发明公开
- 专利标题： GAMMA SECRETASE MODULATORS
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申请号： EP09752609.9申请日： 2009-11-05
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公开(公告)号： EP2356115A1公开(公告)日： 2011-08-17
- 发明人: ZHU, Zhaoning , GREENLEE, William, J. , COLE, David, James , PISSARNITSKI, Dmitri, A. , GALLO, Gioconda, V. , LI, Hongmei , JOSIEN, Hubert, B. , QIN, Jun , KNUTSON, Chad, E. , MANDAL, Mihirbaran , VICAREL, Monica, L. , RAJAGOPALAN, Murali , DHONDI, Pawan, Kumar , XU, Ruo , SUN, Zhong-Yue , BARA, Thomas, A. , HUANG, Xianhai , ZHU, Xiaohong , ZHAO, Zhiqiang , CLADER, John, W. , PALANI, Anandan , ASBEROM, Theodros , MCCRACKEN, Troy , BENNETT, Chad, E.
- 申请人： Schering Corporation
- 申请人地址： 126 East Lincoln Avenue, RY60-30 Rahway, NJ 07065 US
- 专利权人： Schering Corporation
- 当前专利权人： Schering Corporation
- 当前专利权人地址： 126 East Lincoln Avenue, RY60-30 Rahway, NJ 07065 US
- 代理机构： Buchan, Gavin MacNicol
- 优先权： US111829P 20081106
- 国际公布： WO2010054078 20100514
- 主分类号： C07D413/10
- IPC分类号： C07D413/10 ; C07D471/04 ; C07D498/04 ; C07D498/20 ; A61K31/4245 ; A61K31/4162 ; A61P25/28
摘要：
In its many embodiments, the present invention provides novel heterocyclic compounds as modulators of gamma secretase, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the central nervous system using such compounds or pharmaceutical compositions.
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