFTPFLASTER ZUR EXTERNEN ANWENDUNG

    公开(公告)号：EP2524692A1

    公开(公告)日：2012-11-21

    申请号：EP11731785.9

    申请日：2011-01-05

    申请人： Teikoku Seiyaku Co., Ltd. ,  Ibsa Institut Biochimique S.A.

    发明人： SHIBATA, Taiki ,  MABUCHI, Yuichiro ,  HATTORI, Kenichi ,  KAMAKURA, Takashi

    IPC分类号： A61K31/40 ,  A61K9/70 ,  A61K47/10 ,  A61K47/20 ,  A61K47/22 ,  A61K47/32

    CPC分类号： A61K31/40 ,  A61K9/7053 ,  A61K9/7076 ,  A61K31/196 ,  Y10T156/10 ,  A61K2300/00

    摘要： An external patch containing diclofenac hydroxyethylpyrrolidine prepared by laminating an adhesive layer on a backing, wherein said adhesive layer is characterized by comprising 5-50% by weight of styrene·isoprene·styrene block copolymer, 20-50% by weight of a tackifier resin, 5-70% by weight of a softening agent, and 0.5-20% by weight of one or more solubilizers selected from N-methyl-2-pyrrolidone, propylene glycol and dimethyl sulfoxide as essential ingredients, and 0.5-20% by weight of diclofenac hydroxyethylpyrrolidine as an active ingredient. The patch has excellent transdermal absorption, less skin-irritation and excellent stability of the drug.

    摘要翻译： 通过将粘合剂层层压在背衬上制备的含有双氯芬酸羟乙基吡咯烷的外部贴片，其中所述粘合剂层的特征在于包含5-50重量％的苯乙烯·异戊二烯·苯乙烯嵌段共聚物，20-50重量％的增粘树脂， 5-70重量％的软化剂和0.5-20重量％的一种或多种选自N-甲基-2-吡咯烷酮，丙二醇和二甲基亚砜作为必需成分的增溶剂，和0.5-20重量％ 双氯芬酸羟乙基吡咯烷作为活性成分。 该贴剂具有优异的透皮吸收，较少的皮肤刺激和优异的药物稳定性。

    FENTANYL-CONTAINING ADHESIVE PREPARATION FOR EXTERNAL USE
    10.
    发明公开
    FENTANYL-CONTAINING ADHESIVE PREPARATION FOR EXTERNAL USE 审中-公开
    FENTANYLHALTIGESHAFTPRÄPARATZURÄUSSERENANWENDUNG

    公开(公告)号：EP2457570A1

    公开(公告)日：2012-05-30

    申请号：EP10802265.8

    申请日：2010-07-21

    申请人： Teikoku Seiyaku Co., Ltd.

    发明人： NARUSE, Mamoru ,  HATTORI, Kenichi ,  MATSUSHITA, Kunihiko

    IPC分类号： A61K31/4468 ,  A61K9/70 ,  A61K47/06 ,  A61K47/14 ,  A61K47/32

    CPC分类号： A61K9/7076 ,  A61K9/7053 ,  A61K31/4468

    摘要： Disclosed is a fentanyl-containing adhesive preparation for external use, wherein an adhesive layer is laminated on a supporting body. The adhesive layer contains SIS, a tackifier resin that is composed of a rosin resin and terpene resin, and a softener that is composed of a plybutene and a liquid paraffin. The adhesive layer also contains fentanyl as an active ingredient. The fentanyl-containing adhesive preparation for external use has excellent skin permeation of fentanyl and high preparation stability, without suffering from crystallization of fentanyl during storage.

    摘要翻译： 公开了一种用于外用的含芬太尼的粘合剂，其中粘合剂层层压在支撑体上。 粘合剂层含有SIS，由松香树脂和萜烯树脂构成的增粘树脂，以及由聚烯丙烯和液体石蜡组成的软化剂。 粘合剂层还含有芬太尼作为活性成分。 用于外用的含芬太尼的粘合剂具有优异的芬太尼皮肤渗透性和高的制剂稳定性，而在保存期间不会结晶芬太尼。