公开(公告)号：EP2352731A1

公开(公告)日：2011-08-10

申请号：EP09753287.3

申请日：2009-11-05

申请人： Schering Corporation

发明人： ZHU, Zhaoning ,  GREENLEE, William, J. ,  GALLO, Gioconda, V. ,  LI, Hongmei ,  MANDAL, Mihirbaran ,  MCCRACKEN, Troy ,  BENNETT, Chad, E. ,  BURNETT, Duane, A

IPC分类号： C07D403/10 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D491/20 ,  C07D498/04 ,  C07D498/20 ,  C07D513/04 ,  C07F7/10 ,  A61K31/53 ,  A61P25/28

CPC分类号： C07D471/04 ,  C07D413/10 ,  C07D498/04 ,  C07D498/20 ,  C07F7/0812

摘要： In its many embodiments, the present invention provides a novel class of heterocyclic compounds of the formula: as modulators of gamma secretase, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the central nervous system using such compounds or pharmaceutical compositions.

公开(公告)号：EP2356115A1

公开(公告)日：2011-08-17

申请号：EP09752609.9

申请日：2009-11-05

申请人： Schering Corporation

发明人： ZHU, Zhaoning ,  GREENLEE, William, J. ,  COLE, David, James ,  PISSARNITSKI, Dmitri, A. ,  GALLO, Gioconda, V. ,  LI, Hongmei ,  JOSIEN, Hubert, B. ,  QIN, Jun ,  KNUTSON, Chad, E. ,  MANDAL, Mihirbaran ,  VICAREL, Monica, L. ,  RAJAGOPALAN, Murali ,  DHONDI, Pawan, Kumar ,  XU, Ruo ,  SUN, Zhong-Yue ,  BARA, Thomas, A. ,  HUANG, Xianhai ,  ZHU, Xiaohong ,  ZHAO, Zhiqiang ,  CLADER, John, W. ,  PALANI, Anandan ,  ASBEROM, Theodros ,  MCCRACKEN, Troy ,  BENNETT, Chad, E.

IPC分类号： C07D413/10 ,  C07D471/04 ,  C07D498/04 ,  C07D498/20 ,  A61K31/4245 ,  A61K31/4162 ,  A61P25/28

CPC分类号： C07D471/04 ,  C07D413/10 ,  C07D498/04 ,  C07D498/20 ,  C07F7/0812

摘要： In its many embodiments, the present invention provides novel heterocyclic compounds as modulators of gamma secretase, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the central nervous system using such compounds or pharmaceutical compositions.

摘要翻译： 在其许多实施方案中，本发明提供了作为γ分泌酶调节剂的新型杂环化合物，制备此类化合物的方法，含有一种或多种此类化合物的药物组合物，制备包含一种或多种此类化合物的药物制剂的方法，以及治疗， 使用这些化合物或药物组合物预防，抑制或改善与中枢神经系统相关的一种或多种疾病。

公开(公告)号：EP2229381A1

公开(公告)日：2010-09-22

申请号：EP08856462.0

申请日：2008-12-04

申请人： Schering Corporation

发明人： HUANG, Xianhai ,  PALANI, Anandan ,  QIN, Jun ,  ASLANIAN, Robert, G. ,  ZHU, Zhaoning ,  GREENLEE, William, J. ,  JOSIEN, Hubert ,  ZHOU, Wei ,  ZHU, Xiaohong ,  BENNETT, Chad, E. ,  PISSARNITSKI, Dmitri ,  MANDAL, Mihirbaran ,  DHONDI, Pawan ,  MCCRACKEN, Troy ,  BARA, Thomas ,  ZHAO, Zhiqiang ,  BURNETT, Duane ,  CLADER, John

IPC分类号： C07D403/10 ,  C07D471/04 ,  C07D487/04 ,  C07D498/04 ,  C07D513/04 ,  A61K31/4738 ,  A61P25/28

CPC分类号： C07D471/04 ,  C07D403/10 ,  C07D487/04 ,  C07D498/04 ,  C07D513/04

摘要： This invention provides novel compounds that are modulators of gamma secretase. The compounds have the formula (I) wherein R2 is a fused bicyclic ring of the formula (II). Also disclosed are methods of modulating gamma secretase activity and methods of treating Alzheimer's disease using the compounds of formula (I).

摘要翻译： 本发明提供了γ分泌酶调节剂的新化合物。 该化合物具有式（I），其中R 2是式（II）的稠合双环。 还公开了使用式（I）化合物调节γ分泌酶活性的方法和治疗阿尔茨海默病的方法。