公开(公告)号：EP2356115A1

公开(公告)日：2011-08-17

申请号：EP09752609.9

申请日：2009-11-05

申请人： Schering Corporation

发明人： ZHU, Zhaoning ,  GREENLEE, William, J. ,  COLE, David, James ,  PISSARNITSKI, Dmitri, A. ,  GALLO, Gioconda, V. ,  LI, Hongmei ,  JOSIEN, Hubert, B. ,  QIN, Jun ,  KNUTSON, Chad, E. ,  MANDAL, Mihirbaran ,  VICAREL, Monica, L. ,  RAJAGOPALAN, Murali ,  DHONDI, Pawan, Kumar ,  XU, Ruo ,  SUN, Zhong-Yue ,  BARA, Thomas, A. ,  HUANG, Xianhai ,  ZHU, Xiaohong ,  ZHAO, Zhiqiang ,  CLADER, John, W. ,  PALANI, Anandan ,  ASBEROM, Theodros ,  MCCRACKEN, Troy ,  BENNETT, Chad, E.

IPC分类号： C07D413/10 ,  C07D471/04 ,  C07D498/04 ,  C07D498/20 ,  A61K31/4245 ,  A61K31/4162 ,  A61P25/28

CPC分类号： C07D471/04 ,  C07D413/10 ,  C07D498/04 ,  C07D498/20 ,  C07F7/0812

摘要： In its many embodiments, the present invention provides novel heterocyclic compounds as modulators of gamma secretase, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the central nervous system using such compounds or pharmaceutical compositions.

摘要翻译： 在其许多实施方案中，本发明提供了作为γ分泌酶调节剂的新型杂环化合物，制备此类化合物的方法，含有一种或多种此类化合物的药物组合物，制备包含一种或多种此类化合物的药物制剂的方法，以及治疗， 使用这些化合物或药物组合物预防，抑制或改善与中枢神经系统相关的一种或多种疾病。

公开(公告)号：EP1976843A2

公开(公告)日：2008-10-08

申请号：EP07716750.0

申请日：2007-01-18

申请人： Schering Corporation

发明人： ASBEROM, Theodros ,  BARA, Thomas ,  BENNETT, Chad, E. ,  BURNETT, Duane, A. ,  CAPLEN, Mary Ann ,  CLADER, John, W. ,  COLE, David, J. ,  DOMALSKI, Martin, S. ,  JOSIEN, Hubert, B. ,  KNUTSON, Chad, E. ,  LI, Hongmei ,  MCBRIAR, Mark, D. ,  PISSARNITSKI, Dmitri, A. ,  QIANG, Li ,  RAJAGOPALAN, Murali ,  SASIKUMAR, Thavalakulamgar, K. ,  SU, Jing ,  TANG, Haiqun ,  WU, Wen-Lian ,  XU, Ruo ,  ZHAO, Zhiqiang

IPC分类号： C07D311/22 ,  C07D311/80 ,  C07D311/92 ,  C07D311/94 ,  C07D313/08 ,  C07D335/06

CPC分类号： C07D311/22 ,  C07C317/14 ,  C07C317/20 ,  C07C317/44 ,  C07C2602/08 ,  C07C2602/10 ,  C07C2602/12 ,  C07D311/80 ,  C07D311/92 ,  C07D311/94 ,  C07D313/08 ,  C07D335/06 ,  C07D405/12 ,  C07D409/12 ,  C07D491/04 ,  C07D493/04

摘要： This invention discloses novel gamma secretase inhibitors of the formula: R2 and R3, or R2 and R4, or R3 and R4, together with the atoms to which they are bound, can form a fused cycloalkyl or fused heterocycloalkyl ring. The cycloalkyl ring or the heterocycloalkyl ring can be optionally substituted with one or more substituents. One or more compounds of formula (I), or formulations comprising such compounds, may be useful, e.g. in treating Alzheimer's Disease.