发明公开
EP2361624A1 Oxazole derivatives and their use as tyrosine kinase inhibitors
审中-公开
Oxazolderivate和Ihre Anwendung als Tyrosinkinase Inhibitoren
- 专利标题： Oxazole derivatives and their use as tyrosine kinase inhibitors
- 专利标题（中）： Oxazolderivate和Ihre Anwendung als Tyrosinkinase Inhibitoren
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申请号： EP11160069.8申请日： 2006-04-04
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公开(公告)号： EP2361624A1公开(公告)日： 2011-08-31
- 发明人: Grierson, David , Benjahad, Abdellah , Moussy, Alain , Croisy, Martine
- 申请人： AB Science , Centre National de la Recherche Scientifique (CNRS) , Institut Curie
- 申请人地址： 3, avenue George V 75008 Paris FR
- 专利权人： AB Science,Centre National de la Recherche Scientifique (CNRS),Institut Curie
- 当前专利权人： AB Science,Centre National de la Recherche Scientifique (CNRS),Institut Curie
- 当前专利权人地址： 3, avenue George V 75008 Paris FR
- 代理机构： Warcoin, Jacques
- 优先权： US667771P 20050404
- 主分类号： A61K31/421
- IPC分类号： A61K31/421 ; A61K31/427 ; A61K31/4439 ; C07D263/48 ; C07D413/04 ; C07D413/12 ; C07D413/14 ; C07D417/12 ; A61P29/00 ; A61P35/00 ; A61P37/00
摘要：
The present invention relates to novel compounds selected from substituted oxazole derivatives of formula (I) that selectively modulate, regulate, and/or inhibit signal transduction mediated by certain native and/or mutant tyrosine kinases implicated in a variety of human and animal diseases such as cell proliferative, metabolic, allergic, and degenerative disorders. More particularly, these compounds are potent and selective c-kit, bcr-abl and Flt-3 inhibitors.
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